http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
논문 : 한옥 생산성 향상을 위한 설계지원 방안에 관한 연구 실무 -부재가공 프로세스 분석을 중심으로-
이현우 ( Hyun Woo Lee ),정성원 ( Sung Won Jung ),전한종 ( Han Jong Jun ) 디자인융복합학회 2012 디자인융복합연구 Vol.11 No.5
기존 한옥의 계승을 위한 관련 연구가 진행되고 있으나, 한옥 보급에는 실용성을 띄지 못하고 있다. 이는 한옥 시공기술의 복잡성과 자재 생산기술 부족으로 인한 제한적 범위 내에서 공사가 진행됨에 따라 높은 공사비를 원인으로 꼽을 수 있다. 이에 따라 현재 전통 한옥이 가진 정체성을 살리고 현시대에 보급될 수 있는 신 한옥으로의 진화를 위해 부재간의 연관을 분석하고 조립하는 방식을 지식으로 구성하고 디지털 모델링을 함으로써 공사비 절감이 가능케 하는 방법 등이 연구되고 있다. 본 연구에서는 한옥 설계자를 고려한 효율적인 부재 가공 정보 지원을 목표로 한옥 부재 실무 가공 분석을 통해 경제성, 시공성을 파악하고 최적화 방안을 위한 한옥 부재 제작 CNC 시뮬레이션을 통해 효율적인 가공 프로세스의 발전 가능성을 예측하여 최적화된 부재가공 정보를 제안하고 이를 기반으로 한옥 수요자들을 위한 설계지원 방법에 대한 구체적인 방안을 제시함으로써 한옥의 생상성 향상에 기여하고자 한다. There have been a lot of studies about the Han-ok, the Korean-style house, in perspective of the inheritage of existing ones, but there are no practicality in the supply of Han-ok. The cause is considered to exist in the complexity of Han-ok and the techniques required to manufacture its components and in the relatively higher construction expenses in the process which is within restricted range. On the contrary, in order to preserve the identity of traditional Han-ok and encourage the evolution to create a new Han-ok that can be supplied to the present period, there has been studies that analyzes the connection between sub-components and assemble them into a digital model which can possibly decrease the expenses spent on construction. The research`s objective is to provide valuable information for Han-ok designers, which contains methods on manufacturing sub-components effectively. Furthermore, by analyzing the current manufacturing method`s workability and economic feasibility, the research can obtain an optimum alternative for improving Han-ok`s production. Also by using CNC simulation, the possibility of an effective production can be predicted, as well as the information that can lead to the optimum method for an efficient sub-component manufacturing and suggest a specific resolution which can also affect on the improvement of Han-ok productivity.
( Ji Yong Kim ),( Jai Sung Lee ),( Yong Seok Han ),( Jun Hee Lee ),( Inhyu Bae ),( Yeo Min Yoon ),( Sang Mo Kwon ),( Sang Hun Lee ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although H2O2 (200 mM) increased intracellular ROS levels in human MSCs, lycopene (10 μmM) pretreatment suppressed H2O2-induced ROS generation and increased survival. H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
Kim, Ji Yong,Lee, Jai-Sung,Han, Yong-Seok,Lee, Jun Hee,Bae, Inhyu,Yoon, Yeo Min,Kwon, Sang Mo,Lee, Sang Hun The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although $H_2O_2$ ($200{\mu}M$) increased intracellular ROS levels in human MSCs, lycopene ($10{\mu}M$) pretreatment suppressed $H_2O_2$-induced ROS generation and increased survival. $H_2O_2$-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by $H_2O_2$ treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
A Rare Case of Tracheomalacia Associated with Vascular Ring in an Infant
Han Seok Joo,Sung Tae Yon,Lee Kyo Jun,Choi Hong Sik,Shim Yon Hee,Nam Yong Taek The Korean Bronchoesophagological Society 2004 大韓氣管食道科學會誌 Vol.10 No.2
Tracheomalacia can be a life threatening upper air way obstructive disease in an infant and vascular rings can be also a major rare cause of tracheoesophageal obstruction. These two rare entities can be combined in one patient because the vascular ring can cause secondary tracheomalacia during development of fetus. The diagnosis of this combination and adequate surgical correction is occasionally difficult. This is a report of an infant who had not diagnosed tracheomalacia associated with vascular ring until 5 months of age because of the prolonged tracheal intubation. The rigid bronchoscopic examination performed under impression of tracheomalacia revealed a concentric tracheal collapse, an unusual bronchoscopic findings of tracheomalacia, which raised a suspicion of the tracheal compression by vascular rings. The 3-D reconstructive DT aortography clearly demonstrated the double aortic arch. The patient was treated surgically by simple division of the left aortic arch and aortopexy with good result. The vascular ring such as double aortic arch should be considered during the diagnosis of tracheomalacia in infants. If the tracheomalacia is associated with vascular ring, simultaneous surgical correction should be performed.
