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Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Anti-inflammatory components of the Vietnamese starfish <i>Protoreaster nodosus</i>
Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Koo, Jung Eun,Kim, Sohyun,Koh, Young Sang,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Van Kiem, Phan,Kim, Young Ho,Van Minh, Chau BioMed Central 2015 Biological research Vol.48 No.1
<P><B>Background</B></P><P>In the present study, we examined the inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols <B>(1–4)</B> isolated from the Vietnamese starfish <I>Protoreaster nodosus</I> on pro-inflammatory cytokine (IL-12 p40, IL-6, and TNF-α) production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) using enzyme-linked immunosorbent assays (ELISA).</P><P><B>Results</B></P><P>The methanolic extract and dichloromethane fraction exerted potent inhibitory effects on the production of all three pro-inflammatory cytokines, with IC<SUB>50</SUB> values ranging from 0.60 ± 0.01 to 26.19 ± 0.64 μg/mL. Four highly pure steroid derivatives <B>(1–4)</B> were isolated from the dichloromethane fraction and water layer of <I>P. nodosus</I>. Potent inhibitory activities were also observed for (25<I>S</I>) 5α-cholestane-3β,4β,6α,7α,8β,15α,16β,26-octol <B>(3)</B> on the production of IL-12 p40 and IL-6 (IC<SUB>50s</SUB> = 3.11 ± 0.08 and 1.35 ± 0.03 μM), and for (25<I>S</I>) 5α-cholestane-3β,6α,8β,15α,16β,26-hexol <B>(1)</B> and (25<I>S</I>) 5α-cholestane-3β,6α,7α,8β,15α,16β,26-heptol <B>(2)</B> on the production of IL-12 p40 (IC<SUB>50s</SUB> = 0.01 ± 0.00 and 1.02 ± 0.01 μM). Moreover, nodososide <B>(4)</B> exhibited moderate inhibitory effects on IL-12 p40 and IL-6 production.</P><P><B>Conclusion</B></P><P>This is the first report of the anti-inflammatory activity from the starfish <I>P. nodosus</I>. The main finding of this study is the identification oxygenated steroid derivatives from <I>P. nodosus</I> with potent anti-inflammatory activities that may be developed as therapeutic agents for inflammatory diseases.</P>
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol.62 No.2
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van WILEY‐VCH Verlag 2014 Chem Inform Vol.45 No.28
<P><B>Abstract</B></P><P>isolation, structure determination and antiinflammatory effects of nine cembranoid diterpenes including four new compounds, crassumols D—G (I)—(IV), respectively</P>
Evaluation of $alpha$-decay Half-life for Measuring Concentration of Radioactive Nuclei
Nguyen Ngoc Duy,Phuong-Thao Ho 한국물리학회 2020 New Physics: Sae Mulli Vol.70 No.5
In this study, we employed the semi-empirical formulae proposed by Viola-Seaborg, Royer, and Poenaru to estimate the -decay half-lives of the radioactive isotopes in the 235;238U chains because they are important for alpha analysis and radioprotection. We found a large uncertainty of about two orders of magnitude, in the experimental data for the half-lives, as evaluated by using each model. The results showed that the current formulae are insufficient for isotopes that undergo a multi-decay mode or -decay probability less than 1:5%. The relations between the estimated halflives and the experimental data in NuDat Database were deduced as linear functions to improve the validity of the semi-empirical models. The large radioactivity uncertainty due to the half-lives calculated by using the three models should be a concerned for the analysis of the radioactive isotopes using alpha spectrometers. On the other hand, an approach for estimating sample sizes based on the -decay half-life in concentration analyses using alpha analysts is proposed for measurements of largely uncertain or unknown half-life isotopes.