集團驅蟲에 依한 蛔蟲, 十二指腸蟲(鉤蟲)의 撲滅에 關한 野外實驗(第一報) : (附) 메탄까스 發生用 糞尿탱크內 蛔蟲卵·鉤蟲卵 抵抗力 實驗 Addendum:Resistance of Ascaris and Hookworm Eggs in Methane Gas Producing Tank

蘇鎭琸,盧全熙,崔吉俊,嚴英燮,李在興 최신의학사 1968 最新醫學 Vol.11 No.3

The authors examined the prevalence of ascaris and hookworm infection in rural villages: Ije and Yongyon, albong-myun, Iksan - gun,Chollapukdo, Korea. The positive cases treated with appropriate anthelmintics iperazine adipate and Bephenium hydroxynaphthoate etc.). Additionally, the resistance of ascaris and hook- eggs in. methane gas producing tanks which were provided in I je-village were examined. The first year U are summarized as follows: The incidence of ascaris in Ije-village was 63.0% (184 out of 291 examined) before treatment and 70.5% titer 10 months, but the worm burden (E.P.G./gm feces) was 26,731 before treatment in average and 6,018 n' months later. -Yongyon, the incidence and worm burden in the same period changed from 77.1% (108 out of 140 exined) to 63.0% an& 22,091/E.P.G. to 4,709/E.P.G. Incidence of hookworm before treatment was 36(12.4%)out of 291 examined in Ije village, and 29(20.7/) t of. 140 examined 'in Yongyon village. After the treatment, the positives were only two in both villages pectively. On the third examination after the second treatment, the remaining two positives became gative. More than 15 % of ascaris eggs in methane gas producing tanks surived after 5 weeks during summer seasen, and hookworm eggs survived for 12 days which were the terminal date in the study.

Prevalences of Clonorchiasis and Metagonimiasis along Rivers in Jeonra-Nam-Do, Korea

Soh, C.T.,Lee, K.T.,Cho, K.M.,Ahn, Y.K.,Kim, S.J.,Chung, P.R.,Im, K.I.,Min, D.Y.,Lee, J.H.,Chang, J.K. INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1976 YONSEI REPORTS ON TROPICAL MEDICINE Vol.7 No.1

