http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Carbon-Nanotube Addition on Thermal Stability of Ti-based Metallic Glass Composites
Hsu Chih-Feng,Lee Pee-Yew 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The preparation of metallic glass composite powders was accomplished by the mechanical alloying of a pure Ti, Cu, Ni, Sn and carbon nanotube (CNT) powder mixture after 8 h milling. In the ball-milled composites, the initial CNT particles were dissolved in the Ti-based alloy glassy matrix. The bulk metallic glass composite was successfully prepared by vacuum hot pressing the as-milled CNT/ metallic glass composite powders. A significant hardness increase with the CNT additions was observed for the consolidated composite compacts.
Hsu-Feng Lu,Yu-Heng Lai,Hsiu-Chen Huang,I-Jung Lee,Lie-Chwen Lin,Hui-Kang Liu,Hsiao-Hsuan Tien,Cheng Huang 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension,cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associatedwith a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus andnonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospectivepharmaceutical therapies that directly target NAFLD are available at present. A Traditional ChineseMedicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose levelor thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolicsyndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity,hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, andhyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adiposetissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treatedwith GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved byGBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Ourfindings provide evidence for the traditional use of GBHT as therapy for the management of metabolicsyndrome.
Kuo-Feng Hua,A-Ching Chao,Ting-Yu Lin,Wan-Tze Chen,Yu-Chieh Lee,Wan-Han Hsu,Sheau-Long Lee,Hsin-Min Wang,Ding-I. Yang,Tz-Chuen Ju 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4
Background: Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion oftrinucleotide CAG repeat in the Huntingtin (Htt) gene. The major pathogenic pathways underlying HDinvolve the impairment of cellular energy homeostasis and DNA damage in the brain. The protein kinaseataxia-telangiectasia mutated (ATM) is an important regulator of the DNA damage response. ATM isinvolved in the phosphorylation of AMP-activated protein kinase (AMPK), suggesting that AMPK plays acritical role in response to DNA damage. Herein, we demonstrated that expression of polyQ-expandedmutant Htt (mHtt) enhanced the phosphorylation of ATM. Ginsenoside is the main and most effectivecomponent of Panax ginseng. However, the protective effect of a ginsenoside (compound K, CK) in HDremains unclear and warrants further investigation. Methods: This study used the R6/2 transgenic mouse model of HD and performed behavioral tests,survival rate, histological analyses, and immunoblot assays. Results: The systematic administration of CK into R6/2 mice suppressed the activation of ATM/AMPK andreduced neuronal toxicity and mHTT aggregation. Most importantly, CK increased neuronal density andlifespan and improved motor dysfunction in R6/2 mice. Conversely, CK enhanced the expression of Bcl2protected striatal cells from the toxicity induced by the overactivation of mHtt and AMPK. Conclusions: Thus, the oral administration of CK reduced the disease progression and markedlyenhanced lifespan in the transgenic mouse model (R6/2) of HD.
Lu, Hsu-Feng,Lai, Yu-Heng,Huang, Hsiu-Chen,Lee, I-Jung,Lin, Lie-Chwen,Liu, Hui-Kang,Tien, Hsiao-Hsuan,Huang, Cheng The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome.
Po-Hsun Wang,Hsu-Feng Lee,Yi-Chiang Huang,Yi-Jiun Jung,Fang-Lin Gong,Wen-Yao Huang 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.4
In the decision on the pros and cons of the optical and electrical properties of organic solar cells, the morphology has proven to be very important. Easy to change the morphology via adding a small amount of additive, because proton dissociation constant is the main reason for their application. In this study, the use of poly(3-hexylthiophene) and [6,6]-phenyl C61-butyric acid methyl ester as the donor and acceptor materials, and were subsequently doped with different quantity of 4,4'-sulfonyldiphenol, 4,4'-dihydroxybiphenyl, biphenyl-4,4'-dithiol. When the proton dissociation constant is higher and lower respectively, the morphology reveals earthworms-like and fiber-like. For the reason that when the additive is biphenyl-4,4'-dithiol, it can improve the power conversion efficiency of about 27% and the incident photon-to-current conversion efficiency of about 12%.
Effects of substrate treatment on the electroluminescence performance of flexible OLEDs
Chin H.Chen,Shih Feng Hsu,Shiao Wen Hwang,Shih-Nan Lee 한국물리학회 2004 Current Applied Physics Vol.4 No.6
Electroluminescence (EL) performance of exible organic light-emitting device (FOLED) has been found to be highly dependentupon the morphology of the surface of the indium thin oxide (ITO)/plastic substrate as well as the patterning and processingconditions of the substrate. We will present evidence showing that luminance eciency of FOLED can be greatly improved bypretreatment. Surface analysis of the ITO/PET by means of atomic force microscope (AFM) and optical microscope will becompared with that of the ITO/glass and the inuence of exible OLEDs substrate treatment by various methods on EL perfor-mance will also be discussed.
