http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Han Jianjun (검색결과 12 건)
- 무료
- 기관 내 무료
- 유료
-
Fabrication of TiO<sub>2</sub> Microrod with Desired Shapes from Rod-like Titanium Glycolate
Han, Jianjun,Zhang, Hua,Li, Yuanzhi,Zhao, Xiujian,Chen, Hong,Wu, Zhongkui,Kim, Sun-Jae,Park, Kyeong Soon Chemical Society of Japan 2007 Chemistry letters Vol.36 No.11
<P>Rod-like titanium glycolate was prepared by poly-condensation of TiCl<SUB>4</SUB>, ethylene glycol, and water. Focusing electronic beam on one side of a titanium glycolate microrod led to bending of the micro-rod at the irradiation part. Calcination of the polymer results in formation of rod-like titania. By controlling irradiation time and changing focus position of electronic beam, we realized controllable processing of titania microrod with desired shapes, which may be find application in nano or microdevices.</P>
-
Han Zhang,Yabing Li,Jianjun Xiao,Thomas Jordan 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.6
GASFLOW-MPI is a widely used scalable computational fluid dynamics numerical tool to simulate the fluidturbulence behavior, combustion dynamics, and other related thermalehydraulic phenomena in nuclearpower plant containment. An efficient scalable linear solver for the large-scale pressure equation is one ofthe key issues to ensure the computational efficiency of GASFLOW-MPI. Several advanced Krylov subspacemethods and scalable preconditioning methods are compared and analyzed to improve the computationalperformance. With the help of the powerful computational capability, the large eddy simulation turbulentmodel is used to resolve more detailed turbulent behaviors. A backward-facing step flow is performed tostudy the free shear layer, the recirculation region, and the boundary layer, which is widespread in manyscientific and engineering applications. Numerical results are compared with the experimental data in theliterature and the direct numerical simulation results by GASFLOW-MPI. Both time-averaged velocityprofile and turbulent intensity are well consistent with the experimental data and direct numericalsimulation result. Furthermore, the frequency spectrum is presented and a e5/3 energy decay is observedfor a wide range of frequencies, satisfying the turbulent energy spectrum theory. Parallel scaling tests arealso implemented on the KIT/IKET cluster and a linear scaling is realized for GASFLOW-MPI.
-
-
Jixiang Xu,Jianjun Wang,Jianping Han,Zhaolong Han,Jiahuang Tu,Zhanjie Li 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
The aim of this paper is to investigate the bolted end-plate beam to column (BEBC) joints with different strengthening strategies under fire through a parametric study by using a validated computational model. The current studies are mainly more focused on the mechanical behavior of a certain kind of reinforced or unreinforced BEBC joints at either room or fire alone, limiting investigations are available for a comprehensive stiffening strategy study of the BEBC joints under fire. Therefore, there is a need in improving the performance of BEBC joints with different stiffening strategies, the fire resistance comparison of these BEBC joints with different strengthening strategies under fire is of great interest. The analyses of the fire resistance behavior of the stiffened or unstiffened BEBC joints under fire were conducted by using a developed model that was established and validated by using the existing test results. A parametric study was conducted for BEBC joints with web stiffeners, end-plate stiffeners and web and end-plate stiffeners together under fire using the validated computational model. In order to better compare the fire resistance of BEBC joints with different strengthening strategies under a fire, 24 finite element models were established by considering different strengthening strategies and end-plate thicknesses. The results on different strengthening strategies and the end-plate thicknesses revealed the major impact of web stiffeners and end-plate web stiffener together, and the sensitivities of end-plate thickness for unreinforced BEBC joints. For the fire resistance of unreinforced and stiffened BEBC joints, the findings herein can provide a valuable reference for potential design recommendations.
