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On the Order of Growth of Solutions to Complex Non-homogeneous Linear Differential Equations
Habib, Habib,Belaidi, Benharrat Department of Mathematics 2016 Kyungpook mathematical journal Vol.56 No.3
In this paper, we study the order of growth of solutions to the non-homogeneous linear differential equation $$f^{(k)}+A_{k-1}e^{az}f^{(k-1)}+{\cdots}+A_1e^{az}f^{\prime}+A_0e^{az}f=F_1e^{az}+F_2e^{bz}$$, where $A_j(z)$ (${\not\equiv}0$) ($j=0,1,{\cdots},k-1$), $F_j(z)$ (${\not\equiv}0$) (j = 1, 2) are entire functions and a, b are complex numbers such that $ab(a-b){\neq}0$.
Habib, Omer,Habib, Gizem,Moon, Sung-Hwan,Hong, Ki-Sung,Do, Jeong Tae,Choi, Youngsok,Chang, Sung Woon,Chung, Hyung-Min Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.1
Induced pluripotent stem cells (iPSCs) are capable of unlimited self-renewal and can give rise to all three germ layers, thereby providing a new platform with which to study mammalian development and epigenetic reprogramming. However, iPSC generation may result in subtle epigenetic variations, such as the aberrant methylation of the Dlk1-Dio3 locus, among the clones, and this heterogeneity constitutes a major drawback to harnessing the full potential of iPSCs. Vitamin C has recently emerged as a safeguard to ensure the normal imprinting of the Dlk1-Dio3 locus during reprogramming. Here, we show that vitamin C exerts its effect in a manner that is independent of the reprogramming kinetics. Moreover, we demonstrate that reprogramming cells under 2i conditions leads to the early upregulation of Prdm14, which in turn results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1-Dio3 locus.
An improved method for the derivation of high quality iPSCs in the absence of c-Myc
Habib, O.,Habib, G.,Choi, H.W.,Hong, K.S.,Tae Do, J.,Moon, S.H.,Chung, H.M. Academic Press 2013 Experimental cell research Vol.319 No.20
Induced pluripotent stem cells (iPSCs) hold tremendous potential for the development of new regenerative medicine therapies and the study of molecular mechanisms of pluripotency and development. However, reactivation of c-Myc, which results in tumor formation in chimeric mice, is a major roadblock in the translation of iPSCs into therapies. Although ectopic expression of c-Myc is not absolutely required for somatic reprogramming, in the absence of c-Myc, the overall efficiency of reprogramming is drastically reduced and the reprogramming time is increased. Subtle, abnormal epigenetic modifications in iPSCs derived in the absence of c-Myc have also been documented. Therefore, we developed a reprogramming method without c-Myc to generate high-quality iPSCs, a prerequisite to harnessing the full potential of iPSCs. In this study, we determined that serum replacement (SR)-based culture conditions dramatically increased the transcription factor-mediated reprogramming of mouse embryonic fibroblast cells (MEFs). The process was shortened to approximately 8 days when Oct4/Sox2/Klf4 (3F)-transduced MEFs were first cultured for 3 days under low serum conditions (LS protocol). The 3F-derived iPSCs that were generated by this method resembled mouse ES cells (mESCs) in morphology, gene expression, and in vitro differentiation. Finally, we observed that 3F-derived iPSC colonies were able to reach definite pluripotency in terms of molecular signatures when the catalytic function of c-Myc was tolerated. The 3F induction of pluripotency described here should facilitate the use of iPSCs and may also facilitate the mechanistic dissection of somatic reprogramming.
habib omer,Gizem Habib,문성환,홍기성,도정태,Youngsok Choi,장성운,정형민 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.1
Induced pluripotent stem cells (iPSCs) are capable of unlimited self-renewal and can give rise to all three germ layers, thereby providing a new platform with which to study mammalian development and epigenetic reprogramming. However, iPSC generation may result in subtle epigenetic variations, such as the aberrant methylation of the Dlk1-Dio3 locus, among the clones, and this heterogeneity constitutes a major drawback to harnessing the full potential of iPSCs. Vitamin C has recently emerged as a safeguard to ensure the normal imprinting of the Dlk1-Dio3 locus during reprogramming. Here, we show that vitamin C exerts its effect in a manner that is independent of the reprogramming kinetics. Moreover, we demonstrate that reprogramming cells under 2i conditions leads to the early upregulation of Prdm14, which in turn results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1-Dio3 locus.
