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노호식 ( Ho Sik Rho ),백흥수 ( Heung Soo Baek ),김수정 ( Sujong Kim ),김수남 ( Sunam Kim ),김덕희 ( Duck Hee Kim ),장이섭 ( Ih Seop Chang ),이옥섭 ( Ok-sub Lee ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.3
레티노이드 효과가 나타나는 것을 목적으로 하여 다양한 히드록삼산 유도체를 합성하였고, 레티노익산 수용체에 대한 전사 활성을 측정하여 스크리닝하였다. 합성된 화합물 중에서 N-(4-N-hydroxycarbamoyl)phenyl) [4-(tort-butyl)phenyl] carboxamide (2f)가 수용체에 대한 가장 강력한 적합성을 나타내었다. 히드록삼산 구조에서 산도를 나타내는 히드록시기는 쉽게 이온화하여 음이온을 형성한다. 형성된 히드록삼산의 음이온은 레티노익산의 음이온과 유사한 역할을 한다. 이와 같이 히드록삼산 화합물이 레티노이드 효과를 나타내는 예는 이전에 알려진 바가 없다. 화합물 2f의 레티노이드 효과는 레티노이드와 연관된 유전자의 발현 증가 효과로 한번 더 검증하였다. 노화 원료로서의 가능성을 확인하기 위해서 MMP-1의 발현 억제능을 레티노익산, 레티놀과 비교하여 살펴보았다. 10 μM 농도에서 화합물 2f는 MMP-1의 발현을 억제하였다. 이와 같은 결과로 화합물 2f는 항노화 원료로서의 가능성을 가지고 있다. Several hydroxamic acid derivatives are synthesized to observe retinoidal effect and transactivation potential for RARα/γ is screened. Among the synthesized compounds, N-(4-N-hydroxycarbamoyl )phenyl) [4-(tert-butyl )phenyl] carboxamide (2f) showed the best compatibility for potent RARα/γ. The acidic hydroxy of hydroxamic acid was easily deprotonated to form an enolate. A formed enolate has a similar role like that of all-trans-retinoic acid. This is the first example of the hydroxamic acid derivative with retinoidal activity. The retinoidal activity of 2f was further confirmed by enhancing activity for the expression of retinoid-responsive genes. To evaluate the possibility for anti.-aging agent, effect on the expression of MMP-1 was measured comparing with all-trans-retinoic acid and retinol. At 10 μM treatment, compound 2f inhibited the expression of MMP-1. These results suggest that new hydroxamic acid derivative 2f could be used as a promising anti-aging agent.
조가영,노호식,김은주,문은정,김지성,박혜윤,김덕희,김한곤,Cho, Ga-Young,Rho, Ho-Sik,Kim, Eun-Joo,Moon, Eun-Jeong,Kim, Ji-Seong,Park, Hye-Yoon,Kim, Duck-Hee,Kim, Han-Gon 대한한의정보학회 2009 大韓韓醫情報學會誌 Vol.15 No.1
Objectives : The aim of the present study is to evaluate the wound healing-enhancing and anti-inflammatory effects of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensison human keratinocyte, HaCaT cells. Methods : We adopted in vitro wound healing assay to measure the proliferation-and migration-enhancing effects in HaCaT cells. The expressions of cytokine genes were measured in HaCaT cells using real-time PCR analysis. Results : The extracts of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis enhanced the proliferation and migration of HaCaTcells. The expression of keratinocyte growth factor receptor(FGFR2-IIIb) gene was also induced. The extracts inhibited iNOS, IL-$1{\beta}$ and TNF-$\alpha$ gene expression. Conclusions : The extract of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis has wound healing-enhancing effects and anti-inflammatory effects.
메조-디하이드로구아레틱산 메틸, 아세틸 치환체의 합성 및 이들 화합물들의 LPS에 의해서 유도된 일산화질소(NO)의 억제 효능에 대한 연구
최경오 ( Kyungoh Choi ),노호식 ( Ho Sik Rho ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.3
본 연구는 메조-디하이드로구아레틱산(MDGA, 1)과 합성 유도체(2와 3)의 일산화질소(NO)억제 효능에 대한 내용이다. MDGA는 토후박(Machilus thunbergii Sieb. et Zucc.)껍질에서 분리된 리그난 화합물이다. 본 연구자들은 디메틸로 치환된 화합물(2)과 디아세틸로 치환된 화합물(3)을 합성하였고, 이 두 화합물의 일산화질소 억제 효능을 MDGA (1)와 비교하여 측정하였다. MDGA (1)와 화합물(3)은 LPS에 의해서 유도된 일산화질소 억제 효능을 나타내었다. RT-PCR 분석을 통해 MDGA (1)와 화합물(3)의 일산화질소 억제 효능은 iNOS의 mRNA 발현의 감소에 기인함을 확인하였다. 이러한 실험 결과로부터 디아세틸로 치환된 화합물(3)은 MDGA의 프로드럭으로 사용될 수 있음을 확인하였다. This study was conducted to examine the inhibitory effects of meso-dihydroguaretic acid (MDGA, 1) and its synthetic derivatives (compound 2 and 3) against NO production. MDGA is a lignan component isolated from the bark of Machilus thunbergii Sieb. et Zucc. We synthesized dimethylated MDGA (2), diacetylated MDGA (3) and compared NO inhibition of two derivatives with that of MDGA (1). MDGA (1) and compound 3 showed suppressive effects against the generation of NO in LPS-activated macrophages. RT-PCR analysis suggested that MDGA (1) and compound 3 inhibited NO production through the suppression of iNOS mRNA expression. From these results, diacetylated MDGA (3) can be used as a pro-drug for MDGA.
