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The Study of Criteria Weight for Taiwan National Quality Award by Fuzzy Hierarchical Analysis
Li, Shao-Chang,Fu, Hsin-Pin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.2
In this paper, fuzzy hierarchical analysis (FHA) is used to explore the process by which the criteria weights of the Taiwan National Quality Award (TNQA) are assigned by TNQA committee members. Each member is allowed to employ fuzzy scales in place of exact scales. Each pairwise comparison of criteria is made through a questionnaire from each TNQA committee member. The membership function of trapezoidal fuzzy numbers is introduced to specify TNQA committee members' intentions. After FHA, the reasonable range of each criterion weight of TNQA is determined. The current criteria weights of TNQA are properly verified.
Lin Chih-Hsin,Hsieh Yu-Shao,Sun Ying-Chieh,Huang Wun-Han,Chen Shu-Ling,Weng Zheng-Kui,Lin Te-Hsien,Wu Yih-Ru,Chang Kuo-Hsuan,Huang Hei-Jen,Lee Guan-Chiun,Hsieh-Li Hsiu Mei,Lee-Chen Guey-Jen 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine’s screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (TauRD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC50 of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 TauRD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 TauRD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 TauRD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.
Indentation deformation of mesoporous anodic aluminum oxide
Te-Hua Fang,Tong Hong Wang,Shao-Hui Kang,Cheng-Hsin Chuang 한국물리학회 2009 Current Applied Physics Vol.9 No.4
Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes. Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes.
Choi, Sang-Il,Xie, Shuifen,Shao, Minhua,Odell, Jonathan H.,Lu, Ning,Peng, Hsin-Chieh,Protsailo, Lesia,Guerrero, Sandra,Park, Jinho,Xia, Xiaohu,Wang, Jinguo,Kim, Moon J.,Xia, Younan American Chemical Society 2013 Nano letters Vol.13 No.7
<P>Nanoscale Pt–Ni bimetallic octahedra with controlled sizes have been actively explored in recent years owning to their outstanding activity for the oxygen reduction reaction (ORR). Here we report the synthesis of uniform 9 nm Pt–Ni octahedra with the use of oleylamine and oleic acid as surfactants and W(CO)<SUB>6</SUB> as a source of CO that can promote the formation of {111} facets in the presence of Ni. Through the introduction of benzyl ether as a solvent, the coverage of both surfactants on the surface of resultant Pt–Ni octahedra was significantly reduced while the octahedral shape was still attained. By further removing the surfactants through acetic acid treatment, we observed a specific activity 51-fold higher than that of the state-of-the-art Pt/C catalyst for the ORR at 0.93 V, together with a record high mass activity of 3.3 A mg<SUB>Pt</SUB><SUP>–1</SUP> at 0.9 V (the highest mass activity reported in the literature was 1.45 A mg<SUB>Pt</SUB><SUP>–1</SUP>). Our analysis suggests that this great enhancement of ORR activity could be attributed to the presence of a clean, well-preserved (111) surface for the Pt–Ni octahedra.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2013/nalefd.2013.13.issue-7/nl401881z/production/images/medium/nl-2013-01881z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl401881z'>ACS Electronic Supporting Info</A></P>
Dermal Lipogenesis Inhibits Adiponectin Production in Hs68 Fibroblasts
( Kai-chen Hu ),( Tsung-yan Tsai ),( Chu-wen Shao ),( Hsin-i Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Adiponectin is one of the most abundant adipokines from the subcutaneous fat, and regulates multiple activities through endocrine, paracrine, or autocrine mechanisms. However, its expression in adipogenic induced fibroblasts, and the potential role in photoaging has not been determined. Here, human dermal fibroblasts, Hs68, were presented as a cell model of dermal lipogenesis through stimulation of adipogenic differentiation medium (ADM). Similar to other studies in murine pre-adipocyte models (i.e., 3T3-L1), Hs68 fibroblasts showed a tendency to lipogenesis based on lipid accumulation, triglyceride formation, and the expressions of PPAR-γ, lipoprotein lipase (LPL), and FABP4 mRNA. As expected, ADM-treated fibroblasts displayed a reduction on adiponectin expression. Overall, these results suggest that dermal lipogenesis may inhibit the expression of adiponectin.
