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RISS 인기검색어
- 검색키워드
- 저자 : Hans Link (검색결과 3 건)
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Yu-Min Huang-Link,Mats Fredrikson,Hans Link 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.3
Background and Purpose It is exceedingly difcult to diferentiate benign multiple sclerosis (BMS) from relapsing-remitting multiple sclerosis (RRMS) based on clinical characteristics, neuroimaging, and cerebrospinal fuid tests. Optical coherence tomography (OCT) allows quantifcation of retinal structures, such as the retinal nerve fber layer (RNFL) thickness, at the optic disc and the ganglion cell layer (GCL) at the macula, on a micrometer scale. It can also be used to trace minor alterations and the progression of neurodegeneration, help predict BMS, and infuence the choice of therapy. To utilize OCT to detect the extent of changes of the optic disk and macular microstructure in patients with BMS and RRMS compared to healthy controls (HCs), with special focus on changes related to the presence/absence of optic neuritis (ON). Methods Spectral-domain OCT was applied to examine eyes from 36 patients with multiple sclerosis (MS), comprising 11 with BMS and 25 with RRMS, and 34 HCs. Results Te RNFL and GCL were signifcantly thinner in eyes previously afected by ON, irrespective of the type of MS (i.e., BMS or RRMS), than in HCs. Signifcant thinning of the GCL was also observed in non-ON RRMS (and not non-ON BMS) compared to HCs. Correspondingly, a signifcant association between disease duration and thinning rates of the RNFL and GCL was observed only in non-ON RRMS (-0.54±0.24 and -0.43±0.21 μm/year, mean± SE; p<0.05 for both), and not in non-ON BMS (-0.11±0.27 and -0.24±0.24 μm/year). Conclusions Te RNFL and GCL were thinner in both ON- and non-ON MS, but the change was more pronounced in ON MS, irrespective of the MS subtype studied herein. GCL thinning and the thinning rate of both the GCL and RNFL were less pronounced in non-ON BMS than in non-ON RRMS. Tese fndings may help to predict the course of BMS.
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Proton and Helium Spectra from the CREAM-III Flight
Yoon, Y. S.,Anderson, T.,Barrau, A.,Conklin, N. B.,Coutu, S.,Derome, L.,Han, J. H.,Jeon, J. A.,Kim, K. C.,Kim, M. H.,Lee, H. Y.,Lee, J.,Lee, M. H.,Lee, S. E.,Link, J. T.,Menchaca-Rocha, A.,Mitchell, J American Astronomical Society 2017 The Astrophysical journal Vol.839 No.1
<P>Primary cosmic-ray elemental spectra have been measured with the balloon-borne Cosmic Ray Energetics And Mass (CREAM) experiment since 2004. The third CREAM payload (CREAM-III) flew for 29 days during the 2007-2008 Antarctic season. Energies of incident particles above 1 TeV are measured with a calorimeter. Individual elements are clearly separated with a charge resolution of similar to 0.12 e (in charge units) and similar to 0.14 e for protons and helium nuclei, respectively, using two layers of silicon charge detectors. The measured proton and helium energy spectra at the top of the atmosphere are harder than other existing measurements at a few tens of GeV. The relative abundance of protons to helium nuclei is 9.53 +/- 0.03 for the range of 1 TeV/n. to 63 TeV/n. This ratio is considerably smaller than other measurements at a few tens of GeV/n. The spectra become softer above similar to 20 TeV. However, our statistical uncertainties are large at these energies and more data are needed.</P>
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Performances of photodiode detectors for top and bottom counting detectors of ISS-CREAM experiment
Hyun, H.J.,Anderson, T.,Angelaszek, D.,Baek, S.J.,Copley, M.,Coutu, S.,Han, J.H.,Huh, H.G.,Hwang, Y.S.,Im, S.,Jeon, H.B.,Kah, D.H.,Kang, K.H.,Kim, H.J.,Kim, K.C.,Kwashnak, K.,Lee, J.,Lee, M.H.,Link, J Elsevier 2015 Nuclear Instruments & Methods in Physics Research. Vol.787 No.-
<P><B>Abstract</B></P> <P>The Cosmic Ray Energetics and Mass (CREAM) experiment at the International Space Station (ISS) aims to elucidate the source and acceleration mechanisms of high-energy cosmic rays by measuring the energy spectra from protons to iron. The instrument is planned for launch in 2015 at the ISS, and it comprises a silicon charge detector, a carbon target, top and bottom counting detectors, a calorimeter, and a boronated scintillator detector. The top and bottom counting detectors are developed for separating the electrons from the protons, and each of them comprises a plastic scintillator and a 20×20 silicon photodiode array. Each photodiode is 2.3cm×2.3cm in size and exhibits good electrical characteristics. The leakage current is measured to be less than 20nA/cm<SUP>2</SUP> at an operating voltage. The signal-to-noise ratio is measured to be better than 70 using commercial electronics, and the radiation hardness is tested using a proton beam. A signal from the photodiode is amplified by VLSI (very-large-scale integration) charge amp/hold circuits, the VA-TA viking chip. Environmental tests are performed using whole assembled photodiode detectors of a flight version. Herein, we present the characteristics of the developed photodiode along with the results of the environmental tests.</P>
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