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- 저자 : Guoqing Fan (검색결과 5 건)
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Guoqing Fan,Yi Guo,Fujie Tang,Min Chen,Shuang Liao,Juan Wang 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.4
Background and Purpose Most of the knowledge of Mycoplasma pneumonia (M. pneumoniae) encephalitis (MPE) in children is based on case reports or small case series. This study aimed to describe the clinical features and prognostic factors of MPE, and the efficacy of azithromycin with or without immunomodulatory therapy. Methods The medical data of 87 patients with MPE from 3 medical centers in southwestern China over a 7-year period were reviewed. Results MPE was found in children of all ages except for neonates. The most common neurological manifestations included consciousness disturbance (90%) and headache (87.4%), the most common extraneurological manifestations included fever (96.5%) and respiratory system involvement (94.3%); multisystem involvement (98.2%) and elevated C-reactive protein (CRP) (90.8%) were also prominent. M. pneumoniae was detected in cerebrospinal fluid (CSF) less often than in blood and respiratory tract secretions. Azithromycin with intravenous immunoglobulin or/and corticosteroid treatment can shorten the hospitalization duration and the clinical improvement process. Most patients (82.8%) received a favorable prognosis; serum lactate dehydrogenase (LDH) and CSF protein levels were higher in the poor-outcome group than in the good-outcome group (p<0.05). Neurological sequelae are likely to continue when the onset of this condition occurs during teenage years. Conclusions MPE generally presented with nonspecific clinical manifestations. In children with acute encephalitis accompanied by multi-system involvement and prominently elevated CRP, M. pneumoniae should be considered as a possible pathogen. Immunomodulating therapies should be recommended regardless of the duration of the prodromal period. High CSF protein level, blood LDH elevation, and higher age may be associated with an unfavorable outcome.
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Numerical modeling of a self-propagating high-temperature synthesis process of the TiC system
Guoqing Xiao,Quncheng Fan,Gang Zhang 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.5
A self-propagating high-temperature synthesis process of the TiC reactive system was numerically simulated to investigate the effect of porosity and diluent on the SHS reaction and its activating mechanism by an implicit difference method (IDM) and a Gauss-Seidel iteration procedure. The new features of the model include a consideration of the melting of each constituent of the reactants and product and the inclusion of considerations involving dilution and porosity. The results show that as the porosity is varied, there is not a significant effect on the combustion temperature and mode of the combustion front, and the nature of the combustion front is steady and uniform because of the lower activation energy in this system. As the reactant porosity values are decreased, the combustion velocity first increases because of an increase in the thermal conductivity. The combustion velocity, after reaching a maximum, decreases with a further decrease in the porosity because of the high value of the thermal conductivity of the reactants. To study the effect of the diluent, the product itself is considered as the diluent. The effect of adding the diluent to the initial reactants is to decrease the combustion temperature and the combustion velocity. A self-propagating high-temperature synthesis process of the TiC reactive system was numerically simulated to investigate the effect of porosity and diluent on the SHS reaction and its activating mechanism by an implicit difference method (IDM) and a Gauss-Seidel iteration procedure. The new features of the model include a consideration of the melting of each constituent of the reactants and product and the inclusion of considerations involving dilution and porosity. The results show that as the porosity is varied, there is not a significant effect on the combustion temperature and mode of the combustion front, and the nature of the combustion front is steady and uniform because of the lower activation energy in this system. As the reactant porosity values are decreased, the combustion velocity first increases because of an increase in the thermal conductivity. The combustion velocity, after reaching a maximum, decreases with a further decrease in the porosity because of the high value of the thermal conductivity of the reactants. To study the effect of the diluent, the product itself is considered as the diluent. The effect of adding the diluent to the initial reactants is to decrease the combustion temperature and the combustion velocity.
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Chen, Guoqing,Li, Tianbin,Wang, Wei,Guo, Fan,Yin, Hongyu Techno-Press 2017 Geomechanics & engineering Vol.13 No.1
The failure mechanism of a deep hard rock tunnel under high geostress and high geothermalactivity is extremely complex. Uniaxial compression tests of granite at different temperatures were conducted. The complete stress-strain curves, mechanical parameters and macroscopic failure types of the rock were analyzed in detail. The brittleness index, which represents the possibility of a severe brittleness hazard, is proposed in this paperby comparing the peak stress and the expansion stress. The results show that the temperature range from 20 to $60^{\circ}C$ is able to aggravate the brittle failure of hard rock based on the brittleness index. The closure of internal micro cracks by thermal stress can improve the strength of hard rock and the storage capacity of elastic strain energy. The failure mode ofthe samples changes from shear failure to tensile failure as the temperature increases. In conclusion, the brittle failure mechanism of hard rock under the action of thermal coupling is revealed, and the analysis result offers significant guidance for deep buried tunnels at high temperatures and under high geostress.
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Ma Jian,Fan Xue,Sun Guoqing,Yin Fuquan,Zhou Guangxian,Zhao Zhihui,Gan Shangquan 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2
Objective: The aim of this research was to explore the effects of dietary substitution of alfalfa hay by amaranth hay on production performance, rumen fermentation, nutrient digestibility, serum biochemical parameters and antioxidant ability in dairy cows. Methods: A total of 45 healthy Holstein cows with same parity and similar milk yield and body weight were randomly divided into 3 groups: control diet without amaranth hay (CON) or 50% and 100% alfalfa hay replaced by an equal amount of amaranth hay (dry matter basis, AH1 and AH2, respectively). All the cows were fed regularly 3 times a day at 06:30, 14:30, and 22:30 and had free access to water. The experiment lasted for 60 d. Results: The dry matter intake of CON and AH1 groups was higher (p<0.05) than that of AH2 group. Compared with AH1 group, the milk yield of AH2 group was reduced (p<0.05). Moreover, dietary substitution of alfalfa hay by amaranth hay increased (p<0.05) milk fat, ammonia nitrogen and acetate concentrations. However, the crude protein digestibility of AH2 group was lower (p<0.05) than that of CON group, while an opposite tendency of serum urea nitrogen was found between two groups. The neutral detergent fiber digestibility of AH1 group was increased (p<0.05) when compared to AH2 group. Amaranth hay treatment increased (p<0.05) the serum concentration of glutathione peroxidase in dairy cows. Compared with CON group, the malonaldehyde activity of AH1 group was decreased (p<0.05). Conclusion: Dietary replacing alfalfa hay with amaranth hay (50% ratio) in dairy cows did not affect production performance but improved their antioxidant ability.
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