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      저자 : Guo Baoqiang (검색결과 2 건)
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      • KCI등재

        Finite element model updating of jointed structure based on modal and strain frequency response function

        Zhan Ming,Guo Qintao,Yue Lin,Zhang Baoqiang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10

        To acquire a reasonable model for structural dynamic strength analysis, a bottom-up finite element modeling and updating methodology based on multi responses is proposed. The fundamental principles of structural dynamics analysis and model updating were introduced, and the proposed strategy was applied to the case study of an L-shaped jointed structure. Components of the jointed structure were modeled sequentially, and inaccurate model parameters were updated based on the corresponding experimental modal results in the first stage. In the second stage, components were connected together by bolts. The joint interfaces were represented by thin-layer elements, and local joint parameters were updated based on strain frequency response function (FRF). Finally, the precision of finite element model (FEM) was validated by acceleration frequency response function. The results indicated that the proposed methodology is able to reduce model simulation errors in both components and the overall jointed structure. Not only can the updated model of a jointed structure reproduce the experimental results used in updating, but also predict responses that are not used in the process of model updating.

      • KCI등재

        Using Pre-Clinical Studies to Explore the Potential Clinical Uses of Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem cells

        Zhou Andrew Kailin,Jou Eric,Lu Victor,Zhang James,Chabra Shirom,Abishek Joshua,Wong Ethan,Zeng Xianwei,Guo Baoqiang 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.6

        Recent studies of exosomes derived from mesenchymal stem cells (MSCs) have indicated high potential clinical applications in many diseases. However, the limited source of MSCs impedes their clinical research and application. Most recently, induced pluripotent stem cells (iPSCs) have become a promising source of MSCs. Exosome therapy based on iPSC-derived MSCs (iMSCs) is a novel technique with much of its therapeutic potential untapped. Compared to MSCs, iMSCs have proved superior in cell proliferation, immunomodulation, generation of exosomes capable of controlling the microenvironment, and bioactive paracrine factor secretion, while also theoretically eliminating the dependence on immunosuppression drugs. The therapeutic effects of iMSC-derived exosomes are explored in many diseases and are best studied in wound healing, cardiovascular disease, and musculoskeletal pathology. It is pertinent clinicians have a strong understanding of stem cell therapy and the latest advances that will eventually translate into clinical practice. In this review, we discuss the various applications of exosomes derived from iMSCs in clinical medicine.

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