-
MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7
Gao Fei,Han Jianjun,Jia Li,He Jun,Wang Yun,Chen Mi,Liu Xiaojun,He Xia 한국유전학회 2023 Genes & Genomics Vol.45 No.2
Background MicroRNAs (miRNAs) have been reported to play important roles in regulating natural killer (NK) cell cytotoxicity to cancer cells. Objective This study aimed to investigate the effects and potential mechanism of miR-30c in regulating NK cell cytotoxicity to lung cancer cells. Methods Primary NK cells were derived from the peripheral blood of lung cancer and normal participants. Exosomes were isolated and validated via transmission electron microscopy and nanoparticle tracking analysis. The levels of miR-30c, polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7) and proteins in PI3K/AKT pathway were determined using quantitative real-time polymerase chain reaction or western blot. Tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels and the cytotoxicity of effector NK cells to target lung cancer cells were measured via enzyme linked immunosorbent assay, cell apoptosis or xenograft experiments. The relationship between miR-30c and GALNT7 was analyzed by luciferase activity, RNA pull-down and RNA immunoprecipitation assays. And a xenograft mice model was established to verify the effect of miR-30c in regulating NK cell cytotoxicity to lung cancer cells in vivo. Results NK cell-derived exosomes carrying miR-30c, and miR-30c level was significantly downregulated in primary NK cells of lung cancer patients. MiR-30c overexpression promoted TNF-α and IFN-γ secretion and enhanced the cytotoxicity of interleukin 2 (IL-2)-treated NK cells to lung cancer cells, while knockdown of miR-30c played an opposite effect in regulating the cytotoxicity of NK cells to lung cancer cells. GALNT7 was a target of miR-30c and was negatively regulated by miR-30c. Besides, miR-30c targeted GALNT7 to exert its function in regulating NK cell cytotoxicity. Furthermore, GALNT7 prompted the activation of PI3K/AKT pathway in NK cells. Additionally, miR-30c overexpression enhanced NK cell cytotoxicity to lung cancer cells and inhibited tumor growth in vivo. Conclusion miR-30c enhanced NK cell cytotoxicity to lung cancer cells via decreasing GALNT7 and inactivating the PI3K/AKT pathway, suggesting that regulating miR-30c expression maybe a promising approach for enhancing NK cell-based antitumor therapies.
-
CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR‑1193
Gao Fei,Han Jianjun,Jia Li,He Jun,Wang Yun,Chen Mi 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4
Background: Increasing evidence has suggested that circular RNAs (circRNAs) play critical roles in breast cancer (BC) progression. However, the expression level and potential functional role of circRNA centrosomal protein 85 (circ- CEP85) in BC remains largely unknown. Here, we aimed to explore the role of circCEP85 in BC. Methods: The levels of circCEP85, insuline-like growth factor I (IGF1) mRNA and microRNA-1193 (miR-1193) were examined by quantitative real-time polymerase chain reaction. The protein level was measured by Western blot. Cell proliferation, migration, apoptosis, angiogenesis and stemness were assessed by cell counting kit-8, 5-ethynyl- 2’-deoxyuridine assay, transwell assay, flow cytometry, tube formation and sphere formation assays. Xenograft mouse models were conducted to evaluate the effect of circCEP85 in BC in vivo. Moreover, dual-luciferase reporter, RNA pulldown, and RNA immunoprecipitation (RIP) assays were preformed to confirm the interaction between miR-1193 and circCEP85 or IGF1. Results: CircCEP85 was upregulated in BC tissues and cells. Silencing of circCEP85 inhibited proliferation, invasion, angiogenesis and stemness, but promoted apoptosis in BC cells in vitro. In addition, circCEP85 silencing inhibited tumor growth in vivo. Mechanistically, circCEP85 elevated IGF1 expression via sponging miR-1193 to promote breast cancer progression. Conclusion: The circCEP85-miR-1193-IGF1 axis regulated BC progression via the competitive endogenous RNA (ceRNA) mechanism. CircCEP85 might be a prognostic biomarker and therapeutic target for BC.
