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A New Flavanone Glycoside from the Dried Immature Fruits of Poncirus trifoliata
HAN, Ah-Reum,KIM, Jong-Bin,LEE, Jun,NAM, Joo-Won,LEE, Ik-Soo,SHIM, Chang-Koo,LEE, Kyung-Tae,SEO, Eun-Kyoung 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18
A new flavanone glycoside, (2R)-5-hydroxy-4'-methoxyflavanone-7-0-{β-glucopyranosyl-(1->2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E₂ (PGE₂) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.
Han, Ah-reum,Kim, Moon-Jung,Kwak, Geun-Hee,Son, Jonghyeon,Hwang, Kwang Yeon,Kim, Hwa-Young American Chemical Society 2016 Biochemistry Vol.55 No.36
<P>Many bacteria, particularly pathogens, possess methionine sulfoxide reductase A (MsrA) and B (MsrB) as a fusion form (MsrAB). However, it is not clear why they possess a fusion MsrAB form rather than the separate,enzymes that exist in most organisms. In this study, we performed biochemical and kinetic analyses of MsrAB from Treponema denticola (TdMsrAB), single-domain forms (TdMsrA and TdMsrB), and catalytic Cys mutants (TdMsrAB(C11S) and TdMsrAB(C285S)) We found that the catalytic efficiency of both MsrA and MsrB increased after fusion of the domains and that the linker region (iloop) that connects TdMsrA and TdMsrB is required for the higher catalytic efficiency of TdMsrAB. We also determined the crystal structure of TdMsrAB at 2.3 angstrom, showing that the iloop mainly interacts with TdMsrB via hydrogen bonds. Further kinetic analysis using the iloop mutants revealed that the iloop-TdMsrB interactions are critical to MsrB and MsrA activities. We also report the structure in which an oxidized form of dithiothreitol, an in vitro reductant for MsrA and MsrB, is present in the active site of TdMsrA. Collectively, the results of this study reveal an essential role of the iloop in maintaining the higher catalytic efficiency of the MsrAB fusion enzyme and provide a better understanding of why the MsrAB enzyme exists as a fused form.</P>
A New Flavanone Glycoside from the Dried Immature Fruits of <i>Poncirus trifoliata</i>
Han, Ah-Reum,Kim, Jong-Bin,Lee, Jun,Nam, Joo-Won,Lee, Ik-Soo,Shim, Chang-Koo,Lee, Kyung-Tae,Seo, Eun-Kyoung Pharmaceutical Society of Japan 2007 Chemical & pharmaceutical bulletin Vol.55 No.8
<P>A new flavanone glycoside, (2<I>R</I>)-5-hydroxy-4′-methoxyflavanone-7-<I>O</I>-{β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of <I>Poncirus trifoliata</I>, together with three known compounds, (2<I>S</I>)-poncirin (2), (2<I>S</I>)-naringin (3), and (2<I>S</I>)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.</P>
Han, Ah-Reum,Kang, You-Jin,Windono, Tri,Lee, Sang Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
A new prenlated chalcone, 3"",3"" -dimethylpyrano[3',4']2,4,2' -trihydroxychalcone(1), was isolated from the heartwood of Artocarpus communis. Two flavonoid derivatives, (-)-cycloartocarpin(9) and (-)-cudraflavone A(10), were isolated as new isomers. In addition, eight known flavonoids, isobacachalcone(2), morachalcone A(3), gemichalcones B(4) and C(5), artocarpin(6), cudraflavone C(7), licoflavone C(8), and (2S)-euchrenone a_(7)(11), were isolated and identified from this plant for the first time. Compounds 1-4.6, and 11 exhibited potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC_(50) values of 18.8, 6.4, 16.4, 9.3, 18.7, and 12.3, μM, respectively. The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments.
