Antiplatelet, anticoagulant, and profibrinolytic activities of cudratricusxanthone A

Yoo, Hayoung,Ku, Sae-Kwang,Lee, Wonhwa,Kwak, Soyoung,Baek, Young-Doo,Min, Byung-Woon,Jeong, Gil-Saeng,Bae, Jong-Sup 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8

Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudrania tricuspidata Bureau, is known to possess hepatoprotective, antiproliferative and anti-inflammatory activities. However, antiplatelet, anticoagulant, and profibrinolytic properties have not been studied. The anticoagulant activities of CTXA were measured by monitoring activated partial thromboplastin-time (aPTT), prothrombin time (PT), and the activities of cell-based thrombin and activated factor X (FXa). The effects of CTXA on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were also tested in tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ activated human umbilical vein endothelial cells. Our data showed that CTXA inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation, prolonged aPTT and PT significantly and inhibited the activities and production of thrombin and FXa. CTXA prolonged in vivo bleeding time and inhibited $TNF-{\alpha}$ induced PAI-1 production. Furthermore, PAI-1/t-PA ratio was significantly decreased by CTXA. Collectively, these results indicate that CTXA possesses antithrombotic activities and suggest that the current study could provide bases for the development of new anticoagulant agents.

Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo

Yoo, Hayoung,Ku, Sae-Kwang,Baek, Young-Doo,Bae, Jong-Sup Springer-Verlag 2014 Inflammation research Vol.63 No.3

The Study on Relationship Between Heterophoria Tendency and Asthenopia in College Students in Jeonbuk Area

Hyunjin Oh,Hayoung Doo 중소기업정보기술융합학회 2014 중소기업융합학회 국제학술대회논문집 Vol.1 No.1

Continuous Meter-Scale Synthesis of Weavable Tunicate Cellulose/Carbon Nanotube Fibers for High-Performance Wearable Sensors

Cho, Soo-Yeon,Yu, Hayoung,Choi, Junghoon,Kang, Hohyung,Park, Seoungwoong,Jang, Ji-Soo,Hong, Hye-Jin,Kim, Il-Doo,Lee, Seoung-Ki,Jeong, Hyeon Su,Jung, Hee-Tae American Chemical Society 2019 ACS NANO Vol.13 No.8

<P>Weavable sensing fibers with superior mechanical strength and sensing functionality are crucial for the realization of wearable textile sensors. However, in the fabrication of previously reported wearable sensing fibers, additional processes such as reduction, doping, and coating were essential to satisfy both requirements. The sensing fibers should be continuously synthesized in a scalable process for commercial applications with high reliability and productivity, which was challenging. In this study, we first synthesize mass-producible wearable sensing fibers with good mechanical properties and sensing functionality without additional processes by incorporating carbon nanotubes (CNTs) into distinct nanocellulose. Nanocellulose extracted from tunicate (TCNF) is homogeneously composited with single-walled CNTs, and composite fibers (TCNF/CNT) are continuously produced in aligned directions by wet spinning, facilitating liquid-crystal properties. The TCNF/CNT fibers exhibit a superior gas (NO<SUB>2</SUB>)-sensing performance with high selectivity and sensitivity (parts-per-billion detection). In addition, the TCNF/CNT fibers can endure complex and harsh distortions maintaining their intrinsic sensing properties and can be perfectly integrated with conventional fabrics using a direct weaving process. Our meter-scale scalable synthesis of functional composite fibers is expected to provide a mass production platform of versatile wearable sensors.</P> [FIG OMISSION]</BR>

Heterogeneous Metal Oxide-Graphene Thorn-Bush Single Fiber as a Freestanding Chemiresistor

Jang, Ji-Soo,Yu, Hayoung,Choi, Seon-Jin,Koo, Won-Tae,Lee, Jiyoung,Kim, Dong-Ha,Kang, Joon-Young,Jeong, Yong Jin,Jeong, Hyeonsu,Kim, Il-Doo American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.10

