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RISS 인기검색어
- 검색키워드
- 저자 : Gyoseon Yeom(염교선) (검색결과 2 건)
- 무료
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- 유료
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In-vitro study of hemorheological characteristics of erythrocytes incubated in glucose medium
Gyoseon Yeom(염교선),Yunhee Ku(구윤희),Sehyun Shin(신세현),Jangsoo Suh(서장수) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Deformability of red blood cells (RBCs) plays an important role in microvascular flow system and decreased RBC deformability is frequently observed in diabetic patients. The object of this study was to examine the effect of elevated in vitro glucose concentrations on hemorheological properties of human erythrocytes. Groups were exposed to 0 ~ 5% glucose concentrations. The incubation time effect of any changes was also evaluated. Hemolysis of erythrocytes was evaluated using spectrophotometric methods. Erythrocyte deformability was assessed using a new microfluidic ektacytometry (RheoScan-D 200) and erythrocyte aggregation was measured with LORCA. We found that RBC deformability was significantly decreased with increasing the glucose concentration in the medium. Also the RBC aggregation was decreased in normal plasma condition. Our findings show that oxidative effect of glucose on erythrocytes strongly depends on concentration and incubation time.
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Rheolocial reconsideration of blood viscosity
Yunhee Ku(구윤희),Gyoseon Yeom(염교선),Sehyun Shin(신세현),Jangsoo Suh(서장수) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Deformability of red blood cells(RBCs) plays an important role in microvascular flow system and impaired RBC deformability causes significant increase blood viscosity. The present study investigated the correlation of RBC rheological properties and blood viscosity. When RBC were heated at 49℃, the deformability was significantly reduced compared to that of control but the corresponding suspension viscosity was almost the same as the normal blood viscosity. This unexpected result was further studied with morphology of RBCs and tank-treading capability. It is found that heat treatment altered the geometry of RBC including cell shape and size, which result in reduction of blood viscosity. Conclusively, the effect of reduced RBC size suppresses the effect of decreased deformability on blood viscosity. Furthermore, we investigated the effect of tank-treading motion of RBCs on blood viscosity.
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