Han Gyeol Park,김태중,Soon Yong Hwang,Jun Young Kim,Junho Choi,김영동,Sang Hoon Shin,송진동 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.4
We report the complex pseudodielectric function < " > = < "1 > + i < "2 > of an oxide-freeAlSb film for energies from 0.7 to 5.0 eV and temperatures from 300 to 803 K. The 1.5-μm-thick filmwas grown on a (001) GaAs substrate by using molecular beam epitaxy. We maintained the film inan ultrahigh vacuum to prevent oxidation artifacts and used a rotating-compensator ellipsometer toobtain the optical properties. Critical-point (CP) energies were obtained by numerically calculatingsecond energy derivatives of the data. Blue shifts of the CP energies and sharper structures wereobserved with decreasing temperature. The calculated CP energies were fit to a linear equation.
HAN, YONG-SEOK,LEE, JUN HEE,LEE, SANG HUN SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3
<P>Fucoidan, a sulfated polysaccharide, has a variety of biological activities, including anti-cancer, anti-angiogenic and anti-inflammatory effects. However, the underlying mechanisms of fucoidan as an anti-cancer agent remain to be elucidated. The present study examined the anti-cancer effect of fucoidan on HT-29 human colon cancer cells. The cell growth of HT29 cells was significantly decreased following treatment with fucoidan (200 <I>μ</I>g/ml). In addition, fucoidan inhibited the migration of HT-29 cells by decreasing the expression levels of matrix metalloproteinase-2 in a dose-dependent manner (0–200 <I>μ</I>g/ml). The underlying mechanism of these inhibitory effects included the downregulation of phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) by treatment with fucoidan. Furthermore, fucoidan increased the expression of cleaved caspase-3 and decreased cancer sphere formation. The present study suggested that fucoidan exerts an anti-cancer effect on HT-29 human colon cancer cells by downregulating the PI3K-Akt-mTOR signaling pathway. Therefore, fucoidan may be a potential therapeutic reagent against the growth of human colon cancer cells.</P>
Han, Yang-Hee,Jung, Bock-Hyun,Kwon, Jun Sung,Lim, Jaemin The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.5
Tracheal invasion is an uncommon complication of thyroid cancer, but it can cause respiratory failure. A rigid bronchoscope may be used to help relieve airway obstruction, but general anesthesia is usually required. Tracheal balloon dilatation and stent insertion can be performed without general anesthesia, but complete airway obstruction during balloon inflation may be dangerous in some patients. Additionally, placement of the stent adjacent to the vocal cords can be technically challenging. An 86-year-old female patient with tracheal invasion resulting from thyroid cancer was admitted to our hospital because of worsening dyspnea. Due to the patient's refusal of general anesthesia and the interventional radiologist's difficulty in completing endotracheal stenting, we performed endotracheal tube balloon dilatation and argon plasma coagulation. We have successfully treated tracheal obstruction in the patient with thyroid cancer by using endotracheal tube balloon inflation and a flexible bronchoscope without general anesthesia or airway obstruction during balloon inflation.