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- 저자 : Guo Qingdong (검색결과 2 건)
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Comparative study on two finite element models for multi-clamp pipeline system
Yiming Cao,Qingdong Chai,Xumin Guo,Hui Ma,Pengfei Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3
Due to the limitations of space and environment, a considerable number pipelines supported by multiple clamps are used in the external pipeline system of aero engines, which lead to the modeling difficulties and low efficiency. In this paper, taking U-shaped and Zshaped pipelines as examples, two methods of whole modeling and section modeling are used based on the finite element, and the piecewise linear models of clamps are introduced to compare the vibration characteristics under different boundary conditions. In addition, the simulation results are compared and verified by experiments. In the modal analysis, the coupled modes refer to the dependent modes which can influence each other through energy transfer while independent modes without energy transfer are called un-coupled modes. The results show that, for uncoupled modes of U-shaped and Z-shaped pipeline systems, the section model has smaller error and higher efficiency, which is suitable for the primary design stage of complex multi-clamp pipeline system. For the order of coupled mode, the accuracy of the whole model is high, and it is suitable for the check and vibration analysis of pipeline system. Moreover, the errors of both models decrease with the increase of tightening torque.
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Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.
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