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Ecogenetic and Population Genetic Studies on Alcohol Sensitivity
Goedde, H Werner 한국유전학회 1983 Genes & Genomics Vol.5 No.3
Concerning Population Genetic Research many protein polymorphisms, especially those of enzymes, are of great importance. Most of the so-called genetic traits are of general interest in regard to the deferring gene frequencies in various racial groups. Often, isozymes or protein variants of certain metabolisms can be connected to inborn errors of metabolism or genetic defects, which may be observed only in distinct populations - and in certain individuals. The connection of such traits to metabolite diseases is of considerable importance. Alcohol is a drug - or generally spoken an environmental substance or xenobiotic. Those are often potentially toxic chemicals which. may cause damage to certain individuals - but not to others. In this concern the study of genetic aspects of ecology is called ecogenetics. Recent studies on the polymorphism of alcohol dehydrogenase and aldehyde dehydrogenase have received considerable attention to genetic variants of these enzymes in concern to the metabolism and toxic effects of ethanol and especially of acetaldehyde. The development of highly sensitive methods enabled us to study the isozymes in various organ extracts, skin, fibroblasts and hair root lysates. The results of family and population genetic studies in different racial groups lead to our hypothesis which explains now the observed high incidence of alcohol sensitivity among Mongoloid populations. The fact that genetics may be involved in regulating individual sensitivity to alcohol suggests that biological factors might partially answer the question why many people drink very little alcohol - especially in Orientals. The biochemical genetic basis of a predisposition for - or protection against alcohol related problems will be discussed. A better knowledge concerning these problems may help in more effective and therapeutic actions in preventive medicine.
한국인 혈청 paraoxonase 의 저활성 동형 접합체 빈도
Goedde, H Werner,Benkmann, Heide G,백용균 한국유전학회 1988 Genes & Genomics Vol.10 No.4
Serum paraoxonase activity was measured in five population groups in South Korea. Assuming a two allele model, the phenotypic distributions of the enzyme activity were very similar. The frequencies of homozygous low activity groups ranged from 13.5% to 19.7% across the population groups.
Frquency of Aldehyde Dehydrogenase 1 Isozyme Deficiency in Koreans : A Pilot Study
백용균 ( H . Werner Goedde,Dharam Pal Agarwal,Yong Kyun Paik ) 한국유전학회 1983 Genes & Genomics Vol.5 No.3
ALDH I isozyme deficiency was studied in a Korean sample. Out of 75 subject, 26.7% showed a lack of ALDH 1 isozyme.
한국인의 PGM1 , PI , PLG 및 POX 다형현상
백용균,Goedde, H Werner,조율희 한국유전학회 1988 Genes & Genomics Vol.10 No.3
Phenotypes and gene frequencies among 364 Koreans were studied for three serum protein polymorphisms (PLG, Pi with subtypes and POX) and one red cell enzyme polymorphism (PGM_1 with subtypes). Pi and PGM_1 subtyping was conducted by polyacrylamide gel IEF, PLG typing by immunofixation after IEF, and POX activity measurement by direct spectrophotometry. The allele frequencies obtained are as follows: Pi*M1=0.7665, M2=0.1690, M3=0.0577, P=0.0041, G=0.0014, V=0.0014; PLG*1=0.9835, 2=0.0027, A=0.0014, B=0.0124; PGM_1*a1=0.7060, a2=0.1580, a3=0.0948, a4=0.0330, 6=0.0014, 8=0.0069. The frequency distribution of POX activity in this study appears to show a unimodality, giving a mean activity of 221.01 U/1. The results are discussed in relation to earlier known estimates in Koreans and those obtained in other geographic populations.
김인규,백용균,Goedde, H Werner,Benkmann, Heide G,조율희 한국유전학회 1988 Genes & Genomics Vol.10 No.4
Serum cholinesterase and N-acetyltransferase polymorphisms were investigated in unrelated individuals from different parts of South Korea. The frequency of the allele(Ac*S) controlling the slow acetylation was ca. 0.561; no atypical variants of normal serum cholinesterase which fail to hydrolyse suxamethonium could be found. The phenotype distribution of the two pharmacogenetic markers in different populations of the world is described.
유전자 빈도의 컴퓨터 최우 추정 : 한국인의 Rh 및 MNSs 유전자계 Rh and MNSs Systems in a Korean Population
Paik, Yong Kyun,Goedde, H Werner,Benkmann, Heide G,Kim, Baek Sop,Choi, Soo Kyung 한국유전학회 1989 Genes & Genomics Vol.11 No.2
Gene and phenotype frequencies for the Rh and MNSs blood group systems were studied in a Korean population group. Gene complex frequencies were calculated by ML procedures programmed for the PASCAL. This population was characterized by a relatively high frequency of CDe as well as high frequencies of Ms and Ns. The results are discussed in relation to other geographic populations.
한국인의 δ - aminolevulinate dehydrase 다형현상
Lee, Chung Choo,H Werner Goedde,Paik, Yong Kyu,Heide G Benkmann 한국유전학회 1988 Genes & Genomics Vol.10 No.3
δ-aminolevulinic acid dehydrase phenotypes have been estimated in five population groups of South Korea. No significant differences of gene frequencies could be observed. The distribution of phenotypes in different populations of the world is discussed.