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Medaka Fish Parkinson’s Disease Model
Hideaki Matsui,Roberto Gavinio,Ryosuke Takahashi2 한국뇌신경과학회 2012 Experimental Neurobiology Vol.21 No.3
The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson’s disease (PD) models we developed using toxin treatment and genetic engineering. 1-Methyl-4-phenyl-1,2,3,4–tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), proteasome inhibitors, lysosome inhibitors and tunicamycin treatment in our model fish replicated some salient features of PD: selective dopamine cell loss and reduced spontaneous movement with the last three toxins producing inclusion bodies ubiquitously in the brain. Despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. PTEN-induced putative kinase 1 (PINK1) homozygous mutants also showed reduced spontaneous swimming movements. These data indicate that medaka fish can serve as a new model animal of PD. In this review we summarize our previous data and discuss future prospects
Hideaki Takahashi,Hiroyoshi Naito 한국물리학회 2006 Current Applied Physics Vol.6 No.5
Amplied spontaneous emission from optically pumped thin-lm waveguides of poly(9,9-dioctyluorene) (F8) has been mea-sured to study the inuence of interface roughness on transmission loss within F8 waveguides. It is found that the transmission losscoecient at the emission wavelength is reduced with increasing thickness of the waveguides. A theoretical model is employed toexplain the relationship between the transmission loss of F8 waveguides and their thickness. The model explains the relationshipfound experimentally. A major source of loss is shown to be due to nanometer-size interface roughness of F8 waveguides. Suchinformation is valuable for the design of organic solid-state lasers.
Velocity Estimation of Multiple Objects using Oculomotor System
Hideaki Takahashi,Teruo Yamaguchi,Hiroshi Harada 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
In the previous research, we proposed an oculomotor system which expanded the limits of velocity measurement using spatiotemporal differentiation method. It was proved that the accurate optical flow was estimated at large object velocity by using this system. In this paper, we propose optical flow estimation method using oculomotor system where multiple objects on image move independently at large velocity. We suggest applying oculomotor system separately to regions of the same object motion. Using this approach, high accuracy of optical flow estimation can be obtained in case of multiple objects on image moving independently at a large velocity.
Takahashi, Hideaki,Rikimaru, Kazuhiro,Komatsu, Megumi,Uemoto, Yoshinobu,Suzuki, Keiichi Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.3
We previously identified quantitative trait loci (QTL) for body weight and average daily gain in a common region between ADL0198 (chr 1: 171.7 Mb) and ABR0287 (chr 1: 173.4 Mb) on chicken chromosome 1 in an $F_2$ resource population produced by crossing low- and high-growth lines of the Hinai-dori breed. Motilin receptor (MLNR) is a candidate gene affecting growth traits in the region. In this study, we genotyped polymorphisms of the MLNR gene and investigated its association with growth traits in a Hinai-dori $F_2$ intercross population. All the exons of the MLNR gene in the parental population were subjected to PCR amplification, nucleotide sequenced and haplotypes identified. To distinguish resultant diplotype individuals in the $F_2$ population, a mismatch amplification mutation assay was performed. Three haplotypes (Haplotypes 1-3) were accordingly identified. Six genotypes produced by the combination of three haplotypes (Haplotype 1, 2, and 3) were examined in order to identify associations between MLNR haplotypes and growth traits. The data showed that Haplotype 1 was superior to Haplotype 2 and 3 in body weight at 10 and 14 weeks of age, average daily gain between 4 and 10 weeks, 10 and 14 weeks, and 0 and 14 weeks of age in female in $F_2$ females. It was concluded that MLNR is a useful marker of growth traits and could be used to develop strategies for improving growth traits in the Hinai-dori breed.