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Flavonoids from the Whole Plants of Orostachys japonicus
Park, Hee-Juhn,Young, Han-Suk,Park, Kun-Young,Rhee, Sook-Hee,Chung, Hae-Young,Choi, Jae-Sue The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.2
From the whole plants of Orostachys japonicus, kaempferol, quercetin, astragalin, quercitrin, isoquercitrin, cynaroside, afzelin, 3-O-$\alpha$-rhamnosyl-7-$\beta$-D-glucosyl kaempferol, and 3, 7-di-O-$\beta$-D-glucosyl kaempferol were isolated and characterized by spectral data.
Park, Young-Mi,Won, Jong-Heon,Kim, Yang-Hee,Choi, Jong-Won,Park, Hee-Juhn,Lee, Kyung-Tae EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
The mushroom Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae), has been traditionally used for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes in Russia, Poland and most of Baltic countries. This study was designed to investigate the anti-inflammatory and anti-nociceptive effects of the methanol extract from Inonotus obliquus (MEIO) in vivo and in vitro. MEIO (100 or 200㎎/(㎏ day),p.o.) reduced acute paw edema induced by carrageenin in rats, and showed analgesic activity, as determined by an acetic acid-induced abdominal constriction test and a hot plate test in mice. To reveal the mechanism of the anti-inflammatory effect of MEIO, we examined its effect on lipopolysaccharide (LPS)-induced responses in a murine macrophage cell line RAW 264.7. MEIO was found to significantly inhibit the productions of nitric oxide (NO), prostaglandin E_(2) (PGE_(2)) and tumor necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages. Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, MEIO inhibited the LPS-induced DNA binding activity of nuclear factor-κB (NF-κB), and this was associated with the prevention of inhibitor κB degradation and a reduction in nuclear p65 protein levels. Taken together, our data indicate that the anti-inflammatory and anti-nociceptive properties of MEIO may be due to the inhibition of iNOS and COX-2 expression via the down-regulation of NF-κB binding activity.
Anti-inflammatory and Anti-nociceptive Effects of the Methanol Extract of Fomes fomentarius
PARK, Young-Mi,KIM, In-Tae,PARK, Hee-Juhn,CHOI, Jong-Won,PARK, Kun-Young,LEE, Jae-Dong,NAM, Byung-Hyouk,KIM, Deog-Gon,LEE, Jin-Yong,LEE, Kyung-Tae WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
In an attempt to find bioactive natural products with an anti-inflammatory activity, we evaluated the effects of the methanol extract of Fomes fomentarius (MEFF) on in vivo anti-inflammatory and anti-nociceptive activities. MEFF (50, 100 mg/kg/d, p.o.) reduced acute paw edema induced by carrageenin in rats, and showed MEFF analgesic activity, as determined by an acetic acid-induced writhing test and a hot plate test in mice. To investigate the mechanism of the anti-inflammatory action of MEFF, we examined the effect of MEFF on lipopolysaccharide (LPS)-induced responses in murine macrophages cell line RAW 264.7. MEFF potently inhibited the production of nitric oxide (NO), prostaglandin E₂ (PGE₂), and tumor necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages. Consistent with these observations, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) levels were reduced by MEFF in a dose-dependent manner. Furthermore, MEFF suppressed nuclear factor-кB (NF-кB) activation in LPS-stimulated RAW 264.7 macrophages. These findings suggest that the anti-inflammatory and anti-nociceptive properties of the methanol extract of MEFF may result from the inhibition of iNOS and COX-2 expression through the down-regulation of NF-кB binding activity.