경항부 수기요법과 한방 목 크림이 목 주름과 안면 혈행에 미치는 영향 연구
김은주,김지성,유선혜,노호식,김덕희,김한곤,조가영,Kim, Eun-Joo,Kim, Ji-Seong,Yu, Sun-Hye,Rho, Ho-Sik,Kim, Duck-Hee,Kim, Han-Gon,Cho, Ga-Young 대한한의정보학회 2009 大韓韓醫情報學會誌 Vol.15 No.1
Objectives: We investigated the influence of the neck acupressure massage and the neck cream including korean herbal extract on the neck wrinkles and blood circulation. Methods: Korean female($37.47{\pm}3.66$ years, n=18) aged 30-39 years were participated in this study. We measured the neck wrinkles with PRIMOS(GFMesstechnik GmbH, Germany) and blood circulation of neck and facial skin with Laser Doppler Imaging-Periscan PIM II(Perimed AB, Sweden). Results: The neck wrinkles were significantly decreased after applying neck cream. But when with the neck acupressure massage, the neck wrinkles were decreased 2-fold than applying only the neck cream. The skin blood circulation was significantly increased on the neck and facial skin immediately after the neck acupressure massage. But this effect was not significantly different after 8 weeks Conclusions: This result suggests that the neck acupressure massage can improve the anti-wrinkles effect of the neck cream including Korean herbal extract.
한약재 추출물이 지방세포주 3T3-L1 분화에 미치는 영향
김지성,조가영,김은주,박준성,노호식,박혜윤,김덕희,김한곤,Kim, Ji-Seong,Cho, Ga-Young,Kim, Eun-Joo,Park, Jun-Seong,Rho, Ho-Sik,Park, Hye-Yoon,Kim, Duck-Hee,Kim, Han-Gon 대한한의정보학회 2009 大韓韓醫情報學會誌 Vol.15 No.1
Objectives : The aim of the present study is to evaluate the effects Rehmannia glutinosa, Radix puerariae, Semen coicis, Fructus hordei, Cortex acanthopanacis, Fructus chaenomelis, or Radix glycyrrhizae extracton 3T3-L1 preadipocytes differentiation. Methods : We adopted Oil Red O staining methods to observe the formed lipid droplets. And the amount of lipids in adipocytes was measured using absorptiometric analysis. Results : The extracts of Rehmannia glutinosa, Radix puerariae, Semen coicis, Fructus hordei, Cortex acanthopanacis, Fructus chaenomelis, or Radix glycyrrhizae stimulated the preadipocytes differentiation and lipid droplet formation. And the complex extract of the traditional herbal medicines stimulated there actions more than single extracts. Conclusions : The extract of Rehmannia glutinosa, Radix puerariae, Semen coicis, Fructus hordei, Cortex acanthopanacis, Fructus chaenomelis, or Radix glycyrrhizae has stimulatory effects. on adipogenesis. Moreover, the complex extract of the traditional herbal medicines has more effect than single extracts.