Han, Ah-Reum,Kim, Hyo Young,So, Yangkang,Nam, Bomi,Lee, Ik-Soo,Nam, Joo-Won,Jo, Yeong Deuk,Kim, Sang Hoon,Kim, Jin-Baek,Kang, Si-Yong,Jin, Chang Hyun Hindawi 2017 International journal of analytical chemistry Vol.2017 No.-
<P>The flowers of<I> Chrysanthemum morifolium</I> Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (<I>C. morifolium</I> cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar with purple striped white petals (<I>C. morifolium</I> cv. Noble Wine, NW). The phenolic profile and antioxidant property of ADC were investigated and compared with NW and the commercially available medicinal herb,<I> C. morifolium</I> with yellow petals (CM), in order to find a scientific support to produce a new source of natural antioxidant. Flavonoid and phenolic acid profiles of the ethanol extracts of the three flowers were analyzed by high-performance liquid chromatography-diode array detector-electrospray ionization mass spectrometry (HPLC-DAD-ESIMS), while antioxidant properties were evaluated using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assay. Among the tested flowers, ADC possessed the strongest antioxidant capacity and the highest phenolic contents. Flavonoids (acacetin, apigenin, luteolin, acacetin-7-<I>O</I>-<I>β</I>-glucoside, apigenin-7-<I>O</I>-<I>β</I>-glucoside, luteolin-7-<I>O</I>-<I>β</I>-glucoside, and linarin) and phenolic acids (chlorogenic acid and mixture of 1,4-, 1,5-, and 3,5-dicaffeoylquinic acids) were identified and quantified.</P>
A Potential Cytotoxic Principle of Zingiber cassumunar
Han, Ah-Reum,Lee, Eun-Jin,Min, Hye-Young,Kim, Hyang-Rim,Lee, Sang Kook,Seo, Eun-Kyoung 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3',4'-dimethoxyphenyl)but-3-en-l-ol (2) and (E)-4-(3',4'-dimethoxyphenyl)but-3-en-l-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC_(50) 18.80㎍/㎖).
Han, Ah-reum,Kang, Hye-Ri,Son, Jonghyeon,Kwon, Do Hoon,Kim, Sulhee,Lee, Woo Cheol,Song, Hyun Kyu,Song, Moon Jung,Hwang, Kwang Yeon Oxford University Press 2016 Nucleic acids research Vol.44 No.19
<P>GTP and branched-chain amino acids (BCAAs) are metabolic sensors that are indispensable for the determination of the metabolic status of cells. However, their molecular sensing mechanism remains unclear. CodY is a unique global transcription regulator that recognizes GTP and BCAAs as specific signals and affects expression of more than 100 genes associated with metabolism. Herein, we report the first crystal structures of the full-length CodY complex with sensing molecules and describe their functional states. We observed two different oligomeric states of CodY: a dimeric complex of CodY from <I>Staphylococcus aureus</I> with the two metabolites GTP and isoleucine, and a tetrameric form (apo) of CodY from <I>Bacillus cereus</I>. Notably, the tetrameric state shows in an auto-inhibitory manner by blocking the GTP-binding site, whereas the binding sites of GTP and isoleucine are clearly visible in the dimeric state. The GTP is located at a hinge site between the long helical region and the metabolite-binding site. Together, data from structural and electrophoretic mobility shift assay analyses improve understanding of how CodY senses GTP and operates as a DNA-binding protein and a pleiotropic transcription regulator.</P>
Han, Ah-Reum,Kim, Jongtae,Yang, Il-Hyung The Korean Association Of Orthodontists 2021 대한치과교정학회지 Vol.51 No.1
Objective: The aim of this study was to evaluate the correlation between the vertical position of maxillary first molar and vertical skeletal measurements in lateral cephalograms by using new linear measurements on the vertical axis of coordinates with calibration. Methods: The vertical position of maxillary first molar (U6-SN), and the conventionally used variables (ConV) and the newly derived linear variables (NwLin) for vertical skeletal patterns were measured in the lateral cephalograms of 103 Korean adults with normal occlusions. Pearson correlation analyses and multiple linear regression analyses were performed with and without calibration using the anterior and posterior cranial base (ACB and PCB, respectively) lengths to identify variables related to U6-SN. Results: The PCB-calibrated statistics showed the best power of explanation. ConV indicating skeletal hyperdivergency was significantly correlated with U6-SN. Six NwLin regarding the position of palatal plane were positively correlated with U6-SN. Each multiple linear regression analysis generated a two-variable model: sella and nasion to palatal plane. Among the three models, the PCB-calibrated model yielded highest adjusted R2 value, 0.880. Conclusions: U6-SN could be determined by the vertical position of the maxilla, which could then be used to plan the amount of molar intrusion and estimate its clinical stability. Cephalometric calibration on the vertical axis of coordinates by using PCB for vertical linear measurements could strengthen the analysis itself.
Topoisomerase-II-Inhibitory Principles from the Stems of Spatholobus suberectus
Han, Ah-Reum,Park, Hyen ,Joo,Chen, Daofeng,Jang, Dae ,Sik,Kim, Hwa-Jung,Lee, Sang ,Kook,Seo, Eun-Kyoung VERLAG HELVETICA CHIMICA ACTA AG 2007 Chemistry & Biodiversity Vol. No.
<P>Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(−)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin-(4→8)-(−)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC<SUB>50</SUB> values of 22.5±2.3 and 21.9±2.2 nM, resp.</P>