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Cytolytic Activities of Taxol on Neural Stem Cells
Insoo Lee,HyeEun Han,HyeYoung Lee,Seung U. Kim,TaeUe Kim 대한의생명과학회 2007 Biomedical Science Letters Vol.13 No.4
Stem cells have been the subject of increasing scientific interest because of their utility in numerous biomedical applications. Stem cells are capable of renewing themselves; that is, they can be continuously cultured in an undifferentiated state, giving rise to more specialized cells of the human body. Therefore, stem cells are an important new tools for developing unique, in vitro model systems to test drugs and chemicals and a potential to predict or anticipate toxicity in humans. In the present study, in vitro cultured F3 immortalized human neural stem cell line and in vivo adult Sprague Dawley rats was used to evaluate the cytotoxicity of anticancer drug paclitaxel. In vitro apoptotic activity of paclitaxel was evaluated in F3 cell line by a MTT assay and DAPI test. The cell death was induced with the treatment of 20 nM paclitaxel and chromatin degradation was detected by DAPI staining, which was analyzed by fluorescent microscope. In vivo studies, we also observed nestin immunoreactivity on subventricular zone, which is stem cell rich region in the adult brain of the SD rat. Immunofluorescent staining result shows that pixel intensities of nestin were decreased in a dose dependent manner. These results suggest that paclitaxel is able to induce cytotoxic activity both in F3 neural stem cell line and neural stem cell in SD rat brain.
Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats
Yoon, Insoo,Han, Seungyon,Choi, Young-Hee,Kang, Hee-Eun,Cho, Hyun-Jong,Kim, Jung Sun,Shim, Chang-Koo,Chung, Suk-Jae,Chong, Saeho,Kim, Dae-Duk Informa Healthcare 2012 Xenobiotica Vol.42 No.11
<OL><LI><P>Identifying kinetic determinants of hepatic elimination of drugs would be crucial for better understanding its pharmacokinetics and predicting drug interactions. Present study investigated the kinetics of sinusoidal uptake of docetaxel and its impact on the overall hepatic elimination of docetaxel in rats.</P></LI><LI><P>The non-renal clearance (CL<SUB>NR</SUB>; hepatic elimination) of docetaxel were significantly reduced by co-administration of intravenous rifampicin, a potent inhibitor of organic anion transporting peptides (OATPs; Oatps), at a dose of 20 mg/kg. Docetaxel uptake into isolated rat hepatocytes was found to be temperature/concentration/energy-dependent, saturable, and reduced by Oatps inhibitors (rifampicin and bromosulfophthalein). Moreover, docetaxel uptake into perfused rat liver was significantly reduced in the presence of 10-µM rifampicin. However, docetaxel metabolism in rat hepatic microsome was not affected by rifampicin at less than 50 µM.</P></LI><LI><P>Based on the comparison of intrinsic clearances related to hepatic clearance, it can be suggested that sinusoidal uptake could be the rate-determining process in the overall hepatic elimination of docetaxel in rats.</P></LI></OL>
장인수 ( Insoo Jang ),양창섭 ( Changsop Yang ),선승호 ( Seungho Sun ),정민정 ( Minjeong Jeong ),한창호 ( Changho Han ),황의형 ( Eui-hyoung Hwang ),서형식 ( Hyungsik Seo ) 경락경혈학회 2019 Korean Journal of Acupuncture Vol.36 No.1
Objectives : Carbon dioxide (CO<sub>2</sub>) laser, a high power laser has been used for pain management, dermatology, and surgery and laser acupuncture and moxibustion as well, since it had been oscillated in 1964 at Bell Telephone Laboratories in the US. The purpose of this study is to investigate the history of CO<sub>2</sub> laser acupuncture through reviewing studies published in early stage of laser medicine. Methods : To investigate the early history of CO<sub>2</sub> laser acupuncture, studies were searched in the electronic databases, including PubMed, ScienceDirect, CNKI, Wanfang, J-STAGE, CiNii, KTNP, and OASIS, since 1964. Articles in English, Chinese, Japanese and Korean were included, and there were no limitations in literature types such as reviews, essays, clinical trials, animal experiments and veterinary research. Results : We found that the first CO<sub>2</sub> laser application to acupoints was done by a research team in Shanghai in 1976. They used CO<sub>2</sub> laser for acupuncture treatment and it was also the first laser acupuncture treatment in China. Since the first case report of CO<sub>2</sub> laser for leukopenia, it has been applied to various diseases in China, Korea, Japan and other western countries. It has been widely applied in the fields of dentistry and veterinary medicine, as well as clinical applications. Conclusions : Not only CO<sub>2</sub> laser can be used as laser acupuncture by stimulating the acupoints and meridians, but also can produce moxibustion effect by using heat stimulus. Therefore, it is expected that it will be used in various clinical fields in the future.
신경망과 다속성 의사결정 기법을 이용한 일정관리 휴리스틱의 선택
황인수,한재민 한국경영과학회 1996 經營 科學 Vol.13 No.3
This paper presents an approach for classifying scheduling problems and selecting a heuristic rule to yield best solution in terms of certain performance measure(s). Classification parameters are employed from previous studies on job shop scheduling and project scheduling. Neural network is used for leaning and estimating the performances of heuristic rules. In addition, multi-criteria decision making techniques are employed to combine the preferences for each performance measure and heuristic rule for the problems with multi-objectives.
금속판재의 등2축 인장시 X-Ray Diffraction Pattern의 변화
전윤한,김인수 金烏工科大學校 1993 論文集 Vol.14 No.-
This paper was studied the variations of x-ray diffraction pattern and texture under equibiaxial stretching in various sheet metals. After the equibiaxial stretching, (200) plane is developed well in FCC structure materials, but is not changed in BCC structure material, and all materials having preferred oriention have changed to planar isotropic sheets.