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Han, Jae Hyun,Kim, Ok-Hee,Lee, Sang Chul,Kim, Kee-Hwan,Park, Jung Hyun,Lee, Jae Im,Lee, Kyung Hee,Hong, Ha-Eun,Seo, Haeyeon,Choi, Ho Joong,Ju, Ji Hyeon,Kim, Say-June MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.24
<P>Tumor necrosis factor-α (TNF-α)-driven inflammatory reaction plays a crucial role in the initiation of liver fibrosis. We herein attempted to design genetically engineered adipose-derived stem cells (ASCs) producing etanercept (a potent TNF-α inhibitor), and to determine the anti-fibrotic potential of the secretome released from the etanercept-synthesizing ASCs (etanercept-secretome). First, we generated the etanercept-synthesizing ASCs by transfecting the ASCs with mini-circle plasmids containing the gene insert encoding for etanercept. We subsequently collected the secretory material released from the etanercept-synthesizing ASCs and determined its anti-fibrotic effects both in vitro (in thioacetamide [TAA]-treated AML12 and LX2 cells) and in vivo (in TAA-treated mice) models of liver fibrosis. We observed that while etanercept-secretome increased the viability of the TAA-treated AML12 hepatocytes (p = 0.021), it significantly decreased the viability of the TAA-treated LX2 HSCs (p = 0.021). In the liver of mice with liver fibrosis, intravenous administration of the etanercept-secretome induced significant reduction in the expression of both fibrosis-related and inflammation-related markers compared to the control group (all Ps < 0.05). The etanercept-secretome group also showed significantly lower serum levels of liver enzymes as well as pro-inflammatory cytokines, such as TNF-α (p = 0.020) and IL-6 (p = 0.021). Histological examination of the liver showed the highest reduction in the degree of fibrosis in the entanercept-secretome group (p = 0.006). Our results suggest that the administration of etanercept-secretome improves liver fibrosis by inhibiting TNF-α-driven inflammation in the mice with liver fibrosis. Thus, blocking TNF-α-driven inflammation at the appropriate stage of liver fibrosis could be an efficient strategy to prevent fibrosis.</P>
Mass treatment of head louse infestation with Sumithrin powder in primary schools in Korea
Han-Il Ree(이한일),Tai-Soon Yong(용태순),Ho-Joon Shin(신호준),Chu-Og Shin(신주옥),In-Yong Lee(이인용),Sung-Ahn Seo(서성아),Jang-Hoon Seo(서장훈),Jae-Kyoung Chang(장재경),Du-Ho Lee(이두호),Kyung-il Im(임경일) 대한기생충학열대의학회 1992 The Korean Journal of Parasitology Vol.30 No.4
Sang-Young Han,Yoon-Jong Lee,Haeng-Im Jung,이성욱,임수정,홍승희,정진숙 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.4
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells, that limits adenoviral gene delivery, can be overcome by using adenovirus complexed with the liposome, Ad-PEGPE [1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[methoxy(poly-ethylene glycol)-2000]. We first confirmed that CT-26 mouse colon cancer cells are deficient in CAR by RT-PCR, and then showed that CT-26 cells infected with Ad-GFP/PEGPE exhibited highly enhanced expression of green fluorescent protein (GFP), compared with those infected with Ad-GFP. GFP expression depends on the dose of liposome and adenovirus. Luciferase expression in livers treated with Ad-luc/PEGPE was about 1,000-fold less than those infected with Ad-luc. In a liver metastasis mouse tumor model developed by intrasplenic injection of CT-26 cells, luciferase expression following i.v. injection of Ad-luc/PEGPE was significantly higher in tumors than in adjacent non-neoplastic liver. Following systemic administration of Ad-GFP/PEGPE, GFP expression increased in tumors more than in adjacent liver while the reverse was true following administration of Ad-GFP. In the latter case, GFP expression was higher in liver than in tumors. This study demonstrates that systemic delivery of PEGPE-adenovirus complex is an effective tool of adenoviral delivery as it overcomes limitation due to CAR deficiency of target cells while reducing hepatic uptake and enhancing adenoviral gene expression in tumors.
