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FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation
Cui, Yan-Hong,Kim, Hyeonmi,Lee, Minyoung,Yi, Joo Mi,Kim, Rae-Kwon,Uddin, Nizam,Yoo, Ki-Chun,Kang, Jae Hyeok,Choi, Mi-Young,Cha, Hyuk-Jin,Kwon, Ok-Seon,Bae, In-Hwa,Kim, Min-Jung,Kaushik, Neha,Lee, Su-J Nature Publishing Group 2018 Oncogene Vol. No.
Xue-Wei Cao,Hong-Mi Cui,Yuan Yao,Ai-Sheng Xiong,Xi-Lin Hou,Ying Li 한국식물학회 2017 Journal of Plant Biology Vol.60 No.4
Shoot branching (tillering) primarily determinesplant shoot architecture and has been studied in many plants. Shoot branching is an important trait in non-heading Chinesecabbage (Brassica rapa ssp. chinensis Makino). The B. rapassp. chinensis var. multiceps exhibits unique and multipleshoot branching characteristics. Here, we analyzed the variationin shoot branching between ‘Maertou,’ with multiple shootbranching, and ‘Suzhouqing,’ a common variety. The levelsof endogenous indole-3-acetic acid (IAA), zeatin ribosideand active gibberellins in the shoot meristem tissues of thetwo cultivars were quantified by enzyme-linked immunosorbentassay during the vegetative growth stage. High levels of IAAmaintained axillary bud dormancy and repressed axillary budoutgrowth allowing shoot branching to form in the vegetativestage in ‘Suzhouqing.’ In contrast, low levels of IAA did notinhibit axillary buds in ‘Maertou,’ while a high level of cytokininpromoted axillary bud growth and branch shoot development. Exogenous hormone (rac-GR24 and 6-benzylaminopurine)treatment showed that ‘Maertou’ was relatively sensitive tocytokinin, because the fold changes of cytokinin-responsivegenes in ‘Maertou’ were significantly more frequent than thosein ‘Suzhouqing’. Cytokinin was the direct regulator for axillarybud growth of ‘Maertou’. Compared with ‘Suzhouqing’,‘Maertou’ was sensitive to cytokinin and this weakened thestrigolactone–cytokinin branching pathway.
DNA detection using a light-emitting polymer single nanowire
Park, Dong Hyuk,Kim, Nari,Cui, Chunzhi,Hong, Young Ki,Kim, Mi Suk,Yang, Doo-Ho,Kim, Dae-Chul,Lee, Hyunsoo,Kim, Jeongyong,Ahn, Dong June,Joo, Jinsoo Royal Society of Chemistry 2011 Chemical communications Vol.47 No.28
<P>Functionalization of light-emitting poly(3-methylthiophene) (P3MT) nanowires (NWs) with probe-DNA (p-DNA) and their label-free recognition of target-DNA (t-DNA) were correlated quantitatively with both the photoluminescence (PL) color and intensity of P3MT NWs.</P> <P>Graphic Abstract</P><P>The label-free optical detection of DNA sequences is quantitatively correlated with both light emission color and intensity of P3MT single NWs. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc11362c'> </P>
Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells.
