아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

췌장의 가성낭종 파열에 의한 하부 위장관 출혈 1예

장성종,김병수,부귀범,김동규,박찬국,김만우,김정용,박상헌 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Pancreatic pseudocysts usually develop as a complication of acute pancreatitis or repeated attacks of chronic pancreatitis. Pseudocysts may also develop as a result of traumatic injuries or neoplasms. An uncommon complication is massive hemorrhage inside the pancreatic pseudocyst. The exact mechanism of hemorrhage is unknown. Enzymatic digestion, pressure erosion from the cyst mass or a combination of these processes may play an important role. Gastrointestinal hemorrhage associated with a pancreatic pseudocyst can occur in 10 percent of cases. When hemorrhage occurs because of erosion into a blood vessel involved in the pseudocyst, surgery is indicated since the episodes of hemorrhage are often severe and may even be fatal. When there is colonic involvement, various complications may occur. The most dangerous one is spontaneous rupture into the colon, which requires immediate surgical treatment because of high incidence of fulminating sepsis or massive hemorrhage. We examined a sixty eight-year-old man complaining of hematochezia and dizziness, and reported that it was a case of massive lower gastrointestinal hemorrhage caused by pseudocyst of the pancreas ruptured into the colon associated with chronic pancreatitis. On operative findings, the peripancreatic fatty tissue had severe adhesions to transverse colon and tail portion of pancreas, where the pseudocyst had formed. A distal pancreatectomy, splenectomy and resection of transverse colon were performed. By microscopic examination, hemorrhagic necrosis and inflammatory change were observed in the pancreas specimen. The tail portion of pancreas had a 6×6 cm sized cystic mass and was proven to be a pseudocyst with no epithelial lining.

Cu(Ⅱ), Co(Ⅱ), Ni(Ⅱ)와 Dithiooxamide의 착물형성 Mechanism과 반응 속도에 관한 연구

장진규,이동선 동의공업대학 1999 論文集 Vol.25 No.1

The kinetics of the reaction of Dithiooxamide with Nickel(D), Cobalt(n) and Copper(Ⅱ) to form the mono complexes have been studied at 25℃ and 1.0M ionic strength by conventional and stopped-flow spectrophotometry. The Semi aci form of Dithiooxamide does not react with metal ions, while the aci form reacts by parallel acid-independent and inverse-acid paths. The rate constant for the reaction of HA, the undissociated aci form, with Ni²+, is 4.6, respectively. and the rate constants for the reaction of A?? , the aciate ion, with Ni²+, Co²+ and Cu²+ are 2.7 x 10⁴, ??5.2x10⁴and 5.1 x 106 M??· sec??, respectively. The rate constants, K?? and Ks, for the Semi aci - aci tautomerism of the Dithiooxamide defined by Semi aci ?? aci (K??: forward, KS: revers) are 9.2 x 10??and 2.3 sec??, respectively. The kinetics of the complex formation reactions are discussed in terms of a sterically controlled substitution mechanism and in terms of a mechanism in which proton loss from the ligand is an important rate-determining factor. The values of the equilibrium constants, K₁, for the reaction, Mⁿ+ + HA?? MA(??) + H+ where HA represents the undissociated Dithiooxamide, were found to be 9.6 x 10??, 2.8 x 10??and 0.28 at 25℃ and 1.0M ionic strength for the Nickel(Ⅱ), Cobalt(Ⅱ) and Copper(Ⅱ) system, respectively. (원문을 참조하세요)

AR 모델 및 LSQ 기반 변류기 2차 전류 복원 기법

張洙榮,李東圭,姜相熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

The current flowing though a power line is measured by a current transformer (CT). Since a CT is a kind of transformer, saturation of magnetic flux in the core may occur when a large primary current flows. This saturation makes the secondary current of a CT distorted and causes problems in the protection point of view. Because of the current distortion, a protection relay cannot collect the correct information showing how the primary power system changed. Consequently, the current distortion may cause the mal-operation or operation time delay of protective relay. In this project, an algorithm based on AR model and LSQ is proposed to compensate the saturated CT secondary currents. Various test results indicate that the proposed algorithm can accurately compensate a severely distorted secondary current and is not affected by remanence. This paper concludes by describing the hardware implementation of the algorithm based on a digital signal processor

종이 코팅용 아크릴 에멀젼의 중합물성에 관한 연구(Ⅰ)

장진규,이진우,이동선 동의공업대학 1998 論文集 Vol.24 No.1

Emulsion polymerization of acrylic ester comonomers has been conducted to investigate the effect of anionic-nonionic emulsifier mixture, concentration of initiator and eletrolyte on the size and size distribution of emulsion polymer particles for the purpose of application in the paper coating, It was found that the emulsifier mixture consisting of sodium dodecylbenzene sulfonate and nonylphenoxy po1y(ethyleneoxy)ethanol with high combined HLB value in the range of 14.36∼14.91 gave stable acrylic emulsion with high conversion. The effects of emulsifier, initiator, and electrolyte concentration on the polymer particle size were studied, It was found that acryl emulsion of average particle size (about 0.2 micron with broad size distribution) have desirable moisture vapor transmittance resistance.

