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Hong, JinWoo,Yun, Chae-Ok Elsevier 2019 Molecular and cellular endocrinology Vol.487 No.-
<P><B>Abstract</B></P> <P>Relaxin (RLX) is an insulin-like polypeptide hormone that was initially introduced for its pregnancy-related function. Subsequent studies revealed that RLX possesses anti-fibrotic functions in tumors and nonreproductive tissues, such as skin, lungs, and others. This aspect of the RLX has been explored for the treatment of various illnesses, such as cardiac fibrosis, liver fibrosis, and solid tumors. With gene therapy coming into age with increasing number of products being approved by regulatory bodies in Europe and United States, we aim to discuss how RLX have been utilized in scope of gene therapy for treatment of various illnesses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Relaxin is a promising antifibrotic, pleiotropic, and cardioregulatory hormone. </LI> <LI> Recent phase III trial of recombinant relaxin has been disappointing. </LI> <LI> Relaxin gene therapy overcomes major hurdles of recombinant protein therapy. </LI> <LI> Relaxin gene therapy can be promising treatment for various illnesses. </LI> </UL> </P>
Chang, Jinwoo,Lee, Jin Bok,Kim, Jin Seog,Lee, Jin-Hong,Hong, Kiryong The Korean Society of Analytical Sciences 2022 분석과학 Vol.35 No.5
Deuterium (D) is an isotope with one more neutron number than hydrogen (H). Heavy elements rarely change their chemical properties with little effect even if the number of neutrons increases, but low-mass elements change their vibration energy, diffusion rate, and reaction rate because the effect cannot be ignored, which is called an isotope effect. Recently, in the semiconductor and display industries, there is a trend to replace hydrogen gas (H<sub>2</sub>) with deuterium gas (D<sub>2</sub>) in order to improve process stability and product quality by using the isotope effect. In addition, as the demand for D<sub>2</sub> in industries increases, domestic gas producers are making efforts to produce and supply D<sub>2</sub> on their own. In the case of high purity D<sub>2</sub>, most of them are produced by electrolysis of heavy water (D<sub>2</sub>O), and among D<sub>2</sub>, hydrogen deuteride (HD) molecules are present as isotope impurities. Therefore, in order to maximize the isotope effect of hydrogen in the electronic industry, HD, which is an isotope impurity of D<sub>2</sub> used in the process, should be small amount. To this end, purity analysis of D<sub>2</sub> for industrial processing is essential. In this study, HD quantitative analysis of D<sub>2</sub> for high purity D<sub>2</sub> purity analysis was established and hydrogen isotope RM (Reference material) was developed. Since hydrogen isotopes are difficult to analyze with general gas analysis instrument, they were analyzed using a high-precision mass spectrometer (Gas/MS, Finnigan MAT271). High purity HD gas was injected into Gas/MS, sensitivity was determined by a signal according to pressure, and HD concentrations in two bottles of D<sub>2</sub> were quantified using the corresponding sensitivity. The amount fraction of HD in each D<sub>2</sub> was (4518 ± 275) μmol/mol, (2282 ± 144) μmol/mol. D<sub>2</sub>, which quantifies HD amount using the developed quantitative analysis method, will be manufactured with hydrogen isotope RM and distributed for quality management and maintenance of electronic industries and gas producers in the future.
응급실에 방문한 호흡기증상을 가진 노인환자의 특성에 대한 연구
홍진우 ( Jinwoo Hong ),이휘재 ( Hui Jai Lee ),신종환 ( Jongwhan Shin ),유경민 ( Kyoung Min You ) 대한응급의학회 2024 대한응급의학회지 Vol.35 No.2
Objective: With the increase in the elderly population worldwide, there has been a corresponding increase in the proportion of elderly patients who visit the emergency department (ED). Therefore, research on the elderly not only aids in the treatment of diseases but also assists in the efficient utilization of limited medical resources. Respiratory symptoms are one of the most common and sometimes life-threatening symptoms in elderly patients. Knowing the factors that can predict the prognosis in advance can help with rapid diagnosis and immediate treatment. Methods: A retrospective study was conducted from September 2019 to March 2020 at an ED in an urban area. Patients with respiratory symptoms who were treated in the critical care area of the ED were reviewed. The ED clinical data were compared with the outcomes in the ED. Results: A total of 750 patients were screened, of which 703 were elderly patients. Many clinical factors showed variations between the elderly and non-elderly patients. Oxygen volume, elevated lactate level, elevated troponin level, hypocalcemia, and hypothermia were related with ED death or ICU admission among the elderly. Conclusion: We identified several clinical factors with respect to elderly ED patients with respiratory symptoms that were related to the clinical outcomes and can be used for decision-making and prediction of poor outcomes.
Single enzyme nanoparticles armored by a thin silicate network: Single enzyme caged nanoparticles
Hong, Sung-Gil,Kim, Byoung Chan,Na, Hyon Bin,Lee, Jinwoo,Youn, Jongkyu,Chung, Seung-Wook,Lee, Chang-Won,Lee, Byoungsoo,Kim, Han Sol,Hsiao, Erik,Kim, Seong H.,Kim, Byung-Gee,Park, Hyun Gyu,Chang, Ho Na Elsevier 2017 Chemical engineering journal Vol.322 No.-
<P><B>Abstract</B></P> <P>For the encapsulation of biomolecules in inorganic materials, we have developed a unique enzyme-silicate conjugate material that consists of a self-assembled molecularly thin silicate layer on the surface of each individual enzyme molecule. The enzyme-silicate conjugate materials, called single enzyme caged nanoparticles (SECNs), were synthesized via the silica polymerization on the surface of enzyme molecule after solubilizing each enzyme molecule in hexane by using a tiny amount of surfactant, called “ion-pairing”. SECNs possess near native enzyme activity in aqueous media with minimal substrate diffusional limitations, and are highly stable under the protection of silicate network cage. Due to their nearly molecular size, SECNs can also be adsorbed into mesoporous silica materials to yield robust and easily-recyclable enzymatic systems that can be used in a number of potential biocatalytic applications such as diagnostics, biosensors, biotransformations, biofuel production, bioremediation and CO<SUB>2</SUB> capture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Protocol of single enzyme caged nanoparticles (SECNs) has been developed. </LI> <LI> SECNs have ultra-thin silicate network on the surface of individual enzyme molecule. </LI> <LI> SECNs minimize substrate diffusional limitation, and inhibit the enzyme denaturation. </LI> <LI> SECNs can be immobilized into mesoporous silica for recyclable enzymatic systems. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>