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RISS 인기검색어
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- 저자 : Hamed Tayebee (검색결과 2 건)
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Pashaki, Abdolazim Sedighi,Hamed, Ehsan Akbari,Mohamadian, Kamal,Abassi, Mohammad,Safaei, Afsane Maddah,Torkaman, Tayebe Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Glioblastoma multiform (GBM) is a highly aggressive tumor with median survival of approximately 14 months. Management consists of maximal surgical resection followed by post-operative chemoradiation with concurrent then adjuvant temozolamide. The standard radiotherapy dose is 60Gy in 2-Gy fractions recommended by the radiation therapy oncology group (RTOG). With the vast majority of tumor recurrences occurring within the previous irradiation field and the poor outcome associated with standard therapy, regimens designed to deliver higher radiation doses to improve local control and enhance survival are needed. In this study, we report a single institutional experience in treatment of 68 consecutive patients with GBM, treated with resection, and given post-operative radiotherapy followed by concurrent and/or adjuvant chemotherapy. Results: Of the 80 patients who entered this study, 68 completed the treatment course; 45 (66.2%) males and 23 (33.8%) females with a mean age at diagnosis of $49.0{\pm}12.9$ (21-75) years. At a median follow up of 19 months, 39 (57.3%) patients had evidence of tumor progression and 36 (52.9%) had died. The median over all survival for all patients was 16 months and progression free survival for all patients was 6.02 months. All potential prognostic factors were analyzed to evaluate their effects on overall survival. Age ${\leq}50$ year, concurrent and adjuvant chemotherapy and extent of surgery had significant p values. We found lower progression rate among patients who received higher doses of radiotherapy (>60Gy). Higher radiation doses improved progression free survival (p=0.03). Despite increasing overall survival, this elevation was not significant. Conclusions: This study emphasize that higher radiation doses of (>60Gy) can improve local control and potentially survival, so we strongly advise prospective multi centric studies to evaluate the role of higher doses of radiotherapy on GBM patient outcome.
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Modeling the Problem of Choosing an Optimal Strategy to Respond to Project Risks
Fahimeh Rezaee,Majid Sabzeparvar,Hamed Tayebee 대한산업공학회 2018 Industrial Engineeering & Management Systems Vol.17 No.4
The project risk management is a systematic process of identifying, analyzing and responding to project risks in orderto maximize results of positive events and minimize consequences of bad and negative events that can affect mainobjectives of the project. In this process, the phase of risk response is a very important phase; because the effectivenessof responses directly determines increase or decrease of the project risk. Planning risk responses is the process ofidentifying different options and actions for reducing or eliminating threats and increasing or exploiting opportunitiesrelated to objectives of the project. Therefore, in this research, a systematic approach which is a combination of fuzzymulti-objective decision-making methods and zero-one integer programming model, is proposed to select the bestsolutions for responding to project risks. Also, since project risk management process has different stages, the stagesbefore accountability phase include identifying and analyzing quality of the risks, and choosing critical risks is alsodone for accountability. Finally, in order to select the best solution for each of the critical risks, a zero-one multiobjectivemathematical model is presented in a fuzzy environment and a case study is carried out on the Khangirangas field (Shourijeh).
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