Chronotopic Realignments and the Shifting Semiotics and Politics of Visibility in Brazilian Candomblé Activism

Elina I. Hartikainen 한국외국어대학교 HK 세미오시스 연구센터 2017 Signs and Society Vol.5 No.2

This article examines the shifting semiotics and politics of visibility in Brazilian Candomblé activism in the late 2000s in the city of Salvador. It analyses how the use of publicly salient discourses and signs of peace and antiviolence activism by activists from the African diasporic religion Candomblé reconfigured the religion’s practitioners public image from that of politically passive practitioners of “black magic” and self-sacrificing “black mothers” to that of politically active peace and antiviolence activists. I argue that this transformation was effected by a realignment of the general public’s chronotopic orientation toward the religion and its practitioners from a chronotope of concealment to one of political visibility. This shift in chronotopic orientation not only aligned Candomblé practitioners with the social persona of the politically engaged peace activist but also produced a new social persona of a religiously motivated “black mother of peace.”

Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine

( Jonna Jalanka ),( Ching Lam ),( Andrew Bennett ),( Anna Hartikainen ),( Fiona Crispie ),( Laura A Finnegan ),( Paul D Cotter ),( Robin Spiller ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in IBS-D. Methods We studied a subset of patients (n = 43) from a previously published 12-week radomized placebo-controlled trial of mesalazine. Mucosal biopsies were assessed by immunohistochemistry and reverse transcription-polymerase chain reaction for a range of markers of inflammation, altered permeability, and sensory receptors including Toll-like receptors (TLRs) at randomization after treatment. All biopsy data were compared to 21 healthy controls. Patient’s stool microbiota composition was analysed through 16S ribosomal RNA sequencing. Results We found no evidence of increased immune activation compared to healthy controls. However, we did find increased expression of receptors in both sensory pathways and innate immune response including TLR4. Higher TLR4 expression was associated with greater urgency. TLR4 expression correlated strongly with the expression of the receptors bradykinin receptor B2, chemerin chemokine-like receptor 1, and transient receptor potential cation channel, subfamily A, member 1 as well as TLR4’s downstream adaptor myeloid differentiation factor 88. Mesalazine had minimal effect on either gene expression or microbiota composition. Conclusions Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inflammatory bowel diseases is likely secondary to reduced inflammation. Increased expression of TLR4 and correlated receptors in IBS may mediate a general increase in sensitivity to external stimuli, particularly those that signal via the TLR system. (J Neurogastroenterol Motil 2021;27:279-291)

Testing of Common Electromagnetic Environments for Risk of Interference with Cardiac Pacemaker Function

Tiikkaja, Maria,Aro, Aapo L.,Alanko, Tommi,Lindholm, Harri,Sistonen, Heli,Hartikainen, Juha E.K.,Toivonen, Lauri,Juutilainen, Jukka,Hietanen, Maila Occupational Safety and Health Research Institute 2013 Safety and health at work Vol.4 No.3

Background: Cardiac pacemakers are known to be susceptible to strong electromagnetic fields (EMFs). This in vivo study investigated occurrence of electromagnetic interference with pacemakers caused by common environmental sources of EMFs. Methods: Eleven volunteers with a pacemaker were exposed to EMFs produced by two mobile phone base stations, an electrically powered commuter train, and an overhead high voltage transmission lines. All the pacemakers were programmed in normal clinically selected settings with bipolar sensing and pacing configurations. Results: None of the pacemakers experienced interference in any of these exposure situations. However, often it is not clear whether or not strong EMFs exist in various work environments, and hence an individual risk assessment is needed. Conclusions: Modern pacemakers are well shielded against external EMFs, and workers with a pacemaker can most often return to their previous work after having a pacemaker implanted. However, an appropriate risk assessment is still necessary after the implantation of a pacemaker, a change of its generator, or major modification of its programming settings.

