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RISS 인기검색어
- 검색키워드
- 저자 : Hoi-Sing Kwok (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor
Sung, Wai-Nam,Kwok, Hoi-Hin,Rhee, Man-Hee,Yue, Patrick Ying-Kit,Wong, Ricky Ngok-Shun The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4
Background: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE). Methods and Results: Combining in vitro and in vivo data, KGE at $500{\mu}g/mL$ was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR. Conclusion: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.
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Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor
Wai-Nam Sung,Hoi-Hin Kwok,Man-Hee Rhee,Patrick Ying-Kit Yue,Ricky Ngok-Shun Wong 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4
Background: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA(miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE). Methods and Results: Combining in vitro and in vivo data, KGE at 500 mg/mL was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR. Conclusion: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.
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Stereoscopic three-dimensional display with a fast-response liquid crystal polarization rotator
이정영,Man-Chun Tseng,Hoi-Sing Kwok 한국정보디스플레이학회 2013 Journal of information display Vol.14 No.3
A stereoscopic three-dimensional (3D) system using a polarization rotator is proposed. The polarization rotator converts the polarizations of images from different eyes in temporal multiplexing. A novel fast nematic liquid crystal mode is also proposed. The new liquid crystal mode has a fast response time and a high contrast, and is thus a good candidate as a polarization rotator. The proposed 3D system uses only passive polarized glasses, which are more convenient, lightweight, and low-cost than what? In addition, the polarization rotator can be applied to current two-dimensional displays and can become 3D-capable displays.
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