전라남도 영산강 및 섬진강유역 주민의 간디스토마와 요꼬가와흡충 감염율의 조사 및 이들 패류매개성 기생충의 제1, 제2 중간숙주를 조사한 바 그 성적을 요약하면 다음과 같다(조사기간: 1975년 8,9월, 1976년 7,8월). 영산강 유역 영산강을 상류(YU), 중류(YM), 하류(YD)로 삼분하여 10개 표본지역을 선정, 조사하였다(표 1 참조). 상류는 광산군 송정읍의 상부지역으로 장성군과 담양군이 이에 해당되며 중류는 송정읍과 나주군 영산포읍 사이의 지역으로 광산군 일부와 나주군이 이에 해당되며 하류는 영산포읍이하의 나주군 일부와 함평군이 이에 해당된다. 1. 주민의 감열율 : 상류 3개지역, 중류 1개지역 그리고 하류 2개지역 등 6개지역 주민 359명을 대상으로 조사하였다. 상류지역의 간디스토마 감염율은 29.9%(69/231), 중류 38.5%(20/52), 하류 21.1%(16/76)이었다. 전체적으로는 29.2%(105/359)의 감염율을 나타내었으며 남자는 39.3%(79/201), 여자 15.4%(21/136)로 전자가 2.5배 이상의 감염상을 보였다. 2. 제 1 중간숙주 : 간디스토마의 제 1 중간숙주인 왜우렁(Parafossarulus manchouricus)의 조사는 상류 2개지역, 중류 4개지역, 하류 1개지역등 7개지역에서 채집한 980개를 검사하였으며 그 중 11개(1.1%)에서 간디스토마셀카리아를 검출하였다. 지역별로는 상류 1.8%(6/333), 중류 0.9%(5/553)가 양성이었으나 하류지역의 94개에서는 모두 음성이었다. 요꼬가와흡충의 제 1 중간숙주인 다슬기(Semisulcospira libertina)를 상, 중, 하류의 각 1개지역씩 3개지역에서 모두 179개를 채집하여 검사하였으나. 요꼬가와흡충 또는 페디스토마의 셀카리아는 검출할 수 없었다. 3. 제 2 중간숙주 : 전지역에서 9종의 담수어 263마리를 포획하여 검사한바 간디스토마메타셀카리아의 양성율은 참붕어에서 62.9%(22/35), 피리 5.7%(3/53), 납지리류 21.9%(7/32), 돌고기 17.6%(3/17), 그리고 끄리에서 14.3%(1/7)이었으나 붕어, 모래무지, 버들붕어 및 꺽지 등에서는 검출할 수 없었다. 요꼬가와흡충의 제2중간숙주인 은어는 채집 또는 포획할 수 없었다. 섬진강유역 전라남도 관내의 섬진강을 상, 중, 하류로 구분하여 각 유역별로 2개지역씩 선정, 6개지역에서 조사하였다(표 1 참조). Soh, C.T. et al. 표 1. 영산강 및 섬진강 유역 조사대상 지역 =================================================================================== 영산강 유역 ∥ 섬진강 유역 ------------------------------------------∥--------------------------------------- 지 역 *조사내용 ∥ 지 역 *조사내용 ------------------------------------------∥--------------------------------------- 상류 1. 장성군 황룡면 황룡리 P. 1.2. ∥상류 1. 곡성군 곡성면 동산리 P. 1. 2. 담양군 봉산면 삼지리 P. 1.2. ∥ 2. 곡성군 곡성면 석곡리 P. 1.2. 3. 담양군 금성면 금월리 P. ∥ 중류 1. 나주군 영산포읍 1. ∥중류 1. 구례군 구례읍 신월리 P. 1.2. 2. 나주군 산포면 산제리 1.2. ∥ 2. 곡성군 곡성면 압록리 2. 3. 나주군 남평면 남평리 1.2. ∥ 4. 광산군 동곡면 복용리 P. 1.2. ∥ 하류 1. 함평군 엄다면 학교리 P. 1.2. ∥하류 1. 광양군 다압면 신원리 2. 2. 나주군 다시면 신풍리 P. ∥ 2. 광양군 다압면 고사리 P. 1.2. 3. 나주군 문평면 용문리 2. ∥ ------------------------------------------------------------------------------------ *(주) P: 주민 감염율조사. 1: 제1 중간숙주조사. 2: 제2 중간 숙주조사. 상류는 전라북도와 전라남도의 경계선 이하에서 곡성군 곡성읍 상부와 섬진강의 지류인 보성강유역이 해당되며 중류지역은 섬진강과 보성강이 합류되는 곳에서부터 광양군 다압면의 상류지역으로 곡성군 일부와 구례군이 이에 해당되며 하류는 다압면이하로 광양군이 해당된다. 1. 주민의 감염율 : 상류 2개지역, 중하류 각 1개지역 등 4개지역에서 296명을 대상으로 조사하였던바 전체적으로 간디스토마 충란양성자는 21명(7.1%)인데 비해 요꼬가와흡충충란 양성자는 123명(41.6%)이었으며 지역별 간디스토마의 감염율은 상류 5.6%(7/124), 중류 7.4%(6/81), 하류 8.8%(8/91)이었으며 요꼬가와흡충은 상류29.0%(36/124), 중류 58.0%(47/81), 하류 44.0%(40/91)이었다. 요꼬가와흡충충란양성자의 경우 남자는 55.5%(81/146)로 여자의 28.0%(42/150)보다 약 2배 가량 높은 감염율을 보였다. 요꼬가와흡충충란은 전 연령층에서 검출되었으나 간디스토마는 19세이하에서는 검출되지 않았다. 한편 두 흡충의 혼합감염율은 5.7%(17/296)이었다. 2. 제 1 중간숙주 : 왜우렁은 중류지방에서만 채집되었으나 간디스토마셀카리아를 검출치 못하였고 다슬기는 모두 663개를 채집하여 검사한바 62개(9.4%)에서 요꼬가와흡충셀카리아를 검출하였다. 이를 지역별로 보면 상류 9.2%(39/427), 중류 4.8%(3/62), 하류 11.5%(20/174)의 양성율을 보였다. 3. 제 2 중간숙주 : 전지역에서 10종의 담수어 175마리를 포획하여 검사하였으나 간디스토마메타셀카리아는 검출치 못 하였다. 그러나 그중 은어에서는 35마리 전부에서 요꼬가와흡충메타셀카리아를 검출하였다. 이상의 성적으로 보아 영산강유역은 간디스토마의 만연지역이나 요꼬가와흡충의 만연은 볼 수 없었다. 그러나 섬진강유역은 요꼬가와흡충 및 간디스토마의 만연지역이라고 볼 수 있으나 이 지역의 간디스토마감염이 토착성인지는 더 추구되어야 할 과제라고 본다.

