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편영식(Y. S. Pyoun),박정현(J. H. Park),이건범(K. B. Lee),요꼬이 요시유끼(Y. Yokoi),여진욱(J. W. Yeo),정일용(I. Y. Jeong),안건준(K. J. Ahn),곽철훈(C. H. Kwak) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
In order to improve the international competitiveness of ferrule industry, the core technology of the<br/> second stage for ferrule grinding system is under developing. A high speed (10,000RPM) and high<br/> precision spindle system(Radial Runout 0.2 micrometer) bearing more cutting torque and force is<br/> designed considering the limitation of cost and size, the effect of heat, and various work-piece<br/> materials. A CAE software for machine elements and general machine system is used for preliminary<br/> evaluation and selection of design parameters. A dedicated program for the analysis of spindle system<br/> is used for final evaluation and selection of design parameter. The process how to evaluate and select<br/> using such tools are presented.
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
Yamada, Y.,Nishida, T.,Ichihara, S.,Sawabe, M.,Fuku, N.,Nishigaki, Y.,Aoyagi, Y.,Tanaka, M.,Fujiwara, Y.,Yoshida, H.,Shinkai, S.,Satoh, K.,Kato, K.,Fujimaki, T.,Yokoi, K.,Oguri, M.,Yoshida, T.,Watanab Elsevier Scientific Publ. Co 2011 Atherosclerosis Vol.215 No.1
Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0x10<SUP>-7</SUP>) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.