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Marion Piechotta,Lars Holzhausen,Marcelo Gil Araujo,Maike Heppelmann,Anja Sipka,Chistiane Pfarrer,Hans-Joachim Schuberth,Heinrich Bollwein 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.3
Cows with different Insulin-like Growth Factor-I (IGF-I)concentrations showed comparable expression levels of hepaticgrowth hormone receptor (GHR). Suppressor of cytokinesignaling 2 (SOCS2), could be responsible for additionalinhibition of the GHR signal cascade. The aims were to monitorcows with high or low antepartal IGF-I concentrations(IGF-Ihigh or IGF-Ilow), evaluate the interrelationships ofendocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to 254 days after artificialinsemination (AI)). Blood samples were drawn daily (day −17until calving) and IGF-I, GH, insulin, thyroid hormones,estradiol, and progesterone concentrations were measured. Liver biopsies were taken (day 264 ± 1 after AI and postpartum)to measure mRNA expression (IGF-I, IGFBP-2, IGFBP-3,IGFBP-4, acid labile subunit (ALS), SOCS2, deiodinase1,GHR1A). IGF-I concentrations in the two groups were different(p < 0.0001). However, GH concentrations and GHR1A mRNAexpression were comparable (p > 0.05). Thyroxine levels andALS expression were higher in the IGF-Ihigh cows compared toIGF-Ilow cows. Estradiol concentration tended to be greater inthe IGF-Ilow group (p = 0.06). It was hypothesized that low IGF-Ilevels are associated with enhanced SOCS2 expression althoughthis could not be decisively confirmed by the present study.
Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy
Marie M Meyerholz,Kirsten Mense,Michael Lietzau,Ana Kassens,Matthias Linden,Hendrike Knaack,Elisa Wirthgen,Andreas Hoeflich,Mariam Raliou,Christophe Richard,Olivier Sandra,Hans-Joachim Schuberth,Marti 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4
This study was conducted to determine if the main components of the somatotropic axis change during the early phase of pregnancy in the maternal blood system and whether differences exist on day 18 after pregnancy recognition by the maternal organism. Blood samples of pregnant heifers (Holstein Friesian; n = 10 after embryo transfer) were obtained on the day of ovulation (day 0), as well as on days 7, 14, 16 and 18 and during pregnant, non-pregnant and negative control cycles. The concentrations of progesterone (P4), oestrogen, growth hormone (GH), insulin-like growth factor-1 and -2 (IGF1, -2) and IGF-binding protein-2, -3 and -4 (IGFBP2, -3, -4) were measured. The mRNA expressions of growth hormone receptor 1A, IGF1, IGF2, IGFBP2, IGFBP3 and IGFBP4 were detected using RT-qPCR in liver biopsy specimens (day 18). In all groups, total serum IGF1 decreased from day 0 to 16. Notably, IGFBP4 maternal blood concentrations were lower during pregnancy than during non-pregnant cycles and synchronized control cycles. It can be speculated that the lower IGFBP4 in maternal blood may result in an increase of free IGF1 for local action. Further studies regarding IGFBP4 concentration and healthy early pregnancy are warranted.