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박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1
We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.
Inhibitory Effect of Cordycepin on Human Platelet Aggregation
박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1
Cordycepin separated from Cordyceps militaris is a major physiologic active component in Cordyceps militaris. The platelet aggregation is stimulated by Ca^(2+), which is either mobilized from intracellular endoplasmic reticulum or transported from extracellular space. cGMP antagonizes the actions of Ca^(2+). Based on these facts, we have investigated the effects of cordycepin on the mobilization of Ca^(2+) and the production of cGMP on collagen (10 ㎍/ml)-induced human platelet aggregation. Cordycepin potently stimulated the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. Cordycepin (500 μM) inhibited also the collagen-induced human platelet aggregation in the presence both 1 mM and 2 mM of CaCl_(2). These are in accord with the results that cordycepin inhibited the Ca^(2+)-influx on collagen-induced human platelet aggregation. These results suggest that cordycepin decrease the intracellular Ca^(2+) concentration to inhibit collagen-induced human platelet aggregation. Besides, cordycepin increased the level of cGMP on collagen-induced human platelet aggregation. This result is related with the decrease of intracellular Ca^(2+) concentration, because cGMP inhibits the mobilization of Ca^(2+). In addition, cordycepin inhibited the human platelet aggregation induced by LY-83583, inhibitor of guanylate cyclase. This result suggested that cordycepin inhibit the platelet aggregation by stimulating the activity of guanylate cyclase. In conclusion, we demonstrated that cordycepin might have the antiplatelet function by inhibiting Ca^(2+)-mobilization via the stimulation of the production of cGMP.
Integrated Ray Tracing Model for In-Orbit Optical Performance Simulation for GOCI
Ham, Sun-Jeong,Lee, Jae-Min,Kim, Seong-Hui,Youn, Heong-Sik,Kang, Gm-Sil,Myung, Hwan-Chun,Kim, Sug-Whan 통신위성우주산업연구회 2006 Joint Conference on Satellite Communications Vol.2006 No.-
GOCI (Geostationary Ocean Color Imager) is one of the three COMS payloads that KARl is currently developing and scheduled to be in operation from around 2008. Its primary objective is to monitor the Korean coastal water environmental condition. We report the current progress in development of the integrated optical model as one of the key analysis tools for the GOCI in-orbit performance verification. The model includes the Sun as the emitting light source. The curved Earth surface section of 2500 km x 2500 km including the Korean peninsular is defined as a Lambertian scattering surface consisted of land and sea surfaces. From its geostationary orbit, the GOCI optical system observes the reflected light from the surfaces with varying reflectance representing the changes in its environmental conditions. The optical ray tracing technique was used to demonstrate the GOCI in-orbit performances such as red tide detection. The computational concept, simulation results and its implications to the on-going development of GOCI are presented.
Association between ED crowding and delivery of medications to critical patients with hyperkalemia
( Sun Hee Moon ),( Ki Jeong Hong ),( Jong Hwan Shin ),( Jin Kim ),( Kyoung Hwa Lim ),( Chun Sun Ham ),( Jin A Choi ),( Ji Hee Kang ),( Jung Mee Han ),( Su Yong Shin ),( Sun Young Kim ),( Sung Wook Son 대한응급의학회 2013 대한응급의학회 학술대회초록집 Vol.2013 No.2
Background: The effect of ED crowding on delay of treatment to critically ill patients is controversial. Few investigations have been evaluated whether ED crowding delayed delivery of medications to critically ill patients with hyperkalemia. The purpose of this study is to investigate association between ED crowding and delay in managing critically ill patients with hyperkalemia. Methods: This study was conducted at the emergency department located in metropolitan area. We retrospectively reviewed medical records from Jan to Dec 2011. Inclusion criteria was critically ill adult patient (ESI level with 1, 2) with hyperkalemia (initial electrolyte test: potassium >5.0 mmol/L) who was given regular insulin via IV access during ED stay. ED crowding was measured by hourly number of ED visits. Crowed ED was defined by upper quartile of hourly ED visits. Delivery time of medications was measured by minutes from ED visit to infusion time of regular insulin to the patients in nursing records. We performed descriptive analysis and multivariate linear regression adjusted for age, sex, EMS use, nursing duty time, injury. Results: During study period, 45,520 adults visited ED and 1,098 cases showed laboratory result of hyperkalemia. Among them, 123 hyperkalemia cases were triaged by ESI 1, 2 and given regular insulin. 35(28.5%) of enrolled cases visited crowded ED and 88(71.5%) visited non-crowded ED. There was no significant difference of demographics, EMS use and presence of injury between two groups. Delivering time of regular insulin to hyperkalemia case was significantly longer in crowded group than non-crowded (124.7±145.0 vs 76.0±83.3, p<0.01, minutes). In multivariate linear regression, visiting crowded ED delayed delivery time of regular insulin (43.0 minutes, 95% CI: 3.3-82.7). Conclusion: ED crowding delayed delivery of medications to critically ill patients with hyperkalemia. ED crowding could affect quality of medical care for emergency patients with high acuity.