백흥수 ( Heung Soo Baek ),안수미 ( Soo Mi Ahn ),우병영 ( Byoung Young Woo ),조영석 ( Young Seok Cho ),최수정 ( Soo Jeong Choi ),노호식 ( Ho Sik Rho ),변경희 ( Kyoung Hee Byoun ),신송석 ( Song Seok Shin ),박영호 ( Young Ho Park 대한화장품학회 2013 대한화장품학회지 Vol.39 No.2
Polyhydroxylated benzamide 유도체의 구조변화에 따른 미백효과의 상관관계를 고찰하였다. Adamantyl benzamide 유도체에서 B ring 부분의 치환기가 catechol (3,4-dihydroxyphenyl)인 경우 우수한 멜라닌 생성 저해활성을 보였으나, mono-hydroxyphenyl (3-OH 또는 4-OH)이거나 3,4-dimethoxyphenyl인 경우에 그 활성이 감소하거나 없어졌다. 따라서 catechol unit이 멜라닌 생성 저해에 중요한 인자임을 알 수 있었다. 그리고 A-ring부분의 2-OH의 존재여부는 활성에 큰 영향을 주지는 않았고, A-ring과 B-ring을 연결하는 탄소사슬의 길이 역시 멜라닌 생성저해에 큰 영향을 주는 요소는 아니었다. The structure activity relationship of polyhydroxylated benzamide derivatives for whitening effects was examined. The adamantyl benzamide derivatives with catechol (3,4-dihydroxyphenyl) of B-ring part showed good anti- melanogenesis activity, but the inhibitory activity of mono-hydroxyphenyl (3-OH or 4-OH) or 3,4-dimethoxyphenyl substituted derivatives was decreased or lost. Therefore the catechol unit was appeared to be the crucial factor for the inhibition of melanogenesis. And the existence of 2-OH of A-ring part had minor influence on the activity, the length of carbon chain between A-ring and B-ring was also not the major factor for the anti-melanogenesis activity.
Kaempferol 및 Kaempferol Rhamnosides의 항산화 활성 및 항염 효과에 관한 연구
이근하 ( Keun Ha Lee ),조영롱 ( Young Long Cho ),주철규 ( Chul Gue Joo ),주연정 ( Yeon Jeong Joo ),권순상 ( Sun Sang Kwon ),안수미 ( Soo Mi Ahn ),오수진 ( Su Jin Oh ),노호식 ( Ho Sik Rho ),박청 ( Chung Park ) 대한화장품학회 2011 대한화장품학회지 Vol.37 No.3
본 연구에서는 kaempferol 및 그 배당체의 항산화 및 항염증 효능을 평가하기 위해 free radical 소거활성, ROS inhibition assay, TARC 생성 억제 관련 실험을 수행하였다. 또한 kaempferol과 그들의 rhamnosides (α-rhamnoisorobin, afzelin, kaempferitrin)의 구조에 따른 생리적 활성의 상관관계를 조사하였다. Kaempferol과 α-rhamnoisorobin은 free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) 소거활성(FSC50)에서 각각 62.5, 50.0 μM이 측정되었으며 afzelin과 kaempferitrin은 농도와 상관없이 free radical 소거활성을 나타내지 않았다. ROS inhibition assay에서는 시료 농도를 10, 50, 100 μM을 처리한 결과 kaempferol은 대조군(100 %)에 비하여 ROS 발현 농도를 각각 97.5, 57.8, 47.8 %로 감소하였으며 α-rhamnoisorobin은 93.1, 59.1, 41.4 %의 감소를 나타내었다. TARC (thymus and activation regualted chemokine) 생성 억제능 실험을 통해 시료의 항염증 효능을 평가한 결과 kaempferol은 10, 50, 100 μM 농도에서 대조군(100 %)에 대비하여 각각 48.8, 5.5, 4.4 %로 농도 의존적으로 TARC 생성을 감소시켰으며, α-rhamnoisorobin은 88.1, 19.0, 1.0 %로 TARC 생성의 감소 효능을 나타내었다. 결론적으로 kaempferol과 그들의 rhamnoside 중 kaempferol과 α-rhamnoisorobin은 항산화, 항염증에 대한 우수한 효능을 나타내는 것으로 사료되며 더 나아가서는 항노화 및 항염증에 효과가 있는 기능성 화장품에 응용 가능성이 있음을 시사한다. In this study, to evaluate the antioxidative activities and anti-inflammatory effects of kaempferol and its rhamnosides, we performed the free radical scavenging assay, ROS inhibition assay and TARC (thymus and activation- regulated chemokine) assay. Also, we studied physiological activity of kaempferol and its rhamnosides (α-rhamnoisorobin, afzelin, kaempferitn) by structure-activity relations. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activities were determined with kaempferol (62.5 μM) and α-rhamnoisorobin (50.0 μM) but afzelin and kaempferitrin did not show free radical scavenging activities. Kaempferol showed a 97.5, 57.8, 47.8 % inhibition of ROS (reactive oxygen species) generated at concentrations of 10, 50 and 100 μM, compared to control (100 %). α-rhamnoisorobin showed a 93.1, 59.1 and 41.4 % inhibition of ROS at the same concentration. We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC expression. Kaempferol showed a 48.8, 5.5 and 4.4 % inhibition of TARC generated at 10, 50 and 100 μM, compared to control. α-Rhamnoisorobin showed a 88.1, 19.0 and 1.0 % inhibition of TARC generated at the same concentration. In conclusion, these results indicate that kaempferol and α-rhamnoisorobin have good antioxidative activities and anti-inflammatory effects that could be applicable to new functional cosmetics for anti-aging and anti-inflammation.