Park, Hee-Juhn,Kwon, Sang-Hyuk,Lee, Joo-Han,Lee, Kyou-Heung,Miyamoto, Ken-ichi,Lee, Kyung-Tae 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Hederagenin, δ-hederin {hederagenin α_-L-arabinoside}, kalopanax-saponin A (hederagenin 3-O-α_-L-rhamnosyl(1→2) -α_-L-arabinoside}, kalopanaxaponin I {hederagenin 3-O-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-L-arabinoside}, and sapindoside C {hederagenin 3-O-β-_D-glucosyl(1→4)-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-_L-arabinoside} were isolated from stem bark of Kalopanax pictus Nakai (Araliaceae). Among glycosides of hederagenin, disaccharide (kalopanaxaponin A, commonly also called α-hederin), trisaccharide (kalopanaxaponin l), and tetrasaccharide (sapindoside C) showed significant cytotoxicity on several types of tumor cells, while hederagenin itself exhibited only weak cytotoxicity and its monosaccharide (δ-hederin) was non-cytotoxic. From these results, it suggests that the arabinosyl moiety at C-3 blocks the activity of hederagenin and the position of the second sugar for glycoside linkage is also important for cytotoxicity. In the in vivo experiments, kalopanaxsaponin A (15 mg/kg, i.p.) apparently increased the life span of mice bearing Colon 26 and 3LL Lewis lang carcinoma, as well as cisplatin (3 mg/kg, i.p.). These results indicated that kalopanaxsaponin A has potential anti-tumor applications.
Hee Juhn Park,Sang Hyuk Kwon,Ki Oug Yoo,Won Tae Jung,Kyung Tae Lee,Joo Il Kim,Yong Nam Han 한국생약학회 2000 Natural Product Sciences Vol.6 No.2
Two known eudesmanolides, magnolialide and artesin, were isolated from the roots of Cichorium intybus. Their structures were confirmed by HMBC and NOESY NMR spectral interpretation. Therefore, guaianolides and eudesmanolides that have been previously reported should be revised.
Flavonol Glycosides from the Leaves of Machilus thunbergii
Park, Jong Cheol,Young, Han Suk,Park, Hee Juhn,Park, Soon Chul 순천대학교 기초과학연구소 1990 基礎科學硏究誌 Vol.1 No.-
From the leaves of Machilus thunbergii Sieb. Et Zucc. (Lauraceae) afzelin, guaiyaverin and rutin were isolated and identified by chemical and spectral analysis.
Hee-Juhn Park,Hyun-Ju Jung,이경태,Jongwon Choi 한국생약학회 2006 Natural Product Sciences Vol.12 No.4
for the cytotoxicity from plant origin is the first stage for anti-cancer drug development. Avariety of terpenoids with exomethylene, epoxide, allyl, α,β-unsaturated carbonyl, acetylenes, and α-methylene-γ-pathways. These are found among monoterpenes, sesquiterpenes, triterpenes, flavonoids, coumarins, diarylhep-tanoids, and even organosulfuric compounds. The most essential characteristics of natural cytotoxic substances isto possess the strong electrophilicity that is susceptible to nucleophilic biomolecules in the cell. Thiol-reductantsand superoxide dismutase can block or delay apoptosis. Thus, ROS and the resulting cellular redox-potentialchanges can be parts of the signal transduction pathway during apoptosis. Disturbance of the balance of oxi-Saponins with the cytotoxicity are restricted to their monodesmosides, rather than to bisdesmosides. Thosesaponins exhibited calcium ion-mediated apoptosis in addition to cytotoxicity whereas they showed alsodifferentiation without extracellular calcium ion. The properties on cytotoxicity, apoptosis, and differentiationwere assumed to depend on resultant oxidative stress to the cells. In this review, we describe a spectrum ofcytotoxic compounds with various action mechanisms.Keywordscytotoxicity, natural products, apoptosis, differentiation, reactive oxygen species (ROS), oxidativestress
Hee-Juhn Park,최재수,성수휘,송병민,박경식,박희준 한국생약학회 2018 Natural Product Sciences Vol.24 No.4
The three flavone glycosides, 4'-O-methylisoscutellarein 7-O-(6'''-O-acetyl)-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (1), isoscutellarein 7-O-(6'''-O-acetyl)-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (3), and isoscutellarein 7-O-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-b-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC50s, 39.94 mg/ml for AChE and 86.98 mg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.
Chemical Study on the Leaf of Prunus davidiana
Park, Jong-Hee,Kim, Jin-Soo,Lee, Jun-Do,Park, Hee-Juhn 한국자원식물학회 1997 한국자원식물학회지 Vol.10 No.1
우리나라 민간약으로서 신경통 및 류마치스의 치료에 널리 사용되고 있는 산복사나무(Prunus davidiana)의 잎으로부터 naringenin 및 그 배당체, kaempferol 및 그 배당체, kaempferide glueoside, quercetin glucoside 및 d-catechin을 단리하였다. From the leaf of Prunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, kaempferide glucoside, quercetin glucoside and d-catechin were isolated.