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Jang, Hongje,Choi, Myung-Ho,Yim, Yeajee,Kim, Young-Kwan,Min, Dal-Hee Wiley-VCH 2015 Advanced Healthcare Materials Vol.4 No.12
<P>Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2 /NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO2 . Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.</P>
Jang, Hongje,Min, Dal-Hee American Chemical Society 2015 ACS NANO Vol.9 No.3
<P>The polyvinylpyrrolidone (PVP)-coated spherically clustered porous gold–silver alloy nanoparticle (PVP-SPAN) was prepared by low temperature mediated, partially inhibited galvanic replacement reaction followed by silver etching process. The prepared porous nanostructures exhibited excellent photothermal conversion efficiency under irradiation of near-infrared light (NIR) and allowed a high payload of both doxorubicin (Dox) and thiolated dye-labeled oligonucleotide, DNAzyme (FDz). Especially, PVP-SPAN provided 10 times higher loading capacity for oligonucleotide than conventional hollow nanoshells due to increased pore diameter and surface-to-volume ratio. We demonstrated highly efficient chemo-thermo-gene multitherapy based on codelivery of Dox and FDz with NIR-mediated photothermal therapeutic effect using a model system of hepatitis C virus infected human liver cells (Huh7 human hepatocarcinoma cell line containing hepatitis C virus NS3 gene replicon) compared to conventional hollow nanoshells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-3/nn506492s/production/images/medium/nn-2014-06492s_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn506492s'>ACS Electronic Supporting Info</A></P>
Jang, Hongje,Kim, Dong-Eun,Min, Dal-Hee American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.23
<P>Hollow Au-Ag bimetallic nanoshell possessing hydrophobic interior space and hydrophilic exterior surface was prepared and its application as a chemo-thermo-gene therapeutic agent based on its high payload of multiple drugs having different water solubility was demonstrated. The multifunctional drug delivery system is based on the hydrophobic interior created by the self-assembled monolayer (SAM) of hexanethiol onto the inner surface of the hollow metallic nanoshells whereas the outer surface was mostly coated by hydrophilic biocompatible polymer. The nanoshells having surface environment modified by hexanethiol SAMs provided high capacity both for hydrophilic DNAzyme (Dz) to induce gene silencing and for hydrophobic SN38 (7-ethyl-10-hydroxycamptothecin), anticancer drug. The release of the loaded Dz and SN38 was independently triggered by an acidic environment and by photothermal temperature elevation upon irradiation, respectively. The chemo-thermo-gene multitherapy based on the present nanoshells having modified surface environment showed high efficacy in quantitative cell-based assays using Huh7 human liver cell containing hepatitis C viral NS3 gene replicon RNA.</P>
Jang, Hongje,Kim, Young-Kwan,Huh, Hyun,Min, Dal-Hee American Chemical Society 2014 ACS NANO Vol.8 No.1
<P>Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au–Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au–Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation <I>via</I> Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au–Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-1/nn404833b/production/images/medium/nn-2013-04833b_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn404833b'>ACS Electronic Supporting Info</A></P>
Jang, Hongje,Kang, Kyungtae,El-Sayed, Mostafa A. The Royal Society of Chemistry 2017 Journal of Materials Chemistry B Vol.5 No.30
<P>To conquer cancer, one of the most dangerous and common diseases faced by humanity, many therapeutic approaches have been researched and developed. Discovery of highly effective therapeutic molecules without side effects and novel strategies for their effective delivery are areas receiving recent global interest. Here, we describe a facile one-pot synthetic method for making gold nanoparticles coated with fucoidan, a natural product extracted from brown seaweed and a promising anticancer biopolymer. This nanoparticle formulation with well-controlled size distribution shows promise in enhancing the therapeutic and delivery efficacy. Moreover, stable surface modification of fucoidan coating followed by conjugation of doxorubicin through cleavable linkage significantly improved the anticancer effect. Fucoidan-coated gold nanoparticles containing doxorubicin exhibited more greatly enhanced anticancer effect than any other related platform following fucoidan-based cancer treatment adopting the nanoparticle integrated system.</P>
Facile synthesis of robust and biocompatible gold nanoparticles
Jang, Hongje,Kim, Young-Kwan,Ryoo, Soo-Ryoon,Kim, Mi-Hee,Min, Dal-Hee Royal Society of Chemistry 2010 Chemical communications Vol.46 No.4
<P>Biocompatible and robust gold nanoparticles (AuNPs) were prepared <I>via</I> a simple synthetic strategy employing dextran as a reducing agent and surface coating material. Cross-linking and amination of the surface-coated dextran significantly improved the colloidal stability of AuNPs and rendered the nanoparticles more amenable to bioconjugation.</P> <P>Graphic Abstract</P><P>Gold nanoparticles (AuNPs) were prepared by employing dextran as a reducing agent and surface coating material. Colloidal stability, biocompatibility, and capability of bioconjugation will make the AuNPs readily applicable in biology. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b919971n'> </P>
A Graphene-Based Platform for the Assay of Duplex-DNA Unwinding by Helicase
Jang, Hongje,Kim, Young-Kwan,Kwon, Hyun-Mi,Yeo, Woon-Seok,Kim, Dong-Eun,Min, Dal-Hee WILEY-VCH Verlag 2010 Angewandte Chemie Vol.49 No.33
<B>Graphic Abstract</B> <P>Time to unwind: Graphene oxide (GO) enables the quantitative measurement of helicase-dependent double-stranded DNA (dsDNA) unwinding activity in real time. GO selectively binds to unwound fluorescent-dye-labeled single-stranded DNA and quenches its fluorescence (see picture). The helicase activity is monitored by following the change in fluorescence. <img src='wiley_img_2010/14337851-2010-49-33-ANIE201001332-content.gif' alt='wiley_img_2010/14337851-2010-49-33-ANIE201001332-content'> </P>
A Graphene-Based Platform for the Assay of Duplex-DNA Unwinding by Helicase
Jang, Hongje,Kim, Young-Kwan,Kwon, Hyun-Mi,Yeo, Woon-Seok,Kim, Dong-Eun,Min, Dal-Hee WILEY-VCH Verlag 2010 Angewandte Chemie Vol.122 No.33
<B>Graphic Abstract</B> <P>Mit bloßen Auge zu erkennen: Mithilfe von Graphenoxid (GO) kann die Helicase-abhängige Entwindung doppelsträngiger DNA (dsDNA) quantitativ und in Echtzeit verfolgt werden. GO bindet selektiv an entwundene fluoreszenzmarkierte einzelsträngige DNA und löscht die Fluoreszenz (siehe Bild). Die Helicaseaktivität wird über die Fluoreszenzänderung registriert. <img src='wiley_img_2010/00448249-2010-122-33-ANGE201001332-content.gif' alt='wiley_img_2010/00448249-2010-122-33-ANGE201001332-content'> </P>