The Influence of PMMA Bone Cements on the Osteoblasts and Osteoclasts
( Kai-chen Hu ),( Tsung-yan Tsai ),( Chu-wen Shao ),( Hsin-i Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Due to aging, deficiency of vitamins and minerals, a prior accident or injury, the bones in our body become weak and fragile and so may cause serious defect of hard bone tissues. In orthopaedic surgery, Polymethylmethacrylate (PMMA) bone cements are used to refill and remodel bone defect. PMMA bone cements are formulated by mixing the powder (polymer, PMMA) and the liquid (monomer, methyl methacrylate). During the process, the dimethyl-p-toluidine in the liquid activates the benzoyl peroxide catalyst in the powder and this initiates the polymerization of the monomer, which then binds together PMMA granules. However, PMMA bone cements have displayed cytotoxicity to bone tissue in clinic. In present study, we used PMMA with different molecular weights (Mw:1,5000, 12,0000, 35,0000 and 99,6000 dalton) to prepare 4 types of bone cements for studying the effect of molecular weight of polymeric additives. Chemical eluates were extracted from PMMA bone cements and examined for their bioactive effects on 7F2 osteoblast-like cells and Raw 264.7 microphages. Results demonstrated that PMMA bone cements and eluates could inhibit the differentiation and mineralization behavior of 7F2 osteoblast-like cells after the cytotoxicity of PMMA bone cements and elutes were no longer evident. Moreover, bone cements prepared with high molecular weight PMMA (MW: 99,6000 dalton) had less suppressive effect on cell differentiation and mineralization in comparison with others. In Raw 264.7 microphages, PMMA bone cements and eluates can inhibit osteoclast formation but there was no significant difference among 4 types of bone cements. The aim of this research is to investigate the influence of PMMA bone cements on osteoblasts and osteoclasts and we hope these results can provide some useful information for the clinical application of PMMA bone cements.
Investigate the Mechanical and Biological Activities of PVA Membranes
( Chih-chang Yeh ),( Kai-chen Hu ),( Tsung-yan Tsai ),( Chu-wen Shao ),( Ruey-shyang Chen ),( Hsin-i Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Polyvinyl alcohol (PVA) is a water-soluble synthetic polymer and which has high tensile strength and flexibility, low toxicity and good biocompatibility for the application of soft tissue engineering. Generally, PVA can be crosslinked to form 3-D structure by a variety of methods, such as chemical crosslinking, irradiation or the freeze-thaw techniques. In contrast, chemical-crosslinked PVA structure has good elasticity, high water content, and stability at room temperature but most of crosslinking reagents such as glutaradehyde have high cytotoxicity. In here, we used low toxic genipin as crosslinking reagent for the formulation of PVA membrane. Thermal behavior and mechanical properties of genipin-crosslinked PVA membrane have been measured by thermo gravimetric analyzer and universal testing machine. Genipin-crosslinked PVA membrane had a smooth surface and the contact angel was about 67°. The swelling test displayed that genipin-crosslinked PVA membrane had high water content (130%) and the increase of PVA molecular weight can slightly improve water content. Moreover, dried genipin-crosslinked PVA membrane presented higher tensile strength (7.21MPa) but lower ductility (3.4%) than hydrated membrane (3.9MPa and 302.4%). Interestingly, rehydration of dried PVA membrane can maintain similar ductility to original hydrated membrane but the tensile strength was reduced by 40%. Therefore, drying process may break some hydrogen bonding between the polymer structure of PVA membrane. In MTT assay, there was some toxicity remained in genipin-PVA membrane but cell survivability was 1.5-1.9 fold higher than glutaradehyde-crosslinked PVA membrane. Overall, genipin-crosslinked PVA membrane showed low toxicity, good cell attachment and growth of human foreskin fibroblasts. After the cell culture study, the degradation of genipin-crosslinked PVA membrane was investigated by scanning electron microscope. Therefore, genipin-crosslinked PVA membrane is a biodegradable material and which can apply in soft tissue engineering due to its good elastic behavior.