Fabrication of blue top-emitting organic light-emitting devices with highly saturated color
Chin H.Chen,Chung-Chun Lee,Andrew T.Hu,Shih Feng Hsu 한국물리학회 2004 Current Applied Physics Vol.4 No.6
Blue top-emitting organic light-emitting devices (TOLEDs) with highly saturated color were developed by microcavity eect. Thedevice structure studied was glass/reective silver/indium-tin oxide (ITO)/organic electroluminescent stack/semi-transparent cathode(calcium/silver). By changing the thicknesses of ITO and organic layers in the microcavity structure device doped withp-bis(p-N,N-di-phenyl-aminostyryl)benzene (DSA-ph), highly saturated color with Commission Internationale de L’Eclairage chromaticitycoordinates (CIEx;y) of (0.14, 0.08) was obtained.
Ram Gopal,Yi-Chiang Huang,Hsu-Feng Lee,Ming-Sien Chang,Wen-Yao Huang 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.3
A new novel blue light emitting polymer containing carbazole andanthracene derivatives has been successfully synthesized via polycondensationchemical reaction of diol and difluoro monomers. An effort has been madeto raise the band gap of blue light emitter by lowering the conjugation extentin the backbone. The synthesized blue polymer exhibits decent solubility,good process ability, high thermal stability, high glass transition temperature(272 °C) and the decomposition temperature of 358 °C. The UV-visabsorption spectra and photoluminescence spectra depict that the lightemission lies in blue region. The solid state photoluminescence (PL) spectraof the polymer (λPL = 456 nm) shows red shift (Δλ = 37 nm) as comparedwith the corresponding solution PL spectra, presumably due to lowerintermolecular distance in solid state. The multi-layered polymer lightemitting diode was fabricated, using blue polymer with ITO/PEDOT: PSS/BP/LiF/Al architecture. The luminance-voltage (L-V) and current densityvoltage(J-V) curves show a maximum luminance of 7544 cd m−2, amaximum emission efficiency of 4.2 cd A−1, a maximum current density of453 mA cm−2 at a turn-on voltage of 4.5 V. Moreover, the PLED instigatepure blue EL emission, stable at 436 nm with outstanding CIE coordinates of(x = 0.15, y = 0.08), which is close to the pure NTSC blue coordinates of(0.14, 0.08).
Wen-Hsuan Tseng,Wei-Chung Hsu,Tsung-Lin Yang,Tzu-Yu Hsiao,Jia-Feng Wu,Hui-Chuan Lee,Hsiu-Po Wang,Ming-Shiang Wu,Ming-Shiang Wu,Ping-Huei Tseng 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.3
Background/AimsLaryngeal symptoms are largely treated with empiric proton pump inhibitor (PPI) therapy if no apparent pathology shown on ear, nose, and throat evaluation and reflux-related etiologies are suspected. However, treatment response remains unsatisfactory. This study aimed to investigate the clinical and physiological characteristics of patients with PPI-refractory laryngeal symptoms. MethodsPatients with persistent laryngeal symptoms despite PPI treatment for ≥ 8 weeks were recruited. A multidisciplinary evaluation comprising validated questionnaires for laryngeal symptoms (reflux symptom index [RSI]), gastroesophageal reflux disease symptoms, psychological comorbidity (5-item brief symptom rating scale [BSRS-5]) and sleep disturbance (Pittsburgh sleep quality index [PSQI]), esophagogastroduodenoscopy, ambulatory impedance-pH monitoring, and high-resolution impedance manometry were performed. Healthy asymptomatic individuals were also recruited for comparison of psychological morbidity and sleep disturbances. ResultsNinety-seven adult patients and 48 healthy volunteers were analyzed. The patients had markedly higher prevalence of psychological distress (52.6% vs 2.1%, P < 0.001) and sleep disturbance (82.5% vs 37.5%, P < 0.001) than the healthy volunteers. There were significant correlations between RSI and BSRS-5 scores, and between RSI and PSQI scores (r = 0.26, P = 0.010, and r = 0.29, P = 0.004, respectively). Fifty-eight patients had concurrent gastroesophageal reflux disease symptoms. They had more prominent sleep disturbances (89.7% vs 71.8%, P < 0.001) than those with laryngeal symptoms alone but similar reflux profiles and esophageal motility. ConclusionsPPI-refractory laryngeal symptoms are mostly associated with psychological comorbidities and sleep disturbances. Recognition of these psychosocial comorbidities may help optimize management in these patients.