-
Lv, Yongzhu,Li, Bing,Han, Kunna,Xiao, Yang,Yu, Xianjun,Ma, Yong,Jiao, Zhan,Gao, Jianjun The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the effect of MLN4924 on colon cancer cells (HCT116 and HT29). MLN4924 significantly inhibited the neddylation of cullin-1 and colon cancer cell growth in a time and dose-dependent manner. MLN4924 induced G2/M cell cycle arrest and apoptosis in HCT116 and HT29 cells. Moreover, MLN4924 also triggered autophagy in HCT116 and HT29 cells via suppressing the PI3K/AKT/mTOR pathway. Inhibiting autophagy by autophagy inhibitor 3-MA or ATG5 knockdown reversed the function of MLN4924 in suppressing colon cancer cell growth and cell death. Interestingly, MLN4924 suppresses colon cell growth in a xenograft model. Together, our finding revealed that blocking neddylation is an attractive colon cancer therapy strategy, and autophagy might act as a novel anti-cancer mechanism for the treatment of colon cancer by MLN4924.
-
-
Yongzhu Lv,Bing Li,Kunna Han,Yang Xiao,Xianjun Yu,Yong Ma,Zhan Jiao,Jianjun Gao 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the effect of MLN4924 on colon cancer cells (HCT116 and HT29). MLN4924 significantly inhibited the neddylation of cullin-1 and colon cancer cell growth in a time and dose-dependent manner. MLN4924 induced G2/M cell cycle arrest and apoptosis in HCT116 and HT29 cells. Moreover, MLN4924 also triggered autophagy in HCT116 and HT29 cells via suppressing the PI3K/AKT/mTOR pathway. Inhibiting autophagy by autophagy inhibitor 3-MA or ATG5 knockdown reversed the function of MLN4924 in suppressing colon cancer cell growth and cell death. Interestingly, MLN4924 suppresses colon cell growth in a xenograft model. Together, our finding revealed that blocking neddylation is an attractive colon cancer therapy strategy, and autophagy might act as a novel anti-cancer mechanism for the treatment of colon cancer by MLN4924.
-
Li, Yong,Li, Defa,Xing, Jianjun,Li, Shengli,Han, Yang,Han, In K. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.10
Thirty-six (20 wethers and 16 rams) adult Gansu highland finewool sheep with an average liveweight of $19.42{\pm}1.83kg$ were used. The sheep were allocated to 4 treatments and confined in individual feeding stalls. The 80 day feeding trial was divided into 2 periods of 38 and 42 days. The sheep had access to clean water and were fed chopped wheat straw ad libitum. Daily supplemented diets of 150 g for the first period and 200 g for the later period were provided. The 4 types of supplements were: Wheat bran type (I), which is the traditional feeding practice in the area and the control group; Linseed cake type (II); Linseed cake+poultry litter type (III); Poultry litter+distiller grains type (IV). The digestibility trial was conducted using a total collection method at the end of the first period in the feeding trial. The results showed that the digestibilities of DM, OM, CP, CF, NDF and ADF in group II and III were increased to more than 50%. CP and NDF digestibility in group II were significantly increased by 23.6% and 25.5% respectively over group I (p<0.01) and by 10.1% and 13.1% respectively over group III (p<0.05). The digestibility of DM, OM, CP, CF, NDF and ADF in group IV was lower than group I by 4.4 to 8.4% (p>0.05). Compared to group I, group II and III increased straw intake by 17.6% (p<0.01) and 10.8% (p<0.05). The ADG increased from 16.2 g in group I to 45.3 g and 32.8 g (p<0.01) in group II and III respectively. The ratio of supplement intake to gain decreased from 10.7 in group I to 3.9 and 5.4 (p<0.01) in group II and III respectively. The ratio of supplement cost to gain also decreased by 60.0% and 64.3%, respectively. The wool growth rate and wool strength in these 2 groups were noticeably improved. This significantly enhanced the wool's textile value. The above parameters in group IV were lower than in group I, except the ratio of supplement cost to gain. This research indicates that local low quality nitrogen resources could be used effectively and economically to improve the utilization of wheat straw fed to sheep on smallholder farms under harsh loess plateau conditions in the winter.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