Testing of Common Electromagnetic Environments for Risk of Interference with Cardiac Pacemaker Function

Maria Tiikkaja,Aapo L. Aro,Tommi Alanko,Harri Lindholm,Heli Sistonen,Juha E.K. Hartikainen,Lauri Toivonen,Jukka Juutilainen,Maila Hietanen 한국산업안전보건공단 산업안전보건연구원 2013 Safety and health at work Vol.4 No.3

Background: Cardiac pacemakers are known to be susceptible to strong electromagnetic fields (EMFs). This in vivo study investigated occurrence of electromagnetic interference with pacemakers caused by common environmental sources of EMFs. Methods: Eleven volunteers with a pacemaker were exposed to EMFs produced by two mobile phone base stations, an electrically powered commuter train, and an overhead high voltage transmission lines. All the pacemakers were programmed in normal clinically selected settings with bipolar sensing and pacing configurations. Results: None of the pacemakers experienced interference in any of these exposure situations. However, often it is not clear whether or not strong EMFs exist in various work environments, and hence an individual risk assessment is needed. Conclusions: Modern pacemakers are well shielded against external EMFs, and workers with a pacemaker can most often return to their previous work after having a pacemaker implanted. However, an appropriate risk assessment is still necessary after the implantation of a pacemaker, a change of its generator, or major modification of its programming settings.

Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study

Tolppanen, Anna-Maija,Ahonen, Riitta,Koponen, Marjaana,Lavikainen, Piia,Purhonen, Maija,Taipale, Heidi,Tanskanen, Antti,Tiihonen, Jari,Tiihonen, Miia,Hartikainen, Sirpa The Korean Society for Preventive Medicine 2016 Journal of Preventive Medicine and Public Health Vol.49 No.2

Objectives: Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer's disease (AD) have been inconsistent. We investigated whether the month or season of birth are associated with AD. Methods: A nationwide nested case-control study including all community-dwellers with clinically verified AD diagnosed in 2005 to 2012 (n=70 719) and up to four age- sex- and region of residence-matched controls (n=282 862) residing in Finland. Associations between month and season of birth and AD were studied with conditional logistic regression. Results: Month of birth was not associated with AD (p=0.09). No strong associations were observed with season (p=0.13), although in comparison to winter births (December-February) summer births (June-August) were associated with higher odds of AD (odds ratio, 1.03; 95% confidence interval, 1.00 to 1.05). However, the absolute difference in prevalence in winter births was only 0.5% (prevalence of those born in winter were 31.7% and 32.2% for cases and controls, respectively). Conclusions: Although our findings do not support the hypothesis that season of birth is related to AD/dementia risk, they do not invalidate the developmental origins of health and disease hypothesis in late-life cognition. It is possible that season does not adequately capture the early life circumstances, or that other (postnatal) risk factors such as lifestyle or socioeconomic factors overrule the impact of prenatal and perinatal factors.

Month and Season of Birth as a Risk Factor for Alzheimer’s Disease: A Nationwide Nested Case-control Study

Anna-Maija Tolppanen,Riitta Ahonen,Marjaana Koponen,Piia Lavikainen,Maija Purhonen,Heidi Taipale,Antti Tanskanen,Jari Tiihonen,Miia Tiihonen,Sirpa Hartikainen 대한예방의학회 2016 Journal of Preventive Medicine and Public Health Vol.49 No.2

Objectives: Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We investigated whether the month or season of birth are associated with AD. Methods: A nationwide nested case-control study including all community-dwellers with clinically verified AD diagnosed in 2005 to 2012 (n=70 719) and up to four age- sex- and region of residence-matched controls (n=282 862) residing in Finland. Associations between month and season of birth and AD were studied with conditional logistic regression. Results: Month of birth was not associated with AD (p=0.09). No strong associations were observed with season (p=0.13), although in comparison to winter births (December-February) summer births (June-August) were associated with higher odds of AD (odds ratio, 1.03; 95% confidence interval, 1.00 to 1.05). However, the absolute difference in prevalence in winter births was only 0.5% (prevalence of those born in winter were 31.7% and 32.2% for cases and controls, respectively). Conclusions: Although our findings do not support the hypothesis that season of birth is related to AD/dementia risk, they do not invalidate the developmental origins of health and disease hypothesis in late-life cognition. It is possible that season does not adequately capture the early life circumstances, or that other (postnatal) risk factors such as lifestyle or socioeconomic factors overrule the impact of prenatal and perinatal factors.