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Association between Alcohol Consumption and Survival in Colorectal Cancer: A Meta-analysis
Kim, Youngyo,Je, Youjin,Giovannucci, Edward L. American Association for Cancer Research 2019 Cancer Epidemiology, Biomarkers & Prevention Vol.28 No.11
<P><B>Background:</B></P><P>Although an association between alcohol consumption and risk of colorectal cancer is well established, little is known about the association between alcohol consumption and colorectal cancer survival. We conducted a meta-analysis of prospective cohort studies to quantitatively assess this association.</P><P><B>Methods:</B></P><P>Data searches were performed using PubMed and ISI Web of Science databases through December 2018. We estimated pooled RRs with 95% confidence intervals (CI) using random-effects models.</P><P><B>Results:</B></P><P>Twelve studies with 32,846 patients with colorectal cancer were included in the meta-analysis. Compared with no alcohol consumption, light (RR = 0.87; 95% CI, 0.81–0.94) and moderate (RR = 0.92; 95% CI, 0.85–1.00) prediagnostic alcohol consumption were associated with lower risk of all-cause mortality. Light prediagnostic alcohol consumption was associated with lower risk of colorectal cancer–specific mortality (RR = 0.87; 95% CI, 0.78–0.98). However, heavy prediagnostic alcohol consumption was not significantly associated with colorectal cancer survival. In a dose–response analysis, a nonlinear association between prediagnostic alcohol consumption and all-cause mortality was observed (<I>P</I><SUB>nonlinearity</SUB> = 0.0025), showing the reduction in RR at <30 g/day of alcohol consumption. By type of alcohol, wine consumption was associated with lower risk of mortality from all-causes and colorectal cancer, but a positive association was observed between moderate liquor consumption and all-cause mortality. There was no association between postdiagnostic alcohol consumption and colorectal cancer survival.</P><P><B>Conclusions:</B></P><P>Light and moderate prediagnostic alcohol consumption were associated with better survival in colorectal cancer.</P><P><B>Impact:</B></P><P>Our findings suggest that light and moderate alcohol consumption may be associated with better survival in colorectal cancer, but further studies are warranted.</P>
Long-term alcohol intake and risk of endometrial cancer in the Nurses' Health Study, 1980–2010
Je, Y,DeVivo, I,Giovannucci, E Nature Publishing Group 2014 The British journal of cancer Vol.111 No.1
<P><B>Background:</B></P><P>Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only.</P><P><B>Methods:</B></P><P>We prospectively examined the association between alcohol intake and endometrial cancer risk in the Nurses' Health Study with 68 067 female participants aged 34–59 years in 1980. Alcohol intake was measured several times with validated dietary questionnaires. We calculated cumulative average alcohol intake to represent long-term intakes of individual subjects. Using Cox proportional hazards models, we estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) for endometrial cancer risk after controlling for several risk factors simultaneously.</P><P><B>Results:</B></P><P>We identified a total of 794 invasive endometrial adenocarcinoma from 1980 to 2010. We found an inverse association among alcohol drinkers (multivariable RR=0.81; 95% CI: 0.68–0.96) compared with nondrinkers. Women with light alcohol intake of <5 g per day (∼half drink per day) had a 22% lower risk of endometrial cancer (multivariable RR=0.78; 95% CI: 0.66–0.94). Higher intake of alcohol, however, did not provide additional benefits against endometrial cancer: multivariable RRs for 5–14.