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Heejung Jo,Mani Gajendiran,김교범 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.82 No.-
The polycation/polyanion based coacervate platform for therapeutic protein deliveryfinds difficulty intheir colloidal stability under physiological environment. To overcome this issue, PEGylation could be aversatile strategy to enhance colloidal stability. Herein, a poly(ethylene arginyl aspartate diglyceride)(PEAD) polycation was synthesized, and a series of methoxy polyethylene glycols (mPEG) includingmPEG350, mPEG750 and mPEG2000 were attached with PEAD polycation to obtain mPEG350-PEAD,mPEG750-PEAD and mPEG2000-PEAD respectively. The PEAD and mPEGylated PEADs were complexedwith heparin (HEP) to fabricate coacervate (Coa) and coacersome (mP_Coa) particles respectively. Thecolloidal stability of Coa and mP_Coa coacersomes has been investigated by dynamic light scattering(DLS) and microscopic techniques. The vascular endothelial growth factor 165 (VEGF-165) wasencapsulated in the Coa or mP_Coa particles and administered to human umbilical vein endothelial cells(HUVECs) to induce a tubular network formation in vitro. All the polycations are highly biocompatible andexhibit more than 94 % of VEGF-165 loading efficiency. An effect of mPEG chain length on colloidalstability of mP_Coa and in vitro tubular formation ability of HUVECs has been investigated.
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Jo, Seonmi,Yarishkin, Oleg,Hwang, Yu Jin,Chun, Ye Eun,Park, Mijeong,Woo, Dong Ho,Bae, Jin Young,Kim, Taekeun,Lee, Jaekwang,Chun, Heejung,Park, Hyun Jung,Lee, Da Yong,Hong, Jinpyo,Kim, Hye Yun,Oh, Soo- Nature Publishing Group, a division of Macmillan P 2014 Nature medicine Vol.20 No.8
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been observed around amyloid plaques since the disease was first described, their role in memory impairment has been poorly understood. Here, we show that reactive astrocytes aberrantly and abundantly produce the inhibitory gliotransmitter GABA by monoamine oxidase-B (Maob) and abnormally release GABA through the bestrophin 1 channel. In the dentate gyrus of mouse models of AD, the released GABA reduces spike probability of granule cells by acting on presynaptic GABA receptors. Suppressing GABA production or release from reactive astrocytes fully restores the impaired spike probability, synaptic plasticity, and learning and memory in the mice. In the postmortem brain of individuals with AD, astrocytic GABA and MAOB are significantly upregulated. We propose that selective inhibition of astrocytic GABA synthesis or release may serve as an effective therapeutic strategy for treating memory impairment in AD.
Cho, Heejung,Song, Eun-Sung,Lee, Young Kee,Lee, Seungdon,Lee, Seon-Woo,Jo, Ara,Lee, Byoung-Moo,Kim, Jeong-Gu,Hwang, Ingyu The Korean Society of Plant Pathology 2018 Plant Pathology Journal Vol.34 No.1
The Ralstonia solanacearum species complex (RSSC) can be divided into four phylotypes, and includes phenotypically diverse bacterial strains that cause bacterial wilt on various host plants. This study used 93 RSSC isolates responsible for potato bacterial wilt in Korea, and investigated their phylogenetic relatedness based on the analysis of phylotype, biovar, and host range. Of the 93 isolates, twenty-two were identified as biovar 2, eight as biovar 3, and sixty-three as biovar 4. Applied to the phylotype scheme, biovar 3 and 4 isolates belonged to phylotype I, and biovar 2 isolates belonged to phylotype IV. This classification was consistent with phylogenetic trees based on 16S rRNA and egl gene sequences, in which biovar 3 and 4 isolates clustered to phylotype I, and biovar 2 isolates clustered to phylotype IV. Korean biovar 2 isolates were distinct from biovar 3 and 4 isolates pathologically as well as genetically - all biovar 2 isolates were nonpathogenic to peppers. Additionally, in host-determining assays, we found uncommon strains among biovar 2 of phylotype IV, which were the tomato-nonpathogenic strains. Since tomatoes are known to be highly susceptible to RSSC, to the best of our knowledge this is the first report of tomato-nonpathogenic potato strains. These results imply the potential prevalence of greater RSSC diversity in terms of host range than would be predicted based on phylogenetic analysis.
Association Between Knowledge and Attitude About Aging and Life Satisfaction Among Older Koreans
Soonrim Suh,Heejung Choi,Choonji Lee,Miyoun Cha,Inhee Jo 한국간호과학회 2012 Asian Nursing Research Vol.6 No.3
Purpose: The purpose of this study was to measure knowledge and attitude about aging and life satisfaction among older Korean adults and to examine the influence of attitude and knowledge about aging on these adults’ life satisfaction. Methods: A cross-sectional and correlational design was used. A total of 405 older adults were surveyed using a written questionnaire at six elderly welfare centers in a metropolitan city in South Korea in mid April 2011. The data were analyzed using descriptive statistics, Pearson’s correlation analysis, and multiple regression. Results: The score of knowledge on aging was below the medium level. Attitude about aging was neutral, and life satisfaction was at the medium level. Variables such as female sex, age, economic status, monthly allowance, living with a spouse, self-rated overall health, knowledge and attitude about aging accounted for 33.8% of the total variance in predicting life satisfaction of the older adults. Older age and lower economic status reduced life satisfaction. Being female, having a monthly income of 300,000 Korea Republic Won or more, living with a spouse, and better knowledge and attitude about aging were associated with enhanced life satisfaction. Conclusion: The effect of knowledge and attitude about aging on life satisfaction is significant. Economic status, living with a spouse and self-rated overall health status are also predictive factors in life satisfaction. Consequently, nursing interventions for education and psychological support to increase knowledge about aging and induce a positive attitude towards it should be developed to improve older adults’ life satisfaction. Purpose: The purpose of this study was to measure knowledge and attitude about aging and life satisfaction among older Korean adults and to examine the influence of attitude and knowledge about aging on these adults’ life satisfaction. Methods: A cross-sectional and correlational design was used. A total of 405 older adults were surveyed using a written questionnaire at six elderly welfare centers in a metropolitan city in South Korea in mid April 2011. The data were analyzed using descriptive statistics, Pearson’s correlation analysis, and multiple regression. Results: The score of knowledge on aging was below the medium level. Attitude about aging was neutral, and life satisfaction was at the medium level. Variables such as female sex, age, economic status, monthly allowance, living with a spouse, self-rated overall health, knowledge and attitude about aging accounted for 33.8% of the total variance in predicting life satisfaction of the older adults. Older age and lower economic status reduced life satisfaction. Being female, having a monthly income of 300,000 Korea Republic Won or more, living with a spouse, and better knowledge and attitude about aging were associated with enhanced life satisfaction. Conclusion: The effect of knowledge and attitude about aging on life satisfaction is significant. Economic status, living with a spouse and self-rated overall health status are also predictive factors in life satisfaction. Consequently, nursing interventions for education and psychological support to increase knowledge about aging and induce a positive attitude towards it should be developed to improve older adults’ life satisfaction.