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- 저자 : Guo Xiaoxin (검색결과 4 건)
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Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells
Xiaoxin Li,Lizhong Guo,Fei Huang,Wei Xu,Guiqing Peng 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.6
Cornuside is a secoiridoid glucoside compound extracted from the fruits of Cornus officinalis. Cornuside has immunomodulatory and anti-inflammatory properties; however, its potential therapeutic effects on diabetic nephropathy (DN) have not been completely explored. In this study, we established an in vitro model of DN through treating mesangial cells (MMCs) with glucose. MMCs were then treated with different concentrations of cornuside (0, 5, 10, and 30 μM). Cell viability was determined using cell counting kit-8 and 5-ethynyl-2′-deoxyuridine assays. Levels of proinflammatory cytokines, including interleukin (IL)-6, tumor necrosis factor-α, and IL- 1β were examined using enzyme-linked immunosorbent assay. Reverse transcription quantitative real-time polymerase chain reaction and Western blotting were performed to detect the expression of AKT and nuclear factor-kappa B (NF-κB)-associated genes. We found that cornuside treatment significantly reduced glucose-induced increase in MMC viability and expression of pro-inflammatory cytokines. Moreover, cornuside inhibited glucose-induced phosphorylation of AKT and NF-κB inhibitor alpha, decreased the expression of proliferating cell nuclear antigen and cyclin D1, and increased the expression of p21. Our study indicates that the anti-inflammatory properties of cornuside in DN are due to AKT and NF-κB inactivation in MMCs.
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Harmonious Culture, Harmonious Enterprises and Harmonious Society
WANG Chunhe,GUO Xiaoxin 한국경영교육학회 2011 한국경영교육학회 학술발표대회논문집 Vol.2011 No.6
“Harmonious culture” is the core of Chinese culture and philosophy. The pursuit of the harmony between heaven and the humans, among the humans, between the body and the soul is the fundamental of the Chinese nation, while the idea of “harmony being the supreme” is the highest creed of Chinese civilization.In view of Chinese culture, the essence of harmonious culture lies in the balance or the equilibrium among the opposed things and of its unity and development. Accordingly, it is not only regarded as the principles society follows, but also the ultimate aim of social development.“Harmonious culture” has a profound influence and practical value on the constructing of harmonious enterprises and harmonious society.Harmonious society needs the strong material support of harmonious enterprises development. In return, harmonious society promotes enterprises development in harmony, both of which are complementary to each other.Constructing harmonious enterprises is not only the requirement of building harmonious society, but also the requirement of enterprises sustaining healthy development. An important symbol of enterprises being mature is the constructing of harmonious enterprises.
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Zipeng Gong,Ying Chen,Ruijie Zhang,Qing Yang,Yajie Wang,Yan Guo,Bingbing Zhou,Xiaogang Weng,Xuchen Liu,Yujie Li,Xiaoxin Zhu,Yu Dong 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
Berberine is one of active alkaloids from Rhizomacoptidis in traditional Chinese medicine. The pharmacokineticsof berberine in rat plasma were compared betweennormal and chronic visceral hypersensitivity irritable bowelsyndrome rats (CVH-IBS) established by mechanical colonirritation using angioplasty balloons for 2 weeks after oraladministration of berberine hydrochloride (25 mg/kg) withthe equivalent dose of 22 mg/kg for berberine according tobody weight. Immunohistochemical analysis of c-fos andmyosin light chain kinase (MLCK) and immunofluorescenceanalysis of MLCK in rat colon were conducted. Quantificationof berberine in rat plasma was achieved by using a sensitiveand rapidUPLC-MS/MSmethod. Plasma samples werecollected at 15 different points in time and the pharmacokineticparameters were analyzed by WinNonlin software. Thegreat different pharmacokinetic behavior of berberine wasobserved between normal and CVH-IBS model rats. Compared with normal group, T1/2 and AUC(0–t) of berberinein the model group were significantly increased, respectively(573.21 ± 127.53 vs 948.22 ± 388.57 min; 8,657.19 ±1,562.54 vs 11,415.12 ± 1,670.72 min.ng/ml). Cl/F of berberinein the model group significantly decreased, respectively(13.89 ± 1.69 vs 9.19 ± 2.91 L/h/kg). Additionally,the expressions of c-fos and MLCK in model group werehigher than those in normal group. The pharmacokinetic behaviorof berberine was significantly altered in CVH-IBSpathological conditions, which indicated the dosage modificationof berberine hydrochloride in CVH-IBS were necessary. Especially, improved exposure to berberine in ratplasma inCVH-IBSmodel rats was attributed to increased theexpression of MLCK.
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