Habib Pardes,Jung Jennifer,Wilms Gina Maria,Kokott-Vuong Alma,Habib Shahin,Schulz Jörg B.,Voigt Aaron 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Hypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high. More basic research is needed to explain mortality after reperfusion and to develop adjunct neuroprotective therapies. Drosophila melanogaster (D.m.) is a suitable model to analyze hypoxia; however, little is known about the impacts of hypoxia and especially of the subsequent reperfusion injury on the behavior and survival of D.m . To address this knowledge gap, we subjected two wild-type D.m . strains (Canton-S and Oregon-R) to severe hypoxia (<0.3% O 2 ) under standardized environmental conditions in a well-constructed hypoxia chamber. During posthypoxic reperfusion (21% O 2 ), we assessed fly activity (evoked and spontaneous) and analyzed molecular characteristics (oxidative stress marker abundance, reactive oxygen species (ROS) production, and metabolic activity) at various timepoints during reperfusion. First, we established standard conditions to induce hypoxia in D.m . to guarantee stable and reproducible experiments. Exposure to severe hypoxia under defined conditions impaired the climbing ability and reduced the overall activity of both D.m . strains. Furthermore, a majority of the flies died during the early reperfusion phase (up to 24 h). Interestingly, the flies that died early exhibited elevated activity before death compared to that of the flies that survived the entire reperfusion period. Additionally, we detected increases in ROS and stress marker (Catalase, Superoxide Dismutase and Heat Shock Protein 70) levels as well as reductions in metabolic activity in the reperfusion phase. Finally, we found that changes in environmental conditions impacted the mortality rate. In particular, decreasing the temperature during hypoxia or the reperfusion phase displayed a protective effect. In conclusion, our data suggest that reperfusion-dependent death might be associated with elevated temperatures, predeath activity, and oxidative stress.
Effect of uncertainty parameters on graphene sheets Young’s modulus prediction
Habib Sahlaoui,Mohamed Guedri,Habib Sidhom 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.9
Software based on molecular structural mechanics approach (MSMA) and using finite element method (FEM) has been developed to predict the Young’s modulus of graphene sheets. Obtained results have been compared to results available in the literature and good agreement has been shown when the same values of uncertainty parameters are used. A sensibility of the models to their uncertainty parameters has been investigated using a stochastic finite element method (SFEM). The different values of the used uncertainty parameters,such as molecular mechanics force field constants r k and kθ , thickness (t) of a graphene sheet and length ( B L ) of a carboncarbon bonds, have been collected from the literature. Strong sensibilities of 91% to the thickness and of 21% to the stretching force ( r k )have been shown. The results justify the great difference between Young’s modulus predicted values of the graphene sheets and their large disagreement with experimental results.
Habib Hussain Khan,Abdul Ghafoor,Fiza Qureshi,Ijaz Ur Rehman 연세대학교 동서문제연구원 2018 Global economic review Vol.47 No.2
We empirically examine the role of the banking market structure and financial development for the growth of manufacturing and the financially dependent industries in China over the period of 1999–2014. We use both structural and non-structural approaches to assess the banking market structure and relate them to the growth of the manufacturing industries. The results of the study indicate that bank competition inspires industrial growth, particularly the growth of the financially dependent industries. Our findings further suggest that bank concentration undermines the growth of manufacturing industries in general and growth of the financially dependent industries in particular. These results are consistent across a number of sensitivity checks covering alternative measures of financial dependence, institutional factors such as property rights, quality of accounting standards and bank ownership and endogeneity consideration.
ACCELERATED LIFE TESTING OF A MILD HYBRID POWERTRAIN USING ARRHENIUS EQUATION
Habib Kaymaz 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.5
Electrification of city buses, which play a major role in public transportation, is imperative for efficient use of limited resources and reducing adverse effects of fossil fuels on the environment. One of the vital processes in electrification projects in the automotive industry is testing. The main target of testing is to achieve a reliable and reproducible test that simulates real-world driving conditions to disclosure any weakness of the product at the early stage of the life cycle. Other side targets of testing are to achieve the main target with low cost and environmentally friendly testing. In this study, results of research and development in accelerated life test stand for a mild hybrid system is described. The realized test stand serves to product reliability by enabling life tests with in excess of its normal service parameters real-world driving conditions such as revolution, electrical power, high ambient temperature, cooling effect, and rest-bus CAN simulation. By using temperature as a stress factor for the mild hybrid powertrain under test, life test duration was shortened 4.65 times according to the Arrhenius equation. Thanks to the realized test stand, the mild hybrid life test was achieved by decreasing time and cost.