Kim, Rae-Kwon,Suh, Yongjoon,Cui, Yan-Hong,Hwang, Eunji,Lim, Eun-Jung,Yoo, Ki-Chun,Lee, Ga-Haeng,Yi, Joo-Mi,Kang, Seok-Gu,Lee, Su-Jae Japanese Cancer Association 2013 CANCER SCIENCE Vol.104 No.9
<P>Glioblastoma remains an incurable brain disease due to the prevalence of its recurrence. Considerable evidence suggests that glioma stem-like cells are responsible for glioma relapse after treatment, which commonly involves ionizing radiation. Here, we found that fractionated ionizing radiation (2 Gy/day for 3 days) induced glioma stem-like cell expansion and resistance to anticancer treatment such as cisplatin (50 μM) or taxol (500 nM), or by ionizing radiation (10 Gy) in both glioma cell lines (U87, U373) and patient-derived glioma cells. Of note, concomitant increase of nitric oxide production occurred with the radiation-induced increase of the glioma stem-like cell population through upregulation of inducible nitric oxide synthase (iNOS). In line with this observation, downregulation of iNOS effectively reduced the glioma stem-like cell population and decreased resistance to anticancer treatment. Collectively, our results suggest that targeting iNOS in combination with ionizing radiation might increase the efficacy of radiotherapy for glioma treatment.</P>
5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATcl expression
( Ju Hee Kang ),( Zheng Ting ),( Mi Ran Moon ),( Jung Seon Sim ),( Jung Min Lee ),( Kyung Eun Doh ),( Sunhye Hong ),( Minghua Cui ),( Sun Choi ),( Hyeun Wook Chang ),( Hea Young Park Choo ),( Mijung Y 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
5-Lipoxygenase synthesizes leukotrienes from arachidonic acid. We developed three novel 5-LO inhibi-tors having a benzoxazole scaffold as a potential anti-osteoclastogenics. They significantly suppressed RANKL-induced osteoclast formation in mouse bone marrow-derived macrophages. Furthermore, one compound. K7, inhibited the bone resorptive activity of osteoclasts. The anti-osteoclastogenic effect of K7 was mainly attributable to reduction in the expression of NFATc1. an essential transcription factor for osteoclast differentiation. K7 inhibited osteoclast formation via ERK and p38 MAPK. as well as NF-KB signaling pathways. K7 reduced lipopolysaccharide (LPS)-induced osteoclast formation in vivo. corroborating the in vitro data. Thus, IG exerted an inhibitory effect on osteoclast formation in vitro and in vivo, properties that make it a potential candidate for the treatment of bone diseases associated with excessive bone resorption.
Shin, Soon Shik,Park, Dongmin,Lee, Hee Young,Hong, Yeonhee,Choi, Jeonghyun,Oh, Jaeho,Lee, Hyunghee,Lee, Hye Rim,Kim, Mi Ryeo,Shen, Zhi Bin,Cui, Hong Hua,Yoon, Michung Informa Healthcare 2012 Pharmaceutical biology Vol.50 No.4
<P><I>Context</I>: Since AMP-activated protein kinase (AMPK) activation in skeletal muscle of obese rodents stimulates fatty acid oxidation, it is reasonable to hypothesize that pharmacological activation of AMPK might be of therapeutic benefit in obesity.</P><P><I>Objective</I>: To investigate the effects of the traditional Korean anti-obesity drug GGEx18, a mixture of three herbs, <I>Laminaria japonica</I> Aresch (Laminariaceae), <I>Rheum palmatum</I> L. (Polygonaceae), and <I>Ephedra sinica</I> Stapf (Ephedraceae), on obesity and the involvement of AMPK in this process.</P><P><I>Materials and methods</I>: After high fat diet-induced obese mice were treated with GGEx18, we studied the effects of GGEx18 on body weight, fat mass, skeletal muscle lipid accumulation, and the expressions of AMPK, peroxisome proliferator-activated receptor &aacgr;郭 (PPARα), and PPARα target genes. The effects of GGEx18 and/or the AMPK inhibitor compound C on lipid accumulation and expression of the above genes were measured in C2C12 skeletal muscle cells.</P><P><I>Results:</I> Administration of GGEx18 to obese mice for 9 weeks significantly (<I>p</I> < 0.05) decreased body and adipose tissue weights compared with obese control mice (<I>p</I> < 0.05). Lipid accumulation in skeletal muscle was inhibited by GGEx18. GGEx18 significantly (<I>p</I> < 0.05) increased skeletal muscle mRNA levels of AMPKα1 and AMPKα2 as well as PPARα and its target genes. Consistent with the <I>in vivo</I> data, GGEx18 inhibited lipid accumulation, and similar activation of genes was observed in GGEx18-treated C2C12 cells. However, compound C inhibited these effects in C2C12 cells.</P><P><I>Discussion and conclusion:</I> These results suggest that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation.</P>
