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RISS 인기검색어
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- 저자 : Hassan Niknejad (검색결과 3 건)
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Fatemeh Mazini,Mohammad-Amin Abdollahifar,Hassan Niknejad,Asma Manzari-Tavakoli,Mohsen Zhaleh,Reza Asadi-Golshan,Ali Ghanbari The Korean Society for Reproductive Medicine 2023 Clinical and Experimental Reproductive Medicine Vol.50 No.4
Objective: High temperatures can trigger cellular oxidative stress and disrupt spermatogenesis, potentially leading to male infertility. We investigated the effects of retinoic acid (RA), chitosan nanoparticles (CHNPs), and retinoic acid loaded with chitosan nanoparticles (RACHNPs) on spermatogenesis in mice induced by scrotal hyperthermia (Hyp). Methods: Thirty mice (weighing 25 to 30 g) were divided into five experimental groups of six mice each. The groups were as follows: control, Hyp induced by a water bath (43 ℃C for 30 minutes/day for 5 weeks), Hyp+RA (2 mg/kg/day), Hyp+CHNPs (2 mg/kg/72 hours), and Hyp+RACHNPs (4 mg/kg/72 hours). The mice were treated for 35 days. After the experimental treatments, the animals were euthanized. Sperm samples were collected for analysis of sperm parameters, and blood serum was isolated for testosterone measurement. Testis samples were also collected for histopathology assessment, reactive oxygen species (ROS) evaluation, and RNA extraction, which was done to compare the expression levels of the bax, bcl2, p53, Fas, and FasL genes among groups. Additionally, immunohistochemical staining was performed. Results: Treatment with RACHNPs significantly increased stereological parameters such as testicular volume, seminiferous tubule length, and testicular cell count. Additionally, it increased testosterone concentration and improved sperm parameters. We observed significant decreases in ROS production and caspase-3 immunostaining in the RACHNP group. Moreover, the expression levels of bax, p53, Fas, and FasL significantly decreased in the groups treated with RACHNPs and RA. Conclusion: RACHNPs can be considered a potent antioxidative and antiapoptotic agent for therapeutic strategies in reproductive and regenerative medicine.
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Aeroelastic analysis of cantilever non-symmetric FG sandwich plates under yawed supersonic flow
Mohammad Hosseini,Ali Ghorbanpour Arani,Mohammad Reza Karamizadeh,Hassan Afshari,Shahriar Niknejad 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.6
In this paper, a numerical solution is presented for supersonic flutter analysis of cantilever non-symmetric functionally graded (FG) sandwich plates. The plate is considered to be composed of two different functionally graded face sheets and an isotropic homogeneous core made of ceramic. Based on the first order shear deformation theory (FSDT) and linear piston theory, the set of governing equations and boundary conditions are derived. Dimensionless form of the governing equations and boundary conditions are derived and solved numerically using generalized differential quadrature method (GDQM) and critical velocity and flutter frequencies are calculated. For various values of the yaw angle, effect of different parameters like aspect ratio, thickness of the plate, power law indices and thickness of the core on the flutter boundaries are investigated. Numerical examples show that wings and tail fins with larger length and shorter width are more stable in supersonic flights. It is concluded for FG sandwich plates made of Al-Al2O3 that increase in volume fraction of ceramic (Al2O3) increases aeroelastic stability of the plate. Presented study confirms that improvement of aeroelastic behavior and weight of wings and tail fins of aircrafts are not consistent items. It is shown that value of the critical yaw angle depends on aspect ratio of the plate and other parameters including thickness and variation of properties have no considerable effect on it. Results of this paper can be used in design and analysis of wing and tail fin of supersonic airplanes.
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Mohammadreza Kasravi,Armin Ahmadi,Amirhesam Babajani,Radman Mazloomnejad,Mohammad Reza Hatamnejad,Siavash Shariatzadeh,Soheyl Bahrami,Hassan Niknejad 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to address the donor shortage as well as immunologic rejection attributed to cells in conventional tissue/organ transplantation. Decellularization, as the key process in manufacturing ECM scaffolds, removes immunogen cell materials and significantly alleviates the immunogenicity and biocompatibility of derived scaffolds. However, the application of these bioscaffolds still confronts major immunologic challenges. This review discusses the interplay between damage-associated molecular patterns (DAMPs) and antigens as the main inducers of innate and adaptive immunity to aid in manufacturing biocompatible grafts with desirable immunogenicity. It also appraises the impact of various decellularization methodologies (i.e., apoptosis-assisted techniques) on provoking immune responses that participate in rejecting allogenic and xenogeneic decellularized scaffolds. In addition, the key research findings regarding the contribution of ECM alterations, cytotoxicity issues, graft sourcing, and implantation site to the immunogenicity of decellularized tissues/organs are comprehensively considered. Finally, it discusses practical solutions to overcome immunogenicity, including antigen masking by crosslinking, sterilization optimization, and antigen removal techniques such as selective antigen removal and sequential antigen solubilization.
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