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Transaplantation of neural stem cells into the spinal cord after injury
Okano, Hideyuki,Ogawa, Yuto,Nakamura, Masaya,Kaneko, Shinjiro,Iwanami, Akio,Toyama, Yoshiaki 한림대학교 환경·생명과학연구소 2003 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.5
Thanks to advances in the stem cell biology of the central nervous system (CNS), the previously inconceivable regeneration of the damaged CNS is approaching reality. The availability of signals to induce the appropriate differentiation of the transplanted and/or endogenous neural stem cells(NSCs) as well as the timing of the transplantation are important for successful functional recovery of the damaged CNS. Because the immediately post-traumatic microenvironment of the spinal cord is in an acute inflammatory stage, it is not favorable for the survival and differentiation of NSC transplants. On the other hand, in the chronic stage after injury, glial scars form in the injured site that inhibit the regeneration of neuronal axons. Thus, we believe that the optimal timing of transplantation is 1-2 weeks after injury.
Takahiro Kitagawa,Narihito Nagoshi,Hideyuki Okano,Masaya Nakamura 대한척추신경외과학회 2022 Neurospine Vol.19 No.4
A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in neurological function because of poor regenerative potential. Transplantation therapies have attracted attention for restoration of the injured spinal cord, and transplantation of neural precursor cells (NPCs) has been studied worldwide. Several groups have demonstrated functional recovery via this therapeutic intervention due to the multiple beneficial effects of NPC transplantation, such as reconstruction of neuronal circuits, remyelination of axons, and neuroprotection by trophic factors. Our group developed a method to induce NPCs from human induced pluripotent stem cells (hiPSCs) and established a transplantation strategy for SCI. Functional improvement in SCI animals treated with hiPSC-NPCs was observed, and the safety of transplanting these cells was evaluated from multiple perspectives. With selection of a safe cell line and pretreatment of the cells to encourage maturation and differentiation, hiPSC-NPC transplantation therapy is now in the clinical phase of testing for subacute SCI. In addition, a research challenge will be to expand the efficacy of transplantation therapy for chronic SCI. More comprehensive strategies involving combination treatments are required to treat this problematic situation.
Ultrahigh-speed distributed Brillouin reflectometry
Mizuno, Yosuke,Hayashi, Neisei,Fukuda, Hideyuki,Song, Kwang Yong,Nakamura, Kentaro Nature Publishing Group 2016 Light, science & applications Vol.5 No.12
<P>Optical fibre sensors based on Brillouin scattering have been vigorously studied in the context of structural health monitoring on account of their capacity for distributed strain and temperature measurements. However, real-time distributed strain measurement has been achieved only for two-end-access systems; such systems reduce the degree of freedom in embedding the sensors into structures, and furthermore render the measurement no longer feasible when extremely high loss or breakage occurs at a point along the sensing fibre. Here, we demonstrate real-time distributed measurement with an intrinsically one-end-access reflectometry configuration by using a correlation-domain technique. In this method, the Brillouin gain spectrum is obtained at high speed using a voltage-controlled oscillator, and the Brillouin frequency shift is converted into a phase delay of a synchronous sinusoidal waveform; the phase delay is subsequently converted into a voltage, which can be directly measured. When a single-point measurement is performed at an arbitrary position, a strain sampling rate of up to 100 kHz is experimentally verified by detecting locally applied dynamic strain at 1 kHz. When distributed measurements are performed at 100 points with 10 times averaging, a repetition rate of 100 Hz is verified by tracking a mechanical wave propagating along the fibre. Some drawbacks of this ultrahigh-speed configuration, including the reduced measurement accuracy, lowered spatial resolution and limited strain dynamic range, are also discussed.</P>