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        Microstructure Analysis of the Pack Cementation Aluminide Coatings Modified by CeO2 Addition

        Hamid Zahedi,Farhad Shahriari Nogorani,Mahdi Safari 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5

        Minor additions of reactive elements (Y, Ce, Hf, etc.) can improve the oxidation behavior of high temperature alloys andcoatings such as aluminide coatings. In the current investigation cerium-modified aluminide coatings were developed viaadditions of CeO2to the powder mixture of high activity pack cementation aluminizing. Nickel-based substrates were aluminizedat 750 °C and then diffusion annealed at 1080 °C. Microstructure of the coatings was studied using scanning electronmicroscopy, energy dispersive spectroscopy and X-ray diffraction. The results were compared with the characterization resultsof specimens achieved by aluminizing an electrodeposited Ni–CeO2 interlayer at 1030 °C. The coatings modified by CeO2addition to the pack showed a dense Al-rich NiAl surface layer with cerium distributed in the coating, however, the coatingsmodified by Ni–CeO2 interlayer revealed a porous Ni-rich aluminide layer containing CeO2particles. Increasing the CeO2content of the pack decreased the thickness of the final coating, but the presence of CeO2particles in the interlayer increasedthe thickness of the final aluminide coating. The observed microstructural features were explained using thermodynamicanalysis of equilibrium concentration of the involved gaseous species.

      • Incidence, Trends and Epidemiology of Cancers in North West of Iran

        Zahedi, Atefeh,Rafiemanesh, Hosein,Enayatrad, Mostafa,Ghoncheh, Mahshid,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: Cancer is a leading cause of death throughout the world. Increasing life expectancy and aging population are important factors for increasing cancer incidences in developing countries. National programs are essential for prevention and control of cancer in any society. This study aimed to investigate cancer epidemiology and trends in the province of Hamadan, located in Northwest Iran. Materials and Methods: This analytical study was carried out based on cancer registry data from 2004 to 2009 in the province of Hamadan, analyzed using STATA (version 12) software for descriptive tests and Join point 4.1.1.1 software for analytical tests. Results: There were 7,767 registered cases of cancer during the 6 years studied. Of the total cases registered, 59.1% (4,592 cases) involved men and 40.9% (3,175 cases) occurred in women. Age-standardized incidence rates (ASR) increased from 72.9 to 132.0 in males and 48.2 to 115.0 in females during the 6 years of the study (p<0.001). The most common cancers were skin, stomach, breast, bladder, and leukemia. In women, teh most common were breast, skin, stomach, colorectal, and leukemia, in that order, and in men skin, stomach, bladder, leukemia, and prostate cancers. Conclusions: The cancer incidence is greater in men that women in this region but with increasing trends in both sexes. Planning regarding education in prevention of exposure to risk factors and control strategies is required to decrease the incident cases. Screening programs for common cancers in older age groups might be helpful to reduce the disease impact.

      • Evaluation of the Frequency of the IL-28 Polymorphism (rs8099917) in Patients with Chronic Hepatitis C Using Zip Nucleic Acid Probes, Kerman, Southeast of Iran

        Iranmanesh, Zahra,Mollaie, Hamid Reza,Arabzadeh, Seyed Alimohammad,Zahedi, Mohammad Javad,Fazlalipour, Mehdi,Ebrahimi, Saeede Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Polymorphisms in the region of the interleukin IL-28 gene on chromosome 19 have been related with clearance of hepatitis C virus (HCV), a major human pathogen responsible for chronic hepatitis, cirrhosis and hepatocellular carcinoma. About 3% of the world's population is infected with HCV. The long-term response to therapy is influenced by many host and viral factors, and recent evidence has indicated that some host genetic polymorphisms related to IL-28 are the most powerful predictors of virological response in patients with HCV. This study assessed frequency of the IL-28 polymorphism (rs8099917) in 50 patients (39 men and 11 women) with chronic hepatitis C using ZNA probe real time PCR new method. All patients were tested for genotype of HCV and the HCV viral load. In parallel, the levels of SGOT, SGPT and ALK enzymes were assessed. Treatment using Peg-interferon alpha with ribavirin was conducted for patients and subsequently samples were collected to detect any change in viral load or liver enzyme rates. The overall frequency of the TT allele is 74%, TG allele 20% and GG allele 6% and the percent of patients who had T allele was 84%. Clear reduction in viral load and liver enzymes was reported in patients with the T allele. Especially for genotype 1 which is relatively resistant to treatment, these alleles may have a role in this decline. In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.

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