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Endocrine Disrupting Activities of Parabens: An Overview of Current Databases on Their Estrogenicity
Vu Hoang Dang,정의배 사단법인 한국동물생명공학회 2008 한국동물생명공학회지 Vol.23 No.4
Recently, parabens have been believed to act as xenoestrogens, an identified class of endocrine disruptors (EDs). These environmental compounds are the most well-known as preservatives in many commercial products, including food, cosmetics and pharmaceutical industries. It has been demonstrated that the human health risks of parabens result from a long-term exposure to skin in which this chemical group is rapidly absorbed through the skin. On the other hand, parabens are also completely absorbed from gastrointestinal tract. It has reported that these substances possess several biological effects in which inhibitory property involved in membrane transports and mitochondrial functions is considered to be important for their action. Testing of parabens has revealed that estrogen-like activities of these chemicals are much less potent than natural estrogen, 17β estradiol (E2). Additionally, the estrogenicity of individual paraben- compounds is distinct depending upon their biochemical structure. Recent findings of paraben-estrogenic activities have shown that these compounds may affect breast cancer incidence in women, suggesting adverse ecological outcomes of this environmental group on human and animal health. Although the biological and toxicological effects of parabens have been demonstrated in many previous studies, possible mechanism(s) of their action are required to be explored in order to bring the better understanding in the detrimental impacts of parabens in human and wildlife. There have several different types of parabens which are the most widely used as preservatives. These include methylparaben, ethylparaben, propylparaben, butylparaben and p-hydroxybenzoic acid, a major metabolite of parabens. In this review, we summarize current database based on in vitro and in vivo assays for estrogenic activities and health risk assessment of paraben- EDs which have been published previously.
Endocrine Disrupting Activities of Parabens: An Overview of Current Databases on Their Estrogenicity
Dang, Vu Hoang,Jeung, Eui-Bae 韓國受精卵移植學會 2008 한국동물생명공학회지 Vol.23 No.4
Recently, parabens have been believed to act as xenoestrogens, an identified class of endocrine disruptors (EDs). These environmental compounds are the most well-known as preservatives in many commercial products, including food, cosmetics and pharmaceutical industries. It has been demonstrated that the human health risks of parabens result from a long-term exposure to skin in which this chemical group is rapidly absorbed through the skin. On the other hand, parabens are also completely absorbed from gastrointestinal tract. It has reported that these substances possess several biological effects in which inhibitory property involved in membrane transports and mitochondrial functions is considered to be important for their action. Testing of parabens has revealed that estrogen-like activities of these chemicals are much less potent than natural estrogen, estradiol (E2). Additionally, the estrogenicity of individual paraben- compounds is distinct depending upon their biochemical structure. Recent findings of paraben-estrogenic activities have shown that these compounds may affect breast cancer incidence in women, suggesting adverse ecological outcomes of this environmental group on human and animal health. Although the biological and toxicological effects of parabens have been demonstrated in many previous studies, possible mechanism(s) of their action are required to be explored in order to bring the better understanding in the detrimental impacts of parabens in human and wildlife. There have several different types of parabens which are the most widely used as preservatives. These include methyl-paraben, ethylparaben, propylparaben, butylparaben and p-hydroxybenzoic acid, a major metabolite of parabens. In this review, we summarize current database based on in vitro and in vivo assays for estrogenic activities and health risk assessment of paraben- EDs which have been published previously.
