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Yang, Zhen-Hai,Zhou, Chun-Lin,Zhu, Hong,Li, Jiu-Hong,He, Chun-Di Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism. Methods: In this study, SNP309 was verified to be associated with overexpression of MDM2 in tumor cells. Bioinformatics predicts that the T to G substitution at SNP309 generates a stronger E2F1 binding site, which was confirmed by ChIP and luciferase assays. Results: E2F1 knockdown downregulates the expression of MDM2, which confirms that E2F1 is a functional upstream regulator. Furthermore, tumor cells with the GG genotype exhibited a higher proliferation rate than TT, correlating with cyclin D1 expression. E2F1 depletion significantly inhibits the proliferation capacity and downregulates cyclin D1 expression, especially in GG genotype skin fibroblasts. Notably, E2F1 siRNA effects could be rescued by cyclin D1 overexpression. Conclusion: Taken together, a novel modulator E2F1 was identified as regulating MDM2 expression dependent on SNP309 and further mediates cyclin D1 expression and tumor cell proliferation. E2F1 might act as an important factor for SNP309 serving as a rate-limiting event in carcinogenesis.
Ren, Hong-Xuan,Chen, Xing,Huang, Xing-Jiu,Im, Maesoon,Kim, Dong-Haan,Lee, Joo-Hyung,Yoon, Jun-Bo,Gu, Ning,Liu, Jin-Huai,Choi, Yang-Kyu Royal Society of Chemistry 2009 Lab on a chip Vol.9 No.15
<P>We use a conventional and straightforward route to fabricate scalable morphology-controlled regular structures. This route is based on the etching of PDMS microlens array in CF<SUB>4</SUB> and CF<SUB>4</SUB>/O<SUB>2</SUB> plasma. PDMS microlens array can be changed to regularly isolated microdot structures array in CF<SUB>4</SUB> plasma. Microbowl shaped structures array can be reached in CF<SUB>4</SUB>/O<SUB>2</SUB> plasma. Moreover, a set of structures after CF<SUB>4</SUB> plasma treatment display superhydrophobicity, while a set of structures after CF<SUB>4</SUB>/O<SUB>2</SUB> plasma treatment present hydrophilicity. DNA molecules can be readily enriched on the hydrophilic surface. We believe that the regular structure array surfaces provide a useful inspiration towards biomolecular detection and transportation in biochips.</P> <P>Graphic Abstract</P><P>Morphology-controlled regular structures and their opposite wettabilities can be obtained based on the etching of PDMS microlens array in CF<SUB>4</SUB> and CF<SUB>4</SUB>/O<SUB>2</SUB> plasma. DNA molecules enrichment is also investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b905804d'> </P>
Jing Chen,Ji-Qing Qiu,Peng Shi,Hong-Jiu Yang 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
In this paper, the problem of stochastic robust stability of time-varying delay neutral system with Markovian jump parameters is investigated. The jumping parameters are considered as a continuous-time, continuous state Markov process. Based on the Lyapunov-Krasovskii functional approach, a new delay-dependent stochastic stability criteria is presented in terms of LMIs. A numerical example is given to illustrate the effectiveness of the developed method.