Predictor for supraphysiologic serum estradiol elevation on hCG triggering day of controlled ovarian stimulation using letrozole and gonadotropins in women with estrogen-dependent cancers

( Gwang Bin Lee ),( Soo Jin Han ),( Sung Woo Kim ),( Hoon Kim ),( Seung Yup Ku ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: The objective of study was to evaluate predicting factors for supraphysiologic serum estradiol(E2) elevation during controlled ovarian stimulation (COS) with administration of letrozole and gonadotropin in patients with estrogen-dependent cancer. Use of aromatase inhibitors is recommended to prevent the potential effect of elevated serum E2 level and recurrence of tumor in patients with estrogen-dependent cancers during COS. Although previous studies reported that letrozole have shown an effective lowering of peak E2 level, a part of patients shows supraphysiologic levels of E2 associated with ovarian stimulation despite the administration of letrozole. Methods: From January 2009 to December 2019, patients with estrogen-dependent cancer who underwent COS with antagonist protocol using a letrozole (5 mg/ day) to keep estrogen level low were included in this study. Early monitoring serum E2 was measured in all patients on the 4-6th day of stimulation. Subjects were classified into two groups according to the serum E2 level on hCG triggering day, physiologic E2 group (400 pg/mL) and supraphysiologic E2 group (>400 pg/mL). Results: A total of 96 COS cycles were retrospectively analyzed. Supraphysiologic level of serum E2 was found in 21.9% of the patients. Mean age, AMH, duration of stimulation, total dose of gonadotropins administered were not different between two groups. However, early monitoring serum E2 level was significantly higher in the supraphysiologic E2 group (67.1±47.9 vs. 115.6±78.1, p=0.001) and was associated with the occurrence of supraphysiologic elevation of serum E2 on hCG triggering day. Patients with early monitoring serum E2 ≥84.5 pg/mL had an odds ratio of 5.376 [95% CI, 1.613-17.913] for supraphysiologic elevation of serum E2 compared to those with early monitoring serum E2 below 84.5 pg/mL Conclusion: Early monitoring serum E2 is an independent predicting factor for supraphysiologic level of serum E2 on hCG triggering day in the COS cycle using letrozole and gonadotropin.

Plasma lipid profile comparison of five different cancers by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry

Lee, Gwang Bin,Lee, Jong Cheol,Moon, Myeong Hee Elsevier 2019 Analytica chimica acta Vol.1063 No.-

<P><B>Abstract</B></P> <P>A comprehensive lipidomic analysis at the molecular level using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was performed to elucidate the lipid profiles of patient blood samples from five commonly found cancers (liver, lung, gastric, colorectal, and thyroid), which were then compared with the lipid profiles of healthy controls. From a total of 335 lipids identified and quantified, 50 high abundance lipids showing significant changes (>2-fold and <I>p</I> < 0.01) in at least one of the five cancers (vs. controls) were analysed. Lipid species were found to be significantly associated with more than one type of cancer; the numbers of lipid species found as significantly changed in all five, four, three, two, and one type of cancer were 1, 8, 8, 15, and 17, respectively. Among these, the high abundance phosphatidylethanolamine species, including lysophosphatidylethanolamine and PE plasmalogen, was significantly low in four cancer types, but was high in thyroid cancer. Receiver operating characteristic analysis resulted in the selection of lipids specific to each cancer: liver (four phosphatidylinositols and diacylglycerol 16:1_18:0), gastric (phosphatidylcholine 34:2, 36:3, and 36:4, and lysophosphatidic acid 18:2), lung (lysophosphatidylinositol 16:0, sphingomyelin d18:1/20:0, and triacylglyceride 50:1 and 54:4), and thyroid (lysophosphatidylinositol 18:0 and 18:1). Our results provide a basis for future validation of cancer-specific lipid markers with high diagnostic ability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Plasma lipids from patients with five different cancers were compared by nUHPLC-MS/MS. </LI> <LI> PE, LPE, and PE plasmalogen were significantly decreased in all cancers, except thyroid cancer. </LI> <LI> Of 50 selected lipids (>2-fold change; <I>p</I> < 0.05), 33 were significantly changed in multiple cancers. </LI> <LI> Eighteen lipids were found to be unique to only one cancer type. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

수산·해운계열 사범학과 대학생이 인식하는 중등직업교육 교원의 직업기초능력에 관한 중요도-실행도 차이 분석(IPA)

