http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Recombinant TRPV1 as a Potential Material for Detecting Several Agonists with FET Sensor
Siyoung HA,Oh Seok KWON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is an appear target for the treatment of pain with a unique expression profile in marginal nociceptors and the ability to show various activation. Several agonists of endogenous and exogenous nature have been described for ion channel. TRPV1 initially identified as the receptor for interaction with capsaicin, temperature greater than 43 °C, acidic conditions and leads to a painful, burning sensation. Based on this, the objective of this study was to test the antigenic potential of the recombinant TRPV1 protein for subsequent use in diagnostic tests. The TRPV1 expressed in the Escherichia coli strain BL21 was conformed from experimentally using ELISA and Western blotting and then the recombinant TRPV1 were applied with the surface of receptor to detect target material and improve sensing performance. Finally, we demonstration of the liquid-ion gated system based GFET biosensor for detection of TRPV1 receptor’s agonists, with highly sensitivity, selectivity and rapid responses in real-time.
Siyoung Ha,Oh Seok Kwon 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
The ACE2 is an appear target for the spike SI protein on Coronavirus specifically SARS-CoV and SARS-CoV-2. The expression of ACE2 in cortical neurons and glials makes them susceptible to SARS-CoV and CoV-2 attack, a possible basis for the occurrence of olfactory syndrome and neurological deficits seen in COVID-19. When the Spike SI protein binds to the enzymatic domain of ACE2 on the cell surface, viruses and enzymes are transfected into the cell. Based on this, the objective of this study was to test the antigenic potential of the recombinant ACE2 protein for subsequent use in diagnostic test.
HA, SIYOUNG,CHOI, JAESUNG,MIN, NA YOUNG,LEE, KWANG-HO,HAM, SEUNG WOOK Potamitis Press 2017 Anticancer research Vol.37 No.5
<P>Background: The design and synthesis of novel chemotherapeutic agents that can induce apoptosis and cell-cycle arrest has emerged as an attractive approach for the treatment of cancer, because they can limit possible nonspecific effects of compound treatment. Previous studies established that the expression of KPNB1 was increased in several cancer cells and transformed cell lines and inhibition of KPNB1 using siRNA significantly inhibited cervical tumour proliferation, but did not affect normal cervical epithelium. Recently, we reported that a KPNB1 inhibitor, the 2-aminothiazole derivative 1, possesses strong anti-proliferative effects against several cancer cells in the nanomolar concentration range. Results: Treatment with compound 1 interferes with cell-cycle progression in the G2/M phase, as detected by flow cytometry analysis and results in apoptosis by the intrinsic pathway. Fluorescence microscopic analysis of mitotic cells predominantly mitotic abnormal cells with monopolar spindles and treatment with compound 1 did not affect polymerization of microtubules. Conclusion: Compound 1, as a KPNB1 inhibitor, might be a good target for future development of anticancer agents showing the activities of apoptosis and cell cycle arrest.</P>
하시영(Siyoung Ha) 한국진공학회 2020 진공 이야기 Vol.7 No.2
The COVID-19 pandemis has spread to 214 countries and it was officially declared as a Pandemic by the WHO on the 11<SUP>th</SUP> March 2020. Its’s quickly evolving, as human-to-human transmission is occurring, and the number of mortalities and new cases is increasing by the day worldwide. The Pandemic has a long history and we can’t predict in the future about what mutations occur and how the virus spreads. The main ain of this Announcement is to provide information of present pandemic and diagnostic methods we will look at wats to prevent future disease X and Pandemic based on current literature.
Lee, Siyoung,Choi, Dong-Ki,Kwak, Areum,Kim, Sinae,Nguyen, Tam Thanh,Gil, Gaae,Kim, Eunhye,Yoo, Kwang Ha,Kim, In Ae,Lee, Youngmin,Jhun, Hyunjhung,Chan, Edward D.,Bai, Xiyuan,Kim, Hyunwoo,Kim, Yong-Sung 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial in graft versus host disease (GvHD) that is a common side effect of allogeneic BM transplantation. Clinical trials on α-1 antitrypsin (AAT) in patients with GvHD are based on the preliminary human and mouse studies on AAT reducing the severity of GvHD. Proteinase 3 (PR3) is an IL-32-binding protein that was isolated from human urine. IL-32 primarily induces inflammatory cytokines in myeloid cells, probably due to PR3 expression on the membrane of the myeloid lineage cells. The inhibitory activity of AAT on serine proteinases may explain the anti-inflammatory effect of AAT on GvHD. However, the anti-inflammatory activity of AAT on BM cells remains unclear. Mouse BM cells were treated with IL-32γ and different inflammatory stimuli to investigate the anti-inflammatory activity of AAT. Recombinant AAT-Fc fusion protein inhibited IL-32γ-induced IL-6 expression in BM cells, but failed to suppress that induced by other stimuli. In addition, the binding of IL-32γ to PR3 was abrogated by AAT-Fc. The data suggest that the specific anti-inflammatory effect of AAT in mouse BM cells is due to the blocking of IL-32 binding to membrane PR3.</P>