DANG, Vu Hoang,CHOI, Kyung-Chul,JEUNG, Eui-Bae Society for Reproduction and Development 2009 Journal of Reproduction and Development Vol.55 No.2
<P>Growth hormone (GH) plays a pivotal role in the regulation of growth, development and body composition. In order to provide new insights into estrogenic endocrine disruptor (ED) activities in the pituitary gland and the potential role played by estrogen receptors (ERs) in mediating their effects <I>in vivo</I>, we examined <I>GH</I> expression in the pituitary gland of an immature rat model. At postnatal day 14, immature rats were treated with various doses of <I>4-tert</I>-octylphenol (OP), <I>p</I>-nonylphenol (NP) and bisphenol A (BPA), and the <I>GH</I> mRNA and protein expression levels were analyzed by real-time quantitative PCR and western blot/immunohistochemistry (IHC), respectively. An anti-estrogen (ICI 182780) was used to examine the potential involvement of ERs in ED-induced GH expression during critical windows of development. <I>GH</I> mRNA expression increased significantly 48 h after treatment with a high dose (600 mg/kg body weight [BW]) of OP or NP. However, this induction was abolished completely by co-treatment with ICI 182780. No significant difference in <I>GH</I> mRNA expression was observed following treatment with BPA or co-treatment of BPA with the anti-estrogen. Exposure to high doses (600 mg/kg BW) of these EDs significantly enhanced GH protein expression in the rat pituitary gland, whereas pretreatment with ICI 182780 markedly reduced this expression. Taken together, we have demonstrated for the first time that <I>in vivo</I> exposure to EDs can induce <I>GH</I> mRNA and protein expression in the rat pituitary gland and that their activities may involve an ER-mediated signaling pathway. These results may provide critical evidence for ED-induced dysregulation of pituitary GH expression and thus may be important for elucidating the potential impacts of EDs in altered body growth and development and for predicting the health risks of ED exposure in humans and wildlife.</P>
Dang, Vu Hoang,Choi, Kyung-Chul,Hyun, Sang-Hwan,Jeung, Eui-Bae TAYLOR & FRANCIS 2007 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH PAR Vol.70 No.2
<P> Various environmental chemicals, both natural and synthetic, are believed to act as endocrine disruptors (EDs) in mammals. In this study, a new in vivo model of immature rats was used to explore the induction of calbindin-D9k (CaBP-9k) following a single injection of EDs. In a time-dependent experiment, immature rats at postnatal day 16 were treated with high doses (600 mg/kg body weight [BW]) of 4-tert-octyphenol (OP), p-nonylphenol (NP), or bisphenol A (BPA), and euthanized at different time points (3, 6, 12, 24, or 48 h). For a dose-dependent study, immature rats were given different doses (200, 400, or 600 mg/kg BW) and euthanized at 24 h after injection. After treatment with these EDs, the effects on CaBP-9k mRNA and protein were examined by Northern and Western blot analyses, respectively. An anti-estrogen, ICI 182,780, was employed to examine the potential involvement of estrogen receptor (ER) in the induction of estrogen receptor-mediated physiologic responses in vivo. A single treatment with each of the chemicals, at 600 mg/kg BW, resulted in a significant increase in the expression of CaBP-9k mRNA and protein 24 h after injection. In addition, treatment with OP, NP, or BPA resulted in a positive uterotrophic response. Cotreatment with the ER antagonist ICI 182,780 completely prevented the ED-induced uterine weight gain. Taken together, these results demonstrate that a single injection of OP, NP, or BPA results in an increase of CaBP-9k mRNA and protein via an ER-dependent pathway in the uterus of immature rats. This new model may be important to elucidate the mechanism of action of xenoestrogens on estrogen-sensitive tissue.</P>
Hoang Vu Dao,Xuan Dinh To,Hoai Vu Anh Truong,Tri-Cuong Do,Cong Minh Ho,Tri Dung Dang,안경관 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.4
Fuel cell hybrid electric construction equipment (FCHECE) is known as a promising solution to achieve the goal of energy saving and environment protection. Energy management strategy is a key technology of FCHECE, which splits the energy fl ow between power sources. This paper presents a novel optimal energy management strategy for a hybrid electric-powered hydraulic excavator system to enhance power performance, power sources lifespan, and fuel economy. As for the proposed powertrain configuration, fuel cell serves as a primary energy source, and supercapacitor and battery are considered as energy storages. The integration of supercapacitor and battery in fuel cell vehicle has advantages of improving power performance and storing the regenerative energy for future usage. An energy management strategy based on fuzzy logic control and a rule-based algorithm is proposed to effectively distribute the power between the three sources and reuse the regenerative energy. Furthermore, the parameters of the fuzzy logic system are optimized using the combination of a backtracking search algorithm which provides a good direction to the global optimal region and sequential dynamic programming as a local search method to fi ne-tune the optimal solution in order to reduce the hydrogen consumption and prolong the lifetime of the power sources. Simulation results show that the proposed energy management strategy enhances the vehicle performance, improves fuel economy of the FCHECE by 10.919%, increase battery and supercapacitor charge-sustaining capability as well as efficiency of the fuel cell system.