이광빈(Gwang-Bin LEE),이미람(Mi-Ram LEE),박종운(Jong-Woon PARK) 한국수산해양교육학회 2024 水産海洋敎育硏究 Vol.36 No.3

The purpose of this study is to find out the basic vocational skills necessary for high school teachers in the fisheries and shipping sectors recognized by college students in the fisheries and shipping sectors. For this, IPA analysis was conducted and visualized. As a result of the study, among 11 areas, the basic vocational skills recognized as important by college students in the fisheries and shipping sectors as secondary vocational education teachers were the highest in self-development skills (M=4.18, SD=.74). On the other hand, the performance level currently being studied in the fisheries and shipping sectors was the highest in interpersonal skills (M=3.90, SD=.80). And the focus area was found to be the ability to use information (b). In addition, the low priority areas were found to be resource management ability (d), technology utilization ability (e), and change management ability (i). Based on this, policy proposals such as reducing the proportion of fixed-term teachers and entering graduate schools were made as a way to improve the basic vocational skills of college students in the Department of Education in the fisheries and shipping sectors.

수산·해운계열 특성화고등학교 입학생의 진로선택에 미치는 요인 연구

이광빈(Gwang-Bin LEE),문희성(Hee-sung MOON),김성(Sung KIM),박종운(Jong-Un PARK) 한국수산해양교육학회 2023 水産海洋敎育硏究 Vol.35 No.6

The purpose of this study is to find out the factors that influence the motivation of students in specialized high schools in the fisheries and Maritime sectors. The conclusion of this study is summarized as follows. First, students at specialized high schools in the fisheries and Maritime sectors tend to be self-directed in admission, and their parents have a great influence. Second, students of specialized high schools in the fisheries and Maritime sectors are thinking positively about the future of the fisheries and Maritime industries along with specialized high schools in the fisheries and shipping sectors. Third, students at specialized high schools in the fisheries and Maritime sectors differed in the factors affecting career choice depending on their location. Fourth, students at specialized high schools in the fisheries and Maritime sectors differed in the factors affecting career choice depending on the department. The policy suggestions based on the above research are as follows. First, specialized high schools in the fisheries and Maritime sectors should seek discriminatory ways to secure new students according to school and department. Second, efforts should be made to positive expectations for the fisheries and shipping sectors of students at specialized high schools in the fisheries and Maritime sectors.

특성화고등학교의 교육서비스품질과 전공만족도의 관계에서 진로결정자기효능감의 매개효과 연구: 성별 간 다집단분석

이광빈(Gwang-Bin LEE) 한국수산해양교육학회 2024 水産海洋敎育硏究 Vol.36 No.3

The purpose of this study is to find out the direct and indirect effects of educational service quality in specialized high schools on career decision-making self-efficacy through major satisfaction. In addition, group differences between genders were studied. To this end, the study was conducted with 474 students from specialized high schools. Education service quality not only has a direct effect on career decision-making self-efficacy, which is the dependent variable (B=.275), but also has an indirect effect on career decision-making self-efficacy by mediating major satisfaction (B=.408). As a result of the analysis of the mediating effect between the two groups, in the case of male students, there was no direct effect from educational service quality to career decision-making self-efficacy (B=.151), but there is an indirect effect through major satisfaction (B=.588). In the case of female students, there is a direct effect from educational service quality to career decision-making self-efficacy (B=.316), and there is an indirect effect through major satisfaction (B=.267). Based on these studies, policy suggestions and suggestions for subsequent research were presented.

부산지역 중학교 교사의 특성화고등학교 인식에 대한 현상학적 연구

이광빈(Gwang-Bin Lee),박종운(Jong-Woon Park),황미영(Mi-Young Hwang) 한국직업교육학회 2023 職業 敎育 硏究 Vol.42 No.1