<P>The development of freestanding fiber-type chemiresistors, having high integration ability with various portable electronics including smart clothing systems, is highly demanding for the next-generation wearable sensing platforms. However, critical challenges stemming from the irreversible chemical sensing kinetics and weak reliability of the freestanding fiber-type chemiresistor hinder their practical use. In this work, for the first time, we report on the potential suitability of the freestanding and ultraporous reduced graphene oxide fiber functionalized with WO<SUB>3</SUB> nanorods (porous WO<SUB>3</SUB> NRs-RGO composite fiber) as a sensitive nitrogen dioxide (NO<SUB>2</SUB>) detector. By employing a tunicate cellulose nanofiber (TCNF), which is a unique animal-type cellulose, the numerous mesopores are formed on a wet-spun TCNF-GO composite fiber, unlike a bare GO fiber with dense surface structure. More interestingly, due to the superior wettability of TCNF, the aqueous tungsten precursor is uniformly adsorbed on an ultraporous TCNF-GO fiber, and subsequent heat treatment results in the thermal reduction of a TCNF-GO fiber and hierarchical growth of WO<SUB>3</SUB> NRs perpendicular to the porous RGO fiber (porous WO<SUB>3</SUB> NRs-RGO fiber). The freestanding porous WO<SUB>3</SUB> NRs-RGO fiber shows a notable response to 1 ppm NO<SUB>2</SUB>. Furthermore, we successfully demonstrate reversible NO<SUB>2</SUB> sensing characteristics of the porous WO<SUB>3</SUB> NRs-RGO fiber, which is integrated on a wrist-type wearable sensing device.</P> [FIG OMISSION]</BR>

All-carbon fiber-based chemical sensor: Improved reversible NO₂ reaction kinetics

Choi, Seon-Jin,Lee, Dong-Myeong,Yu, Hayoung,Jang, Ji-Soo,Kim, Min-Hyeok,Kang, Joon-Young,Jeong, Hyeon Su,Kim, Il-Doo Elsevier 2019 Sensors and actuators. B Chemical Vol.290 No.-

<P><B>Abstract</B></P> <P>All-carbon fiber-based chemiresistor is fabricated by assembling reduced graphene oxide (RGO) fiber and carbon nanotube (CNT) fiber as reversible NO<SUB>2</SUB> sensing layer and flexible heater, respectively. Both graphene oxide (GO) and CNT fibers were synthesized by wet-spinning technique facilitating lyotropic nematic liquid crystal (LC) property. Randomly entangled CNT fiber-based heater, which is embedded in one surface of colorless polyimide (cPI) film with thickness of ˜200 μm, exhibits high bending stability and heating property up to 100 °C. Single reduced graphene oxide (RGO) fiber obtained after heat treatment at 900 °C in H<SUB>2</SUB>/N<SUB>2</SUB> ambient was integrated on the CNT fiber-embedded cPI heater, thereby establishing a new type of all-carbon fiber sensing platform. As a result, accelerated NO<SUB>2</SUB> adsorption and desorption kinetics were achieved with RGO fiber at an elevated temperature. In particular, a 9.22-fold enhancement in desorption kinetic (<I>k</I> <SUB>des</SUB> = 8.85 × 10<SUP>–3</SUP> s<SUP>–1</SUP>) was observed at 100 °C compared with the desorption kinetic (<I>k</I> <SUB>des</SUB> = 0.96 × 10<SUP>–3</SUP> s<SUP>–1</SUP>) at 50 °C, which was attributed to the effective heating by CNT fiber networks. This work pioneered a research on the use of emerging carbonaceous fibers for potential application in wearable chemical detectors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel all-carbon fiber-based NO<SUB>2</SUB> sensor was fabricated for reliable environmental monitoring. Both RGO fiber and CNT fiber were synthesized by wet-spinning process, which is facile and compatible with large-scale production. </LI> <LI> Unique sensing architectures of 1D graphene fiber were achieved with nitrogen doping for NO<SUB>2</SUB> sensors. Highly conductive nitrogen-doped reduced graphene oxide (RGO) fiber was achieved with wrinkled surface morphology. </LI> <LI> CNT fibers were firstly demonstrated as heating networks for reversible NO<SUB>2</SUB> reaction. The CNT fibers with high electrical conductivity and mechanical stability are suitable for heating element to control the operating temperature of sensor. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Selective Laser Melting Process for Sensor Embedding into SUS316L with Heat Dissipative Inner Cavity Design

Min Sik Lee,Hayeol Kim,Young Tak Koo,Ji‑Hun Yu,Hayoung Chung,Namhun Kim,Hyokyung Sung,Im Doo Jung 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.1

Artifcial intelligence and Internet of Things (IoT) technology, which are the core of the 4th industrial revolution, can resolvemany problems that optimization of production times in the manufacturing process and reduction of materials required etc. In order to utilize the 4th industrial revolution technology, real-time monitoring technology of metal parts is essential, sotechnology for embedding sensors and IC chips into parts is essential. Using metal 3d printing technology, it is possible toembed IC chips into metal parts, which was impossible because of the existing high-temperature metal manufacturing processof casting or forging. Here we introduce a novel new method for sensor embedding into SUS316L by hemisphere design toavoid direct laser exposure onto sensors during selective laser melting process. Thermal and microstructural analysis wascarried out to characterize the property of inner hemisphere for safe thermal couple embedding into SUS316L.