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적출한 흰쥐 대동맥에 있어서 postsynaptic alpha1-, alpha2- 아드레날린 수용체에 관한 연구
임광진(Guang Jin Im),조윤성(Yun Sung Cho),고광호(Kwang Ho Ko),김미영(Mie Young Kim) 대한약학회 1986 약학회지 Vol.30 No.3
alpha-Adrenoceptor subtypes in the isolated rat aortic strips were examined by using agonists and antagonists which have varying selectivity for alpha1- and alpha2-adrenoceptors. Norepinephrine and phenylephrine produced a similar magnitude of maximum contractions. pA2 values for prazosin and yohimbine were not significantly different using norepinephrine or phenylephrine as the agonist, suggesting a single population of alpha-adrenoceptor. Contractile responses produced by alpha-agonists were antagonized more effectively by prazosin (approximately 1000 fold) than by yohimbine.
Endosomal pH-destabilized PGA-PCL block copolymer micelle
김민상,카살라,Guang Jin Im,김봉섭,Doo Sung Lee 한국생체재료학회 2009 생체재료학회지 Vol.13 No.3
Poly(L-glutamic acid)-poly(ε-caprolactone) diblock copolymers were prepared using ring opening polymerization. The diblock copolymers were characterized by 1H-NMR, gel permeation chromatography and FT-IR. Endosomal pH-destabilized nanoparticles were prepared from dialysis method and their micellar structure was confirmed by dynamic light scattering and transmission electron microscopy. In this study, the method of fabrication and pHdependent structural changes of the diblock copolymer were investigated. pH-Dependent changeable nanoparticles may be helpful for intracellular delivery in drug delivery systems.
Kim, Dae-Kee,Lee, Ju Young,Kim, Jae-Sun,Ryu, Je-Ho,Choi, Jin-Young,Lee, Jun Won,Im, Guang-Jin,Kim, Tae-Kon,Seo, Jung Woo,Park, Hyun-Ju,Yoo, Jakyung,Park, Jung-Hyun,Kim, Tae-You,Bang, Yung-Jue 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b.
생약복합제 SKI306X 의 랫드에 대한 4 주 경구 반복투여 독성연구
김훈택(Hun Taek Kim),안재석(Jae Suk Ahn),정인호(In Ho Jeong),김택수(Taek Soo Kim),류근호(Keun Ho Ryu),임광진(Guang Jin Im),조용백(Yong Baik Cho),김대기(Dae Kee Kim),김환수(Hwan Su Kim),박광식(Kwang Sik Park),김기협(Key H . Kim),박병욱(P 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.1
This study was performed to determine the subacute toxicities of SKI306X, an antiinflammatory herbal extract, in rats. SKI306X was administered orally to rats once a day for 4 weeks at doses of 0.3, 1.0, and 3.0 g/㎏/ day. Each group consisted of 20 male and 20 female rats, including 5 male and 5 female rats per group for an interim study at the end of 2-week administration and for a 2-week recovery study, respectively. Throughout the study, all rats survived and no adverse clinical signs were observed. Although male rats treated with high dose (3.0 g/㎏/day) of SKI306X showed slight loss of body weight (approximately 5%) in comparison with control animals during the administration period, their body weight loss was normally restored during the recovery period. No significant change was found in all hematological parameters of SKI306X-treated groups except for the decreased number of red blood cells in all female groups at the interim study. Statistically significant changes were observed in several blood enzyme levels of SKI306X-treated groups; however, most of these significant changes were within normal range and statistically significant values did not show dose-related responses. In SKI306X-treated groups, the absolute and relative weights of liver, heart, and stomach were statistically different from those of control group, but these differences disappeared at the end of recovery period and also drug-related gross and histopathological findings in these organs were not found. No other drug-related gross and histopathological findings were observed. It is concluded from the results of this study that non-toxic dose of SKI306X was estimated to be between 0.3 and 1.0 g/㎏/day and the maximum tolerated dose of SKI306X was assumed to be higher than 3.0 g/㎏/day.
류근호,한창균,이해인,김택수,정인호,이성재,임광진,이강진,정기원,김대기,김기협,조용백,Ryu, Keun-Ho,Han, Chang-Kyun,Rhee, Hae-In,Kim, Taek-Soo,Jung, In-Ho,Lee, Sung-Jae,Im, Guang-Jin,Lee, Kang-Jin,Jeong, Ki-Won,Kim, Dae-Kee,Kim, Key-H.,Cho 한국생약학회 1999 생약학회지 Vol.30 No.4
The anti-asthmatic activities of the extract of Lonicera japonica (BuOH fraction) and its mode of action were investigated using several in vitro and in vivo models. Lonicera japonica was extracted with 30% ethanol (v/v) and successively partitioned into BuOH. The BuOH fraction reduced antigen-induced contraction of isolated trachea from sensitized guinea pigs in a concentration-dependent manner. The BuOH fraction also inhibited histamine release from rat peritoneal mast cells induced by antigen or calcium ionophore A23187 ($IC_{50}=0.26$ and 0.32mg/ml, respectively). Eosinophil infiltration into bronchoalveolar lavage fluids induced by aeroallergen challenge in passively sensitized guinea pigs was inhibited by the BuOH fraction at a dose of 800mg/kg (51.7%). In addition, the BuOH fraction inhibited leukotriene $B_4$ prodution in rat basophilic leukemia cells ($IC_{50}=0.42\;mg/ml$) as well as phosphodiesterase 4 (PDE4) isolated from rat brain ($IC_{50}=0.015\;mg/ml$). All results from this study strongly suggest that the BuOH fraction of Lonicera japonica may be useful in the treatment of asthma and its mode of action may be related with inhibition of both 5-lipoxygenase and PDE4 enzyme.