http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hyojeong Kim,Yoonjung Cho,Jeongyong Kim,Ja Hyun Lee,Hyo Sook Kim,Eungsoo Kim 대한의생명과학회 2020 Biomedical Science Letters Vol.26 No.4
Since its introduction in the forensic field, quantitative PCR (qPCR) has played an essential role in DNA analysis. Quality of DNA should be evaluated before short tandem repeat (STR) profiling to obtain reliable results and reduce unnecessary costs. To this end, various human DNA quantification kits have been developed. Among these kits, the PowerQunat<SUP>®</SUP> System was designed not only to determine the total amount of human DNA and human male DNA from a forensic evidence item, but also to offer data about degradation of DNA samples. However, a crucial limitation of the PowerQunat<SUP>®</SUP> System is its high cost. Therefore, to minimize the cost of DNA quantification, we evaluated kit performance using a reduced volume of reagents (1/2-volume) using DNA samples of varying types and concentrations. Our results demonstrated that the low-volume method has almost comparable performance to the manufacturer"s method for human DNA quantification, human male DNA quantification, and DNA degradation index. Furthermore, using a reduced volume of regents, it is possible to run 2 times more reactions per kit. We expect the proposed low-volume method to cut costs in half for laboratories dealing with large numbers of DNA samples.
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Kim, Mira,Jeon, Jiyoung,Baek, Jongouk,Choi, Jaeyul,Park, Eun Ju,Song, Jiyeon,Bang, Hyojeong,Suh, Kwee Hyun,Kim, Young Hoon,Kim, Jongmin,Kim, Doran,Min, Kyung Hoon,Lee, Kwang-Ok Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Efficacy of reduced-size short tandem repeat PCR analysis for degraded DNA samples
Jeongyong Kim,Hyojeong Kim,Youn‑Hyoung Nam,Ja Hyun Lee,Hyo Sook Kim,Eungsoo Kim 한국유전학회 2021 Genes & Genomics Vol.43 No.7
Background Short tandem repeats (STR) typing is an essential analysis method for human identifcation in forensic feld. When DNAs obtained from the feld as evidences are severely degraded or in too small amounts, STR analysis often shows allele drop-out. Objective To improve STR analysis for degraded DNA or trace DNA, reduced-size STR (rSTR) polymerase chain reaction (PCR) system was devised by selecting relatively large-size STR loci. Methods The rSTR PCR system consisted of 8 loci (amelogenin, SE33, CSF1PO, D7S820, D13S317, D2S1338, TPOX, and FGA). The size of PCR product was reduced by designing new primers in the fanking region. The efciency of this system was verifed against existing kits through concordance study, sensitivity study, efciency study, and casework sample study. Results The size of PCR product in the rSTR PCR system was reduced to be less than 322 bp. The amplicon of each locus was reduced by about 100 bp on average. Results of this rSTR PCR system were confrmed using 146 Korean samples and other commercial kits. The rSTR PCR system was capable of analyzing DNA samples with a minimum amount of DNA of 16 pg and a degradation index of 4.215. Conclusion The rSTR PCR system was more efective than other PCR kits for obtaining genetic profles from a small amount of DNA or degraded DNA. The combination of this new system and other commercial kits is more efective than existing systems. This combination is expected to be helpful for the identifcation of unidentifed bodies and skeletal samples.
Jin Kim, Dong,Oh, Joon-Ho,Soo Kim, Han,Soo Kim, Young,Jeong, Manhee,Goo Kang, Chang,Jin Jo, Woo,Choi, Hyojeong,Guk Kim, Jong,Hee Lee, Seung,Ho Ha, Jang TECHNICAL UNIVERSITY OF WROCLAW 2016 MATERIALS SCIENCE -WROCLAW- Vol.34 No.2
<P><B>Abstract</B></P><P>TlBr single crystals grown using the vertical Bridgman-Stockbarger method were characterized for semiconductor based radiation detector applications. It has been shown that the vertical Bridgman-Stockbarger method is effective to grow high-quality single crystalline ingots of TlBr. The TlBr single crystalline sample, which was located 6 cm from the tip of the ingot, exhibited lower impurity concentration, higher crystalline quality, high enough bandgap (>2.7 eV), and higher resistivity (2.5 × 10<SUP>11</SUP>Ω·cm) which enables using the fabricated samples from the middle part of the TlBr ingot for fabricating high performance semiconductor radiation detectors.</P>
MinJeong Kim,SungGon Kim,HyoJeong Kim,HoChan Kim,JiHeh Park,KwangSeok Park,DukKi Lee,WonTan Byun,CheolMin Kim 대한신경정신의학회 2008 PSYCHIATRY INVESTIGATION Vol.5 No.3
Objective-The Penn Alcohol Craving Scale (PACS) is a stronger predictor of subsequent drinking and relapse of alcohol dependence that can be administered more quickly and easily than other craving scales. The goal of this study was to develop the Korean version of the Penn Alcohol Craving Scale (PACS-K). Methods-To examine the psychometric properties of the PACS-K, responses were chosen from 80 patients admitted to a treatment facility for alcohol dependence. Results-The PACS-K possesses good psychometric properties, as assessed by Cronbach’s α estimates (Cronbach’s α=0.91). The test-retest reliability of the PACS-K showed high correlation (p<0.01) when the retest interval was 1 day. When the validity of the PACS-K was investigated using correlation analysis with two other craving scales (the Obsessive Compulsive Drinking Scale (OCDS) and the Visual Analogue Scale (VAS), high correlations were obtained between total PACS scores and total OCDS scores, and between total PACS scores and VAS scores (p<0.01, respectively). Conclusion-The PACS-K is a reliable and valid measure of alcohol cravings, and it could be useful for predicting which individuals are at risk for subsequent relapse.
( Nayoung Kim ),( Dong-hee Lee ),( Woo Seon Choi ),( Eunbi Yi ),( Hyojeong Kim ),( Jung Min Kim ),( Hyung-seung Jin ),( Hun Sik Kim ) 생화학분자생물학회 2021 BMB Reports Vol.54 No.1
Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell anti-tumor specificity and activity. These observations, together with recent advances in the understanding of NK cell activation within the tumor microenvironment, will facilitate the optimal design of NK cell-based therapy against a broad range of cancers and, more desirably, refractory cancers. [BMB Reports 2021; 54(1): 44-58]
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Mira Kim,Jiyoung Jeon,Jongouk Baek,Jaeyul Choi,Eun Ju Park,Jiyeon Song,Hyojeong Bang,Kwee-Hyun Suh,Young Hoon Kim,Jongmin Kim,Doran Kim,민경훈,Kwang-Ok Lee 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2