POSTERS / PW-035 : CAPSAICIN INDUCES APOPTOSIS IN RAS - TRANSFORMED HUMAN BREAST EPITHELIAL CELLS VIA ACTIVATION OF C-JUN N-TERMINAL PROTEIN KINASE

(H . J . Kang),(M . S . Kim),(Y . Soh),(Y . J . Surh),(H . R . C . Kim),(A . Moon) 한국생화학분자생물학회 (구 한국생화학회) 1999 6th IUBMB SEOUL CONFERENCE Vol.- No.-

Constitutive expression of a fungus-inducible carboxylesterase improves disease resistance in transgenic pepper plants

Ko, M.,Cho, J. H.,Seo, H. H.,Lee, H. H.,Kang, H. Y.,Nguyen, T. S.,Soh, H. C.,Kim, Y. S.,Kim, J. I. Springer Science + Business Media 2016 Planta Vol.244 No.2

<P>Resistance against anthracnose fungi was enhanced in transgenic pepper plants that accumulated high levels of a carboxylesterase, PepEST in anthracnose-susceptible fruits, with a concurrent induction of antioxidant enzymes and SA-dependent PR proteins. A pepper esterase gene (PepEST) is highly expressed during the incompatible interaction between ripe fruits of pepper (Capsicum annuum L.) and a hemibiotrophic anthracnose fungus (Colletotrichum gloeosporioides). In this study, we found that exogenous application of recombinant PepEST protein on the surface of the unripe pepper fruits led to a potentiated state for disease resistance in the fruits, including generation of hydrogen peroxide and expression of pathogenesis-related (PR) genes that encode mostly small proteins with antimicrobial activity. To elucidate the role of PepEST in plant defense, we further developed transgenic pepper plants overexpressing PepEST under the control of CaMV 35S promoter. Molecular analysis confirmed the establishment of three independent transgenic lines carrying single copy of transgenes. The level of PepEST protein was estimated to be approximately 0.002 % of total soluble protein in transgenic fruits. In response to the anthracnose fungus, the transgenic fruits displayed higher expression of PR genes, PR3, PR5, PR10, and PepThi, than non-transgenic control fruits did. Moreover, immunolocalization results showed concurrent localization of ascorbate peroxidase (APX) and PR3 proteins, along with the PepEST protein, in the infected region of transgenic fruits. Disease rate analysis revealed significantly low occurrence of anthracnose disease in the transgenic fruits, approximately 30 % of that in non-transgenic fruits. Furthermore, the transgenic plants also exhibited resistance against C. acutatum and C. coccodes. Collectively, our results suggest that overexpression of PepEST in pepper confers enhanced resistance against the anthracnose fungi by activating the defense signaling pathways.</P>

Plasma-Enhanced Passivation of a Cu/Ti Bilayer Gate Electrode for an Amorphous Silicon Thin-Film Transistor

T. K. Hong,H. J. Park,D. M. Han,K. H. Jeong,C. S. Kim,C. O. Jeong,J. H. Lee,D. H. Kim,이은구,H. S. Soh,이재갑 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5

Self-passivated copper as a gate electrode in the form of TiOxNy/Cu/Ti/SiO2 has been obtained by exposing Cu/Ti/SiO2 to mixed of N2/H2 plasma at a low temperature of 300℃. The use of the plasma provides an additional surface heating source, allowing the Ti atoms to outdiffuse to the Cu surface at 300℃ and to react to form a passivation layer on the surface. The H2 plasma transforms the Ti layer into titanium hydride, which effectively inhibits the Cu-Ti reaction and serves as a diffusion barrier against Cu metallization. The TiNxOy/Cu/Ti/SiO2 multilayer formed at the low temperature can be used as a gate electrode in thin-film transistor liquid crystal displays (TFT-LCDs) and exhibits a gate voltage swing of 0.943 V/decade, a threshold voltage of -1.07 V, a mobility of 0.669 cm2/V-s and a Ion/Ioff ratio of 8.18×106. Consequently, this low- temperature plasma processing will allow a reliable passivated gate electrode, which can be utilized in low-temperature amorphous Si thin-film transistor liquid crystal displays, to be formed.

Production of Interferon Tau and TGF-β by Porcine Embryos

S. Y. Baek,H. C. Soh,E. S. Cho,T. J. Choi,Y. M. Kim,S. J. Kang,K. H. Cho,H. J. Chung 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2

In pigs, expression and amounts of biologically active interferon tau (IFNT) and transforming growth factor-β (TGF-β) at the conceptus-maternal interface increase significantly as conceptuses elongate and begin the implantation process. Epidermal growth factor (EGF) acts through EGF receptor (EGFR) present in the blastocyst seems to regulate embryonic production of IFNT. To understand the mechanisms regulating the interaction between the hatched blastocyst and maternal uterine environment, the production of IFNT and TGF-β were investigated. Hatched pig blastocysts (days 7~10) were cultured and exposed to EGF (0, 1, 10 and 100 ng/mL) for 24, 48 and 72 h. Protein concentrations of IFNT in the cultured media were determined by commercial enzyme-linked immunosorbent assay (ELISA) kit. Epidermal growth factor (10 and 100 ng/mL) increased embryonic production of IFNT and TGF-β production by hatched blastocysts. The above results suggest that epidermal growth factor produced by epithelial cell stimulates the production of IFNT by pig trophoblasts. The capacity of conceptus to increase IFNT and TGF-β production in response to EGF stimulation may be important for the establishment of pregnancy in pig.

