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Shin, H. D.,Park, K. S.,Park, B. L.,Cheong, H. S.,Cho, Y. M.,Lee, H. K.,Lee, J.-Y.,Lee, J.-K.,Kim, H. T.,Han, B. G.,Kim, J. W.,Koh, I.,Kim, Y. J.,Oh, B.,Kimm, K.,Park, C. Blackwell Science Ltd 2006 Diabetic medicine Vol.23 No.1
<P>Abstract</P><P>Aims </P><P>Growing evidence supports the hypothesis that chronic low-grade inflammation related to innate immunity may play an important role in the pathophysiology of Type 2 diabetes mellitus (T2DM). The monocyte differentiation antigen CD14 gene (<I>CD14</I>) acts as the receptor for lipopolysaccharide (LPS) and augments monocyte/macrophage inflammatory responses.</P><P>Methods </P><P>We have sequenced the gene, including all exons, exon/intron boundaries, and the −1.5 kb of the 5′ flanking region. Two common loci (minor allele frequency > 0.05) were genotyped in 775 T2DM patients and 316 control subjects recruited in the Korean T2DM Study.</P><P>Results </P><P>Eight polymorphisms, including four non-synonymous forms, were identified in <I>CD14</I>. No polymorphisms were found in association with T2DM. However, one common promoter SNP (<I>−260T>C</I>) was significantly associated with both the serum triglyceride level (TG) and body mass index (BMI) in non-diabetic control subjects. Individuals who carried the minor allele (C) had higher TG levels (1.65 ± 0.81 vs. 1.46 ± 0.80 mmol/l; <I>P</I> = 0.0007) and BMI (23.96 ± 3.00 vs. 23.28 ± 3.22 kg/m<SUP>2</SUP>; <I>P</I> = 0.04) as compared with subjects carrying T/T genotypes.</P><P>Conclusion </P><P>Our data suggest that lipid metabolism and obesity, important pathophysiological elements of T2DM and the metabolic syndrome, are regulated by complex mechanisms that include the CD14 gene polymorphism-mediated genetic propensity to non-specific inflammatory responses.</P>
한국 밀식사과원의 정지전정에 따른 수체생장과 생산성 및 경영효율 비교
정혜웅,김경훈,송태영,홍성일,한호균,김귀권,신종협,여덕환,김병철,박준권,Jung, H.W.,Kim, K.H.,Song, T.Y.,Hong, S.I.,Han, H.K.,Kim, K.K.,Shin, J.H.,Yeo, D.H.,Kim, B.C.,Park, J.K. 국립한국농수산대학교 교육개발센터 2017 현장농업연구지 = Journal of practical agricultural resear Vol.19 No.1
The present study conducted a comparison on tree growth and productivity of high-density apple orchards by several orchard management systems: making scaffolds by heading-back and thinning out pruning (T-1), maintaining scaffolds upward and bearing shoots downward (T-2), managing branches slightly upward without heading-back (T-3), keeping leaders downward and shoots pending (T-4), maintaining leaders high and branches horizontal with severe pinching (T-5), making leaders with lower branches vigorous and upper shoots pending (T-6), and controlling very high planting density with bending branches (T-7). In conclusion, the orchards of (T-5) and (T-6) management systems showed a superior performance in controlling tree growth, productivity, and quality of fruits. Also, superior management efficiency was obtained in the orchards of (T-5) and (T-6).
재래돼지 Melanocortin Receptor 1(MCIR)의 변이에 관한 연구
한재용,정일정,김태헌,윤두학,연성흠,최봉환,노환국,김남순,이화진 한국동물자원과학회 2001 한국축산학회지 Vol.43 No.3
The melanocortin 1 receptor (MC1R) gene is the major candidate gene for coat color in pig since it is assumed to be controlled by an allele at the Extension (E) locus. A 702 by fragments of the MC1R gene were amplified by PCR, cloned and sequenced from 6 heads of Korean native pig. Of them, 4 pigs possessed allele#2 which is associated with black coat color in pig, the others had allele#1 which revealed a unique allele in European wild boar reported by Kijas et al. (1998). PCR-RFLP was carried out to observe their alleles from 6 different pig breeds including Korean native pig, Berkshire, Duroc, Landrace, Large White, and Meishan pig. Two pairs of primers were designed for amplifying the MC1R gene fragment corresponding to five polymorphic sites. PCR products were digested 5 different restriction enzymes. Nsp I , MspA 1 I , Rca I , Hha I and Acc II , and electrophoresed in 2.5% Metaphor agarose gel. All breeds except for Korean native and Meishan breeds were the same alleles reported by Kijas et al. (1998). Of 9 Meishan pigs tested in this study, 4 heads possessed the same allele, 5 heads were different alleles reported by Kijas et al. (1998). A total of 15 different alleles revealed in Korean native pig. The results of this study strongly suggest that black coat color in Korean native breed was associated with a constitutively active receptor at codon 99 (L99P).
Du, H.I.,Han, B.S.,Kim, Y.J.,Lee, D.H.,Song, S.S.,Han, T.H.,Han, S.C. North-Holland 2011 Physica. C, Superconductivity Vol.471 No.21
The basic way to improve the performance of a superconducting current limiter is to apply and evaluate a superconducting device that is appropriate to the superconducting current limiter. Among the many types of superconducting devices, the YBCO thin film wire has excellent current-limiting performance that is appropriate for actual system application. For the application of the YBCO thin film wire to superconducting current limiters, its current-limiting performance as a unit device must be accurately evaluated, and measures to improve its current-limiting performance must be sought. Accordingly, to evaluate the current-limiting performance of the YBCO thin film wire, this study was conducted to evaluate its resistance-increasing trend, V<SUB>max</SUB>, T<SUB>r</SUB>, I<SUB>max</SUB>, I<SUB>qt</SUB>, and current-limiting rate as a unit device, after which the electric coupling condition that consists of a core and windings was used to evaluate the current-limiting performance of the YBCO thin film wire.