Han, Ji Yeon,Im, Won Bin,Kim, Donghyuk,Cheong, Sang Hoon,Lee, Ga-yeon,Jeon, Duk Young The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.12
<P>A new color-tunable Eu<SUP>2+</SUP>-doped sodium aluminium silicate, Na<SUB>2−<I>x</I>−<I>y</I></SUB>Al<SUB>2−<I>x</I></SUB>Si<SUB><I>x</I></SUB>O<SUB>4</SUB>:<I>y</I>Eu<SUP>2+</SUP> (0 ≤<I>x</I>≤ 1), phosphor system was investigated as a novel candidate for phosphor-converted white light-emitting diode (LED) applications and successfully synthesized by wet chemical methods based on the hydrolysis of tetraethyl orthosilicate (TEOS). Different crystal structures and emission spectra were obtained by varying the ratio of Al to Si in the phosphor Na<SUB>2−<I>x</I></SUB>Al<SUB>2−<I>x</I></SUB>Si<SUB><I>x</I></SUB>O<SUB>4</SUB> with <I>x</I> value ranging from 0.25 to 0.55. The Na<SUB>2−<I>x</I>−<I>y</I></SUB>Al<SUB>2−<I>x</I></SUB>Si<SUB><I>x</I></SUB>O<SUB>4</SUB>:<I>y</I>Eu<SUP>2+</SUP> phosphor system emitted a maximum intensity at 470–600 nm when using a 395 nm excitation wavelength, and the emission was strongly affected by the crystal structures determined by the <I>x</I> value. Substitution of Eu<SUP>2+</SUP> affected the center wavelength and emission intensity due to changes in the crystal-field effect, which was strongly dependent on the crystal structure. The LED device exhibited an excellent color-rendering index <I>R</I><SUB>a</SUB> of 93 at a correlated color temperature of 4258 K with CIE color coordinates of (0.3629, 0.3427) under a 20 mA forward-bias current. Based on these results, we are currently evaluating the potential application of Na<SUB>2−<I>x</I>−<I>y</I></SUB>Al<SUB>2−<I>x</I></SUB>Si<SUB><I>x</I></SUB>O<SUB>4</SUB>:<I>y</I>Eu<SUP>2+</SUP> as a white-emitting UV-convertible phosphor.</P> <P>Graphic Abstract</P><P>A new color-tunable Eu<SUP>2+</SUP>-doped sodium aluminium silicate, Na<SUB>2−<I>x</I></SUB>Al<SUB>2−<I>x</I></SUB>Si<SUB><I>x</I></SUB>O<SUB>4</SUB> (0 ≤<I>x</I>≤ 1), phosphor system and dependency of its photoluminescence on the three different crystal structures (<I>x</I> value). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm15501j'> </P>
Sung Ho Lee,Tae-Hoon Kim,Yong-Seog Oh,Seil Oh,Jong-Il Choi,Jin-Bae Kim,Jong-Chun Nah,Sung Il Im,Ki-Woon Kang,Seongwook Han,June Soo Kim 대한의학회 2020 Journal of Korean medical science Vol.35 No.2
Background: An implantable loop recorder (ILR) is an effective tool for diagnosing unexplained syncope (US). We examined the diagnostic utility of an ILR in detecting arrhythmic causes of US and determining which clinical factors are associated with pacemaker (PM) implantation. Methods: This retrospective, multicenter, observational study was conducted from February 2006 to April 2018 at 11 hospitals in Korea. Eligible patients with recurrent US received an ILR to diagnose recurrent syncope and document arrhythmia. Results: A total of 173 US patients (mean age, 67.6 ± 16.5 years; 107 men [61.8%]) who received an ILR after a negative conventional workup were enrolled. During a mean follow-up of 9.4 ± 11.1 months, 52 patients (30.1%) had recurrent syncope, and syncope- correlated arrhythmia was confirmed in 34 patients (19.7%). The ILR analysis showed sinus node dysfunction in 24 patients (70.6%), supraventricular tachyarrhythmia in 4 (11.8%), ventricular arrhythmia in 4 (11.8%), and sudden atrioventricular block in 2 (5.9%). Overall, ILR detected significant arrhythmia in 99 patients (57.2%) irrespective of syncope. Among patients with clinically relevant arrhythmia detected by ILR, PM implantation was performed in 60 (34.7%), an intra-cardiac defibrillator in 5 (2.9%), and catheter ablation in 4 (2.3%). In a Cox regression analysis, history of paroxysmal atrial fibrillation (PAF) (hazard ratio [HR], 2.34; 95% confidence interval [CI], 1.33–4.12; P < 0.01) and any bundle branch block (BBB) (HR, 2.52; 95% CI, 1.09–5.85; P = 0.03) were significantly associated with PM implantation. Conclusion: ILR is useful for detecting syncope-correlated arrhythmia in patients with US. The risk of PM is high in US patients with a history of PAF and any BBB.