본 연구의 목적은 부산지역 중학교 교사들이 인식하는 특성화고등학교의 인식을 연구하여, 여러 가지 어려운 상황에 있는 특성화고등학교에 미래 발전 방향과 빠르게 변화하고 있는 사회에서 미래지향적인 인재를 육성하고자 함에 보탬이 되고자 한다. 이에 본 연구에서는 부산지역 중학교 교사 7명을 대상으로 질적연구를 시행하였다. 본 연구에서는 인터뷰 참여 교사들의 일반적인 영역, 교사 시각에서의 특성화고등학교의 이미지, 교사가 바라보는 학생 시각에서의 특성화고등학교의 이미지, 특성화고등학교 진학 학생의 특성, 특성화고등학교 교육정책에 대한 의견, 전문가가 생각하는 특성화고등학교의 장점과 단점, 전문가가 생각하는 특성화고등학교에 필요한 개선점의 7가지 영역으로 인터뷰를 실시하였다. 인터뷰 내용을 전사하여 이를 네트워크 분석을 실시하였고, 빈도수와 중심성을 상위 단어를 바탕으로 주제별・하위요인별 분석을 실시하였다. 이를 통해 첫째, 특성화고등학교에 대한 인식개선이 필요성, 둘째, 기초학력 부족 학생을 위한 지원과 대책의 필요성을 제안하였다. The purpose of this study is to study the perception of specialized high schools recognized by middle school teachers in Busan and to help foster future-oriented talents in the direction of future development and rapidly changing society in various difficult situations. Therefore, in this study, a qualitative study was conducted on 7 middle school teachers in Busan. In this study, the interview was conducted in seven areas: general areas of interview participants, image of specialized high school from teacher's perspective, image of specialized high school from teacher's perspective, student's opinion, opinion on specialized high school education policy, and improvement needed for specialized high school. The interview contents were transcribed and network analysis was conducted, and the frequency and centrality were analyzed by subject and sub-factor based on the upper words. Through this, first, the necessity of improving awareness of specialized high schools, and second, the necessity of support and countermeasures for students with insufficient basic education was proposed.

키워드 네트워크 분석을 활용한 직업교육연구 학회지의 연구동향 분석

이광빈(Gwang-Bin Lee),황미영(Mi-Young Hwang),박종운(Jong-Un Park) 한국직업교육학회 2021 職業 敎育 硏究 Vol.40 No.1

이 연구의 목적은 직업교육연구 학회지에 게재된 논문들을 키워드 네트워크 분석법을 실시하여 국내의 직업교육훈련과 관련된 연구동향과 특성을 파악하여 직업교육이 나아가야 할 방향을 모색하고자 한다. 2008년부터 2020년까지의 게재 논문 577편을 대상으로 정부 시기별 주제어들의 빈도분석과 이들의 네트워크 구조를 분석하였다. 빈도분석에 있어서 연구결과는 자기효능감, 만족도, 특성화고등학교와 같은 단어들은 각 시기별 빈도수 상위 20위 내에 공통적으로 나오는 키워드로써 활발한 연구가 이루어지는 주제이다. 키워드 네트워크 분석결과는 이명박 정부 시기의 연결중심성은 자기효능감, 진로성숙도의 키워드가 높게 나타났으며, 매개중심성의 경우 자기효능감, 진로성숙도의 키워드가 높게 나타났다. 박근혜 정부 시기의 연결중심성은 자기효능감, 진로성숙도의 키워드가 높게 나타났으며, 매개중심성의 경우 자기효능감, 대학생의 키워드에서 높게 나타났다. 문재인 정부 시기의 연결중심성은 만족도, 자기효능감의 키워드가 높게 나타났으며, 매개중심성의 경우 직무만족, 만족도의 키워드에서 높게 나타났다. 본 연구결과를 바탕으로 향후 직업교육훈련의 발전방향과 시사점은 다음과 같다. 논문들에서 주제어의 양적 증가가 있었으며, 각 정부마다 주목받는 키워드가 나타났다. 하지만, 4차 산업혁명이나 코로나-19와 같은 최근 많은 관심을 보이고 있는 키워드의 빈약 혹은 부재는 향후 연구 직업교육연구가 탐구해야 할 과제라고 생각한다. 향후 빅데이터, AI, 비대면 수업, 블랜디드 러닝과 같은 새로운 분야에서 활발한 연구가 이루어졌으면 한다. The purpose of this study is to identify the research trends and characteristics related to domestic vocational education and training through a keyword network analysis method of papers published in the Journal of Vocational Education Research to find the direction in which vocational education should proceed. For the 577 publications published from 2008 to 2020, the frequency analysis of key words in the government period and their network structure were analyzed. In frequency analysis, words such as self-efficacy, satisfaction and specialized high schools are common keywords in the top 20 of each period. The results of keyword network analysis showed that the Degree centrality of the Lee Myung-bak administration was high in the keywords of self-efficacy and career maturity. In the case of Betweenness centrality, the keywords of self-efficacy and career maturity were high. In the Degree centrality of the Park Geun-hye administration, the keywords of self-efficacy and career maturity were high. In the case of Betweenness centrality, the keywords of self-efficacy and college student were high. As for the Degree centrality of the Moon Jae-in administration, the keywords of satisfaction and self-efficacy were high. In the case of Betweenness centrality, the keywords of job satisfaction and satisfaction were high. Based on the results of this study, the future direction and implications of vocational education and training are as follows. There was a quantitative increase in the number of key words in the papers, and keywords attracting attention were found in each government. However, I think that the lack or absence of keywords that have recently shown a lot of interest, such as the Fourth Industrial Revolution or Corona-19, is an issue that should be explored for future research and vocational education research. I hope that there will be active research in new fields such as big data, AI, non-face-to-face classes, and blended learning in the future.