集團驅蟲에 依한 蛔蟲十二指 腸蟲(구충) 撲滅에 關한 野外實驗(第二報) : 冬節을 利用한 구충의 集團驅蟲效果 Followup studies for years after the treatment of hookworm in winter season

蘇鎭琸,李在興,李俊英,金和濬,千炯福 최신의학사 1969 最新醫學 Vol.12 No.10

Mass treatment of hookworm infection was practised during winter season, (February and December, 1967) in the lie-village, Palbong, Chollapukdo, Korea. The followings are the supplementary results after followup studies since the previous report in 1968.: 1. Total 36 hookworm infected cases out of 291 examined (inhabitants 362) were treated by repeated administration of anthelminthics, and complete egg negative were fulfiled on December, 1967. 2. In August of 1968, 205 people including the former 36 positives were examined for hookworm :infection. Among them, two were positive; one was new case and another one was the reinfected case. A Both of those were treated with appropriate anthelminthics. 3. In March of 1969, stool examination was done with the number of 197 people including all former Cases. One out of three positives was the reinfected case. It was suggested that the mass-treatment of hookworm infection during cold months might be effective !;to eliminate the parasite from. one community, but full cooperation of the villagers would be needed to ach complete success.

數種化學製劑에 依한 農村糞尿分離式便所內의 蛔蟲卵 살란效果

盧庸熙,金鍾煥,蘇鎭琸 최신의학사 1968 最新醫學 Vol.11 No.4

Authors carried out an examination of the ovicidal effect of sodium nitrite(NaNO2), thiabendazole and alcium cyanide(CaCN2) against ascaris eggs in nightsoil at rural village. The combination of sodium nitrite (0.1%) and calcium superphosphate (6%) in feces effected 91.8^-100 per cent of destruction of ascaris eggs in the nightsoil tank. Thiabendazole destroyed the ascaris eggs 94.395.1 per cent at the terminal concentration of 0.01 per cent in nightsoil tank. 3. Calcium cyanide(CaCN2) did not destroy the ascaris eggs in nightsoil at the applicable concentration of 0.3 per. cent.

2-Dehydroemetine hydrochloride(Ro 1-9334)에 依한 肺吸蟲症 臨床治療 成績

임영찬,柳浩濬,金應瑞,金元一,李炫,朴柄宰,蘇鎭卓 中央醫學社 1964 中央醫學 Vol.6 No.2

44 cases of paragonimiasis were admitted in 121 Army Hospital for the clinical trial with the drug, dehydroemetine hydrochloride. Dehydroenietine hydrochloride was administered to 19 cases with the doses of 1 mg/kg of body weight/day for 10 days, and second course of 13 day administration was followed after 12 day rest. The remain of cases were applied as control group for emetine-HCI, astiban, and 5% glucose solution. The result of the trial are summarized as follows; 1) 15 out of 19 cases showed decrease of E.P.D. (egg per day) after the second course. 3 converted. to egg negative and 5 showed complete disappearance of blood sputum. 2) Three cases showed radiological improvement in X-ray picture. 3) Blood pressure, red cell sedimentation rate, and white blood cell count became worse at the beginning of the administration of the drug in several cases with short duration, then continued to be with in the normal range of their values until after the second course. 4) Electrocardiographic changes were very slight in several cases, but recovered to normal in 1-'2 weeks after the administration of the second course. 5) Systemic side effects were practically absent. 6) No improvement of symptoms was observed in 2 cases administered with astiban, 3 cases with emetine-HCI, and 20 cases with 5% glucose as control.

조직 배양에 의한 약용 식물 자원의 생약학적 연구(Ⅴ) : 시호의 조직배양에 있어서 2, 4-D 와 phenylalanine의 영향에 따른 saikosaponin분석 The saikosaponin contents and the growth effects by 2, 4-D & phenyalanin in tissue cultured Bupleurum falcatum L.

원봉필,강신복,유태무,김형수,성락선,이춘길,소웅영,신승원 국립보건연구원 1994 국립보건원보 Vol.31 No.2