수분산성 에멀젼의 고형분 향상에 관한 연구

장진규,이동선,최진호 동의공업대학 1999 論文集 Vol.25 No.1

Acrylonitrile butadiene rubber (NBR) latex was agglomerated by highly carboxylated agglomerating agent, which contained carboxyl groups in the shell polymer. The effects of different parameters upon particle size of NBR latex, agglomerated NBR latex and agglomerating agent were studied, namely, amount of emulsifier, amount of initiator, agglomerated process, amount of agglomerating agent. It was found that water based polymer of agglomerated NBR latex have desirable high solid content.

자궁탈의 임상적 고찰

김동원,노형균,안태규,최상준,송창훈,정혁 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

The purpose of this study was to evaluate clinical aspects of prolape uteri. This clinical and statistical study was attempted to analyze 369 cases of uterine prolapse(328 cases -operated, the other cases - not operated) from Jan. 1994 to Dec. 1998 at the Department of Obstetrics and Gynecology, Chosun University Hospital. The results were as follows. 1. The incidences of uterine prolapse was 0.62% of the total admitted gynecologic patients during the study period. 2. Age distribution at the time of operation showed that 184 cases(25.6%) were 60 to 65 years of age, and 62 cases(18.2%) were 56 to 60 years of age. 3. Age distribution at the time of development of prolapse uteri showed that 134 cases(36.3%) were 21 to 30 years of age, 126 cases(34.1%) were 31 to 40 years of age. 4. 228 cases(61.7%) were those who had suffered from uterine prolapse for more 11 years and the mean durations were 15.6 years. 5. The degree of prolapse uteri showed that 281 cases(76.1%) were 3rd degree and 61 cases(16.5%) were 2nd degree. 6. The parity showed that 297 cases(80.2%) were over 4 times and 2 cases(0.27%) was nullipara. 7. The delivery place was at home in 318 cases(86.1%) and in hospital in 51 cases(13.9%). 8. The main symptoms comprised prolapse in 311 cases(84.2%), urinary frequency in 259 cases(70.1%), and bearing down sensation in 242 cases (65.8%). 9. An operation in 328 cases was carried out of 369 cases of prolapse uteri, 301 cases were treated by the vaginal hysterectomy with either anterior &osterior repair or posterior repair, 23 cases were treated by anterior &osterior repair. 10. The postoperative complications were urinary tract infection in 7 cases(2.1%), urinary retention in 4 cases(1.2%), vaginal vault prolapse in 2 cases(0.6%). 11. The indwelling foley catheter was kept for 7 days in 279 cases and the average postoperative hospitalization was around 9 days. 12. The postoperative pathologic findings were chronic cervicitis in 211 cases(67.8%), squamous metaplasia of the cervical gland in 98 cases(31.5%), adenomyosis in 69 cases, leiomyoma in 47 cases, and dysplasia of cervix, cervical polyp, endometrial polyp were also resulted. In conclusion, clinical features of uterine prolapse were studied. The clinical evaluation of uterine prolapse include age, parity, degree of prolapse, delivery site, age of onset, symptomatology, type of operation, complications, the results of histopathological examinations. Further study is necessary before these aspects can be implicated in the clinical evaluation of uterine prolapse.

두개강내 해면상혈관종의 임상양상 및 수술적 치료의 효용

오창완,정영섭,김동규,백선하,조병규,왕규창,한대희 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.6

紫金錠의 抗腫瘍效能에 對한 考察

朴一東,孫彰奎,趙鍾寬 대전대학교 한의학연구소 2002 혜화의학회지 Vol.10 No.2

In the literal study of anti-tumor effects of Jakeumjung, the results were as follows. 1.Jakeumjung is a traditional oriental medical prescription which is composed of Cremastare appeniculatae tuber, Euphorbiae pekinensis radix, Toosendan fructus, Chinensis galla, Moschus, Realgar and Cinnabaris. 2.Jakeumjung is applied to patients by administering or external application. When it is administered for patients, pertinent dose is 0.6∼1.5g twice or three times per one day. When it is applied by external application, we melt it by water or vinegar and apply it to patients. 3.Effects of Jakeumjung are expelling toxin and pestilence, counteracting pathogen and reliving stagnation, detumescence and stopping pain. So it is used for detoxification from ancient. In recent, it is often used for cancer such as breast cancer, pancreatic cancer, epigastric cancer, acute leukemia, lymphoma, thymus cancer and skin cancer. 4.From the various experiments, Jakeumjung has been proved to have antifungal and antitumor effects. It inhibits and kills L7212,L1210 cells of leukemia. Especially, it acts in S stage of cell period. 5.Jakeumjung includes mineral medicines such as Realgar, Cinnabaris. So if we execute progressive study for anticancer effects and safety, the boundary of oriental medicine of using mineral medicines for cancer therapy will magnify in the future.

광섬유 Fabry-Perot 간섭형 전류 및 전압센서 시스템의 제작

박동수,김명규,김창원,이정희,손병기 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1

Although the conventional current transformers(CTs) and the potential transformers(PTs) have been used in the power system, new method is demanded which can measure with safty, EMI(electro-magnetic interference)-free. Over the last few years, variours kinds of optical measurement systems have been studied. The optical CTs and PTs systems, however, are very complicated and large, and hence the systems have a difficulty to maintain and repair. A new type fiber optic voltage and current transducers were fabricated by using fiber optic Fabry-Perot interferometer and PZT. A simple optical signal processing circuits and its PC interface circuits were also designed.