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- 저자 : Guojie Gao (검색결과 2 건)
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Serum metabolomics in mice after paraquat posioning
Lina Gao,Guang Wang,Huiya Yuan,Enyu Xu,Guojie Liu,Junting Liu 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Paraquat is toxic to humans and there is no antidote for paraquat poisoning. Moreover, the mechanisms of paraquat toxicity have not been clearly defined. Methods: In this study, we developed a serum metabolomic method using gas chromatography- mass spectrometry (GC-MS) to evaluate the effects of paraquat poisoning on mice. Pattern recognition analysis, including both principal component analysis and cross orthogonal partial least squares-discriminate analysis revealed that paraquat poisoning induced energy/redox cycle and metabolic perturbations. Results: Compared with the control group, the levels of creatinine, citric acid, succinic acid, fumaric acid and glycine in the sub acute paraquat poisoning group increased (P<0.05), while the levels of alpha-Tocopherol, 6-phosphogluconic acid and palmitoleic acid decreased (P<0.05). Conclusion: These findings provide an overview of systematic responses to paraquat exposure and metabolomic insight into the toxicological mechanism of paraquat. Our results demonstrate that the metabolomic method based on GC-MS can be a useful tool to elucidate the mechanism of PQ toxicity, and provide a new direction for its clinical diagnosis and treatment.
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Sai Zhang,Shijun Yue,Jiajia Li,Jian-Bin Zheng,Guojie Gao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11
Au nanoparticles anchored on core–shell α-Fe2O3@SnO2 nanospindles were successfully constructed through hydrothermal synthesis process and used for fabricating a novel nonenzymatic dopamine (DA) sensor. The structure and morphology of the Au/α-Fe2O3@SnO2 trilaminar nanohybrid film were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical properties of the sensor were investigated by cyclic voltammetry and amperometry. The experimental results suggest that the composites have excellent catalytic property toward DA with a wide linear range from 0.5 μM to 0.47 mM, a low detection limit of 0.17 μM (S/N = 3) and high sensitivity of 397.1 μA mM -1 cm -2. In addition, the sensor exhibits long-term stability, good reproducibility and anti-interference.
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