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Antiproliferative effects of zinc-citrate compound on hormone refractory prostate cancer.
Hong, Sung Hoo,Choi, Yong Sun,Cho, Hyuk Jin,Lee, Ji Youl,Kim, Joon Chul,Hwang, Tae Kon,Kim, Sae Woong China National Publications ImportExport Corp., Ex 2012 Chinese Journal of Cancer Research Vol.24 No.2
<P>To investigate the antiproliferative effects of zinc-citrate compound on hormone refractory prostate cancer (HRPC).</P>
A hybridized graphene carrier highway for enhanced thermoelectric power generation
Hong, Seunghyun,Kim, Eun Sung,Kim, Wonyoung,Jeon, Seong-Jae,Lim, Seong Chu,Kim, Ki Hong,Lee, Hoo-Jeong,Hyun, Seungmin,Kim, Duckjong,Choi, Jae-Young,Lee, Young Hee,Baik, Seunghyun The Royal Society of Chemistry 2012 Physical Chemistry Chemical Physics Vol.14 No.39
<P>The decoupling and enhancement of both Seebeck coefficient and electrical conductivity were achieved by constructing the <I>c</I>-axis preferentially oriented nanoscale Sb<SUB>2</SUB>Te<SUB>3</SUB> film on monolayer graphene. The external graphene layer provided a highway for charge carriers, which were stored in the thicker binary telluride film, due to the extremely high mobility.</P> <P>Graphic Abstract</P><P>The enhancement of both Seebeck coefficient and electrical conductivity was achieved by the <I>c</I>-axis preferentially oriented Sb<SUB>2</SUB>Te<SUB>3</SUB> film on graphene. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp42936e'> </P>
Hong, Sung Pyo,Park, Hoo Keun,Oh, Ji Hye,Yang, Heesun,Do, Young Rag The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.36
<P>Cubic AgIn<SUB>5</SUB>S<SUB>8</SUB> (c-AgIn<SUB>5</SUB>S<SUB>8</SUB>) as well as orthorhombic AgInS<SUB>2</SUB> (o-AgInS<SUB>2</SUB>) and tetragonal AgInS<SUB>2</SUB> (t-AgInS<SUB>2</SUB>) nanocrystal (NC) luminophores are successfully prepared by adjusting the stoichiometric [Ag] : [In] ratio at reaction temperatures ranging from 100 to 180 °C. The photoluminescence (PL) quantum yield (QY) of c-AgIn<SUB>5</SUB>S<SUB>8</SUB> NCs reached 18.8%, which is much higher than that of o-AgInS<SUB>2</SUB> and t-AgInS<SUB>2</SUB>. In this study, the identification and characterization of efficient c-AgIn<SUB>5</SUB>S<SUB>8</SUB> luminophore NCs are reported for the first time. Broad PL bands, large Stokes shifts and long PL lifetimes indicate that the PL of c-AgIn<SUB>5</SUB>S<SUB>8</SUB> as well as o-AgInS<SUB>2</SUB> and t-AgInS<SUB>2</SUB> NCs can be attributed to donor–acceptor (D–A) pair recombinations. The PL peak shifts and changes in the PL intensity depending on the excitation intensity and temperature confirm that the c-AgIn<SUB>5</SUB>S<SUB>8</SUB> NCs comply with D–A pair recombinations. The PL emission of the NCs can be enhanced <I>via</I> a solid-solution with ZnS and the PL wavelength can be tuned by varying the stoichiometric [Ag] : [In] ratio and the preparation temperature. The best c-AgIn<SUB>5</SUB>S<SUB>8</SUB>–ZnS sample presents a PL emission in the range of 552–587 nm with a maximum QY of 61.3%. The luminous efficacy and color rendering index (CRI) of these AgIn<SUB>5</SUB>S<SUB>8</SUB>–ZnS NC-based white light-emitting diodes (LEDs) were respectively 53 lm W<SUP>−1</SUP> and 74 at 3700 K under 60 mA. The development of an efficient AgIn<SUB>5</SUB>S<SUB>8</SUB>–ZnS NC to be applied as a color-converting material in white LEDs as demonstrated in this work provides the possibility of various potential applications in the fields of optic, optoelectronic and bio-related devices.</P> <P>Graphic Abstract</P><P>Cubic AgIn<SUB>5</SUB>S<SUB>8</SUB> as well as orthorhombic and tetragonal AgInS<SUB>2</SUB> nanocrystal luminophores and their ZnS-alloyed nanocrystals are prepared and characterized by studying their structural and optical properties and applicability to white LEDs. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm33879c'> </P>
FX: an RNA-Seq analysis tool on the cloud.
Hong, Dongwan,Rhie, Arang,Park, Sung-Soo,Lee, Jongkeun,Ju, Young Seok,Kim, Sujung,Yu, Saet-Byeol,Bleazard, Thomas,Park, Hyun-Seok,Rhee, Hwanseok,Chong, Hyonyong,Yang, Kap-Seok,Lee, Yeon-Su,Kim, In-Hoo Oxford University Press 2012 Bioinformatics Vol.28 No.5
<P>FX is an RNA-Seq analysis tool, which runs in parallel on cloud computing infrastructure, for the estimation of gene expression levels and genomic variant calling. In the mapping of short RNA-Seq reads, FX uses a transcriptome-based reference primarily, generated from ~160 000 mRNA sequences from RefSeq, UCSC and Ensembl databases. This approach reduces the misalignment of reads originating from splicing junctions. Unmapped reads not aligned on known transcripts are then mapped on the human genome reference. FX allows analysis of RNA-Seq data on cloud computing infrastructures, supporting access through a user-friendly web interface.</P>
Induction of Apoptosis of Bladder Cancer Cells by Zinc-Citrate Compound
Hong, Sung-Hoo,Choi, Yong Sun,Cho, Hyuk Jin,Lee, Ji Youl,Hwang, Tae-Kon,Kim, Sae Woong 대한비뇨기과학회 2012 Investigative and Clinical Urology Vol.53 No.11
<P><B>Purpose</B></P><P>Zinc is one of the trace minerals in the body and is known to have an anticancer effect by inducing apoptosis in prostate cancer. We aimed to investigate the antiproliferative effects of a zinc-citrate compound in bladder cancer.</P><P><B>Materials and Methods</B></P><P>A bladder cancer cell line (MBT-2) was treated with a zinc-citrate compound at different time intervals and concentrations. Mitochondrial (m)-aconitase activity was determined by use of the aconitase assay. DNA laddering analysis was performed to investigate apoptosis of MBT-2 cells. The molecular mechanism of apoptosis was investigated by Western blot analysis of p53, p21<SUP>waf1</SUP>, Bcl-2, Bcl-xL, and Bax and also by caspase-3 activity analysis.</P><P><B>Results</B></P><P>Treatment with the zinc-citrate compound resulted in a time- and dose-dependent decrease in cell number of MBT-2 cells. M-aconitase activity was significantly decreased. DNA laddering analysis indicated apoptosis of MBT-2 cells. The zinc-citrate compound increased the expression of p21<SUP>waf1</SUP> and p53 and reduced the expression of Bcl-2 and Bcl-xL proteins but induced expression of Bax protein. The zinc-citrate compound induced apoptosis of MBT-2 cells by activation of the caspase-3 pathway.</P><P><B>Conclusions</B></P><P>We have shown that a zinc-citrate compound induces apoptotic cell death in a bladder cancer cell line, MBT-2, by caspase-3 activation through up-regulation of apoptotic proteins and down-regulation of antiapoptotic proteins.</P>