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Ota, Miho,Ogura, Jun,Ogawa, Shintaro,Kato, Koichi,Matsuda, Hiroshi,Kunugi, Hiroshi 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.3
Purpose Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods Ten adult male Fischer F344 rats underwent [$^{11}C$]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [$^{11}C$]PK11195 between before and after injection was determined. Results There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [$^{11}C$]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [$^{11}C$]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Miho Ota,Junko Matsuo,Noriko Sato,Toshiya Teraishi,Hiroaki Hori,Kotaro Hattori,Yoko Kamio,Norihide Maikusa,Hiroshi Matsuda,Hiroshi Kunugi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11
Objective Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.
Miho Ota,Junko Matsuo,Noriko Sato,Toshiya Teraishi,Hiroaki Hori,Kotaro Hattori,Yoko Kamio,Norihide Maikusa,Hiroshi Matsuda,Hiroshi Kunugi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.10
Objective: Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. Methods: Subjects were 41 healthy male subjects who underwent the social responsiveness scale-adult (SRS-A) and magnetic resonance imaging. Results: There was significant positive correlation between the total score of SRS-A and the regional cerebral blood flow (CBF) in posterior cingulate cortex (PCC). Also, there were changes in functional network such as in cingulate corti, insula and fusiform cortex. Further, we also found the significant difference of functional networks between the healthy male subjects with high or low autistic spectrum trait, and these points were congruent with the previous perceptions derived from autistic-spectrum disorders. Conclusion: These findings suggest a biological basis for the autistic spectrum trait and may be useful for the imaging marker of autism symptomatology.