A Rare Case of Signet Ring Cell Carcinoma Arising on Duodenal Brunner’s Gland Hyperplasia Successfully Treated Via Endoscopic Resection

Hae Rin Lee,Bong Eun Lee,Kyung Bin Kim,Gwang Ha Kim,Moon Won Lee,Dong Chan Joo 대한상부위장관ㆍ헬리코박터학회 2024 Korean Journal of Helicobacter Upper Gastrointesti Vol.24 No.2

Signet-ring cell carcinoma (SRCC) is a rare tumor that most commonly occurs in the stomach. Duodenal SRCCs are extremely uncommon and account for approximately 1% of duodenal adenocarcinomas. Although Brunner’s gland hyperplasia (BGH) is a benign duodenal condition, studies have reported several cases of adenocarcinoma originating in an area of BGH. We report a rare case of early-stage SRCC originating in an area of BGH that was successfully treated using endoscopic mucosal resection. Based on the mucin phenotype observed in this case, it is reasonable to conclude that SRCC originated from gastric metaplasia in the area of BGH. Although BGH is a benign condition, careful evaluation is warranted for early detection of combined neoplasms.

빅데이터 기반 가상화폐 공시 분석 AI 연구

정용빈 ( Yong-bin Jeong ),안상훈 ( Sang-hun An ),이세욱 ( Se-uk Lee ),박현성 ( Hyun-sung Park ),이도윤 ( Do-yun Lee ),이효경 ( Hyo-kyung Lee ),안정운 ( Jeong-wun An ),고진광 ( Jin-gwang Koh ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2

인터넷 가상화폐 거래소에 게시되는 공시를 분석하여 향후 게시된 공시가 가상화폐 가격에 줄 영향을 예측해보고자 한다. 과거 게시된 공시 데이터를 바탕으로 딥러닝을 이용해 영향치를 도출해낸다. 프로그램은 Python 언어로 작성하였으며, django 웹 프레임워크를 이용하여 결과치를 보여줄 수 있는 웹 사이트를 구현하였다. 또한 공시를 통합한 데이터를 이용하여 새로 게시되는 공시가 해당 가상화폐의 가격에 줄 예측치를 분석하였으며 해당 공시가 가상화폐의 가격에 어떻게 영향을 줄지 쉽게 판단할 수 없는 사용자들에게 도움을 줄 수 있을 것이다.

Gastric adenocarcinoma with enteroblastic differentiation in a 67-year-old man in Korea: a case report

Hae Rin Lee,Gwang Ha Kim,Dong Chan Joo,Moon Won Lee,Bong Eun Lee,Kyung Bin Kim Ewha Womans University School of Medicine 2024 EMJ (Ewha medical journal) Vol.47 No.2

We report a rare case of gastric adenocarcinoma with enteroblastic differentiation (GAED) that was treated with endoscopic submucosal dissection followed by additional distal gastrectomy with lymph node dissection. A 67-year-old man underwent endoscopic submucosal dissection for a gastric lesion, which was diagnosed as GAED with submucosal and lymphatic invasion. Histologically, GAED is characterized by a tubulopapillary growth pattern and clear cells that resemble those of the primitive fetal gut. Immunohistochemically, GAED variably expresses oncofetal proteins such as glypican-3, alpha-fetoprotein, and spalt-like transcription factor 4. Despite negative margins, additional gastrectomy with lymph node dissection was performed due to submucosal and lymphatic invasion. No residual tumor or metastasis was detected, and the patient remained disease-free for 2 years before dying from causes unrelated to GAED. Given its aggressive nature, frequent lymphovascular invasion, and high metastatic potential, clinicians should recognize the histopathological diagnosis of this rare tumor and its propensity for aggressiveness.