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PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration
Kang, Hojin,Jo, Areum,Kim, Hyein,Khang, Rin,Lee, Ji-Yeong,Kim, Hanna,Park, Chi-Hu,Choi, Jeong-Yun,Lee, Yunjong,Shin, Joo-Ho Academic Press 2018 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice. In this study, we revealed that PARIS overexpression reprogrammed glucose metabolic pathway, leading to the increment of glycolytic proteins along with TKT reduction in the SN of AAV-PARIS injected mice. Knock-down of TKT in differentiated SH-SY5Y cells led to an increase of glycolytic enzymes and decrease of PPP-related enzymes whereas overexpression of TKT restored PARIS-mediated glucose metabolic shift, suggesting that glucose metabolic alteration by PARIS is TKT-dependent. Inhibition of PPP by either PARIS overexpression or TKT knock-down elevated the level of H<SUB>2</SUB>O<SUB>2</SUB>, and diminished NADPH and GSH levels, ultimately triggering the induction of HIF-1α, a master activator of glycolysis. In addition, TKT inhibition by stereotaxic injection of oxythiamine demonstrated slight decrement of dopaminergic neurons (DNs) in SN but not cortical neurons in the cortex, suggesting that TKT might be a survival factor of DNs. In differentiated SH-SY5Y, cell toxicity by GFP-PARIS was partially restored by introduction of Flag-TKT and siRNA-HIF-1α. We also observed the increase of HIF-1α and glycolytic hexokinase 2 in the SN of Parkinson's disease patients. Taken together, these results suggest that PARIS accumulation might distort the balance of glucose metabolism, providing clues for understanding mechanism underlying selective DNs death by PARIS.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PARIS reprograms glucose metabolism via TKT suppression. </LI> <LI> Increased oxidative stress by TKT reduction induces HIF-1α. </LI> <LI> TKT overexpression and HIF-1α knock-down partially rescues PARIS toxicity. </LI> </UL> </P>
Kang, Hojin,Hong, Sung Ju,Park, Min,Jang, Hyun-Seok,Nam, Kiin,Choi, Soobong,Kim, Byung Hoon,Park, Yung Woo IOP 2019 Nanotechnology Vol.30 No.6
<P>We report on an electronic structure change of single-walled carbon nanotube (SWNT) on hexagonal boron nitride due to electron doping via high-pressure H<SUB>2</SUB> exposure. The fractional coverage of hydrogenated carbon atom is estimated to be at least <I>θ</I>?=?0.163 from the <I>in situ I</I> <SUB>ds</SUB>–<I>V</I> <SUB>g</SUB> measurements of the release process. Raman spectroscopy and x-ray photoelectron spectroscopy were carried out to support the <I>in situ</I> electrical measurements. In particular, we used the dissociative Langmuir-type model to yield the desorption coefficient <I>k</I> <SUB>des</SUB> by fitting it to the <I>in situ</I> electrical data. Finally, we applied this hydrogenation method to the SWNT network on the commercial Si/SiO<SUB>2</SUB> substrate to open the possibility of the scalable <I>n</I>-type semiconducting SWNT FETs.</P>
Hojin Kang,Yongjae Kim,Junhyun Kim,Heeyeop Chae 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
High selective etching process precision control is required in semiconductor devices. Perfluorocarbon compounds have intrinsic global warming issue. In this work, reactive ion etching process was conducted for SiO<sub>2</sub> and a-C in a dual frequency superimposed capacitively coupled plasmas (DFS-CCPs) reactor with C<sub>4</sub>H<sub>3</sub>F<sub>7</sub>O ether and alcohol plasmas. The etch rate and radical density showed that ether was higher than alcohol. Selectivity was superior when the low frequency power ratio was higher than high frequency power ratio.
Estimation of optimal margin for intrafraction movements during frameless brain radiosurgery.
Kang, Ki Mun,Chai, Gyu Young,Jeong, Bae Kwon,Ha, In-Bong,Lee, Sangbong,Park, Kyung Bum,Jung, Jin-Myung,Lim, Young Kyung,Yoo, Seung Hoon,Jeong, Hojin The American Association of Physicists in Medicine 2013 Medical physics Vol.40 No.5
<P>To examine the dosimetric effect of intrafraction movements occurred during image-guided frameless brain radiosurgery and to derive the optimal margin recipe to compensate the movement.</P>
Kang, Ki Mun,Jeong, Bae Kwon,Choi, Hoon‐,Sik,Yoo, Seung Hoon,Hwang, Ui‐,Jung,Lim, Young Kyung,Jeong, Hojin unknown 2015 Journal of applied clinical medical physics Vol.16 No.5
<P>We have investigated the combined effect of tissue heterogeneity and its variation associated with geometric error in stereotactic body radiotherapy (SBRT) for lung cancer. The treatment plans for eight lung cancer patients were calculated using effective path length (EPL) correction and Monte Carlo (MC) algorithms, with both having the same beam configuration for each patient. These two kinds of plans for individual patients were then subsequently recalculated with adding systematic and random geometric errors. In the ordinary treatment plans calculated with no geometric offset, the EPL calculations, compared with the MC calculations, largely overestimated the doses to PTV by ∼21%, whereas the overestimation were markedly lower in GTV by ∼12% due to relatively higher density of GTV than of PTV. When recalculating the plans for individual patients with assigning the systematic and random geometric errors, no significant changes in the relative dose distribution, except for overall shift, were observed in the EPL calculations, whereas largely altered in the MC calculations with a consistent increase in dose to GTV. Considering the better accuracy of MC than EPL algorithms, the present results demonstrated the strong coupling of tissue heterogeneity and geometric error, thereby emphasizing the essential need for simultaneous correction for tissue heterogeneity and geometric targeting error in SBRT of lung cancer.</P><P>PACS numbers: 87.55.D, 87.55.kh, 87.53.Ly, 87.55.‐x</P>