경신강지환(輕身降脂丸)18의 분자생물학적인 비만조절 기전에 관한 연구
이희영 ( Hee Young Lee ),윤기현 ( Ki Hyeon Yoon ),서부일 ( Bu Il Seo ),박규열 ( Gyu Ryeol Park ),윤미정 ( Mi Chung Yoon ),심지빈 ( Zhi Bin Shen ),최홍화 ( Hong Hua Cui 崔紅花 ),신순식 ( Soon Shik Shin ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.1
Objectives: This study was undertaken to verify the modulation mechanism of Gyeongshingangjeehwan18 (GGEx18) in ob/ob male mice. Methods: Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups: obese control, GGEx15 (Ephedra sinica Stapf + Rheum palmatum L.), GGEx16 (Ephedra sinica Stapf + Laminaria japonica Aresch), GGEx17 ( Rheum palmatum L. + Laminaria japonica Aresch), and GGEx18 ( Ephedra sinica Stapf + Laminaria japonica Aresch + Rheum palmatum L.). After mice were treated with several kinds of GGEx for 11 weeks, the mRNA expression of peroxisome proliferator-activated receptor (PPAR) target genes and uncoupling protein (UCP) were measured. In addition, PPARα and PPARβ transactivation was examined in NMu2Li hepatocytes, C2C12 myocytes, and 3T3-L1 preadipocytes using transient transfection assays. Results: 1. Hepatic PPARα target genes, such as ACOX and VLCAD mRNA levels were significantly increased by GGEx18 compared with obese controls. In skeletal muscle, LCAD mRNA expression was stimulated by GGEx16, GGEx17, and GGEx18, whereas MCAD mRNA expression by GGEx17 and GGEx18. PPARβ target LPL mRNA levels were also increased by GGEx16, GGEx17, and GGEx18 in skeletal muscle, but adipose LPL mRNA levels were decreased. In addition, GGEx18 upregulated UCP mRNA expression in skeletal muslce. 2. PPARα reporter gene expression was increased by GGEx18 in NMu2Li cells compared with vehicle. PPARα and PPARβ reporter activities were also increased by all GGEx treatments in C2C12 and 3T3-L1 cells. Conclusions: These results suggest that GGEx can act as PPARα and PPARβ activators, and that GGEx may regulate obesity by stimulating PPARα, PPARβ, and UCP activity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.
GGEx18의 ethyl acetate 분획물에 의한 고지방식이 비만 마우스의 식이효율과 혈중 leptin 농도에 미치는 영향
박기정,이희영,이혜림,윤미정,박선동,이용태,심지빈,최홍화,신순식,Park, Ki-Jeong,Lee, Hee-Young,Lee, Hye-Rim,Yoon, Mi-Chung,Park, Sun-Dong,Lee, Yong-Tae,Shen, Zhi-Bin,Cui, Hong-Hua,Shin, Soon-Shik 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1
Objectives : This study was designed to determine the effects of the GGEx18 ethyl acetate fraction(EF) on body weight gain, feeding efficiency ratio, and obesity-related factors in plasma as well as histology of liver and adipose tissues using high fat diet-fed male C57BL/6N obese mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, EF(1), EF(2) and EF(3). After mice were treated with EF for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also analysed histology of liver and adipose tissues on high fat diet-fed male C57BL/6N obese mice. Results : Compared with control, EF-treated mice had significantly lower body weight gain and feeding efficiency ratio. Consistent with the effects on body weight gain, EF significantly decreased the adipose tissue weight compared with control. Consistent with the effects on feeding efficiency ratio, EF significantly decreased plasma leptin concentrations compared with control. EF reduced the size of adipocytes as well as hepatic lipid accumulation compared with control. EF seems to be safe since not only the plasma levels of ALT and AST are within the normal range, but also EF did not show any toxic effects on organs. EF(3) was most effective among EF(1), EF(2), and EF(3) at doses of 25, 50, and 100 mg/kg, respectively. Conclusions : These results demonstrate that EF effectively reduces body weight gain, feeding efficiency ratio in high fat diet-fed obese mice, leading to the modulation of obesity. In addition, EF decreases the size of adipocytes and improves plasma lipids and controls hepatic lipid accumulation, suggesting that EF may act as a therapeutic agent for obesity.