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Hewage, Susara Ruwan Kumara Madduma,Piao, Mei Jing,Kang, Kyoung Ah,Ryu, Yea Seong,Fernando, Pattage Madushan Dilhara Jayatissa,Oh, Min Chang,Park, Jeong Eon,Shilnikova, Kristina,Moon, Yu Jin,Shin, Dae The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.4
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.
Hewage, Susara Ruwan Kumara Madduma,Piao, Mei Jing,Kang, Kyoung Ah,Ryu, Yea Seong,Han, Xia,Oh, Min Chang,Jung, Uhee,Kim, In Gyu,Hyun, Jin Won The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.3
Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin ($C_{28}H_{34}O_{15}$) to prevent apoptosis due to oxidative stress generated through UVB-induced ROS. Hesperidin significantly scavenged ROS generated by UVB radiation, attenuated the oxidation of cellular macromolecules, established mitochondrial membrane polarization, and prevented the release of cytochrome c into the cytosol. Hesperidin downregulated expression of caspase-9, caspase-3, and Bcl-2-associated X protein, and upregulated expression of B-cell lymphoma 2. Hesperidin absorbed wavelengths of light within the UVB range. In summary, hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis via its antioxidant and UVB absorption properties.
Urumutta Hewage Ganga S.,Klucarova Sona,Boman Laura 한국마케팅과학회 2021 Journal of Global Fashion Marketing Vol.12 No.4
From the lens of conspicuous consumption, this research examines the interactive effect of brand logo size and political ideology on consumers’ intentions toward fashion products. Specifically, in a series of four studies, we address how consumer political ideology influences intentions toward items displaying smaller, inconspicuous logos versus larger, conspicuous logos for unfamiliar and familiar brands. We show that liberal consumers are more likely to prefer a large (rather than small) logo when a brand is unfamiliar. We suggest that liberals’ greater desire for product uniqueness elevates their risk propensity, which in turn increases preference for conspicuous consumption when familiarity with a brand is low. We show that this effect occurs only for unfamiliar brands; when brand familiarity is high (i.e. a popular or well-known brand), consumer political ideology reverses consumer preference for conspicuous consumption, replicating prior work. Our results suggest that, by manipulating their logo size, new brands may effectively target consumers based on their political ideology.
Herath, Kalahe Hewage Iresha Nadeeka Madushani,Bing, So Jin,Cho, Jinhee,Kim, Areum,Shin, Sumin,Kim, Gi-Ok,Lee, Jong-chul,Jee, Youngheun EDITIONS SCIENTIFIQUES ELSEVIER 2016 BIOMEDICINE AND PHARMACOTHERAPY Vol.83 No.-
<P><B>Abstract<ce:cross-ref refid='fn0005'> <SUP>2</SUP> </ce:cross-ref> </B></P> <P>Dangyuja (<I>Citrus grandis</I> Osbeck), a citrus cultivated in southern Korea, has been used in traditional medicine for its anti-inflammatory effect. In this study, we investigated the anti-inflammatory potential of extract of <I>Citrus grandis</I> Osbeck (ECGO). In <I>in vitro</I> assays, ECGO treatment of concanavalin A (10μg/ml, for 24h) stimulated splenocytes showed significant reduction in CD44/CD62L<SUP>+</SUP> T cell population and a marked decrease in the production of inflammatory cytokines IL-2, IFN-γ and IL-4. Interestingly, <I>in vivo</I> assays of ECGO topical treatment (100μg/20μl/ear) significantly mitigated the TPA (4μg/20μl/ear) induced edema induction and Myeloperoxidase activity. Anti-inflammatory potential of ECGO were further evidenced through its potent decrease in expression of inducible nitric oxide, cyclooxygenase-2, IL-1β and TNF-α and suppressed homing of CD3<SUP>+</SUP> T cells and F4/80<SUP>+</SUP> macrophages to site of inflammation. This study emphasizes the possibility of developing ECGO as an alternative natural topical agent to combat inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Anti-inflammatory potentials of citrus Dangyuja. </LI> <LI> Topical treatment of ECGO attenuates skin edema. </LI> <LI> ECGO down regulates the pro-inflammatory mediators; iNOS and COX2 to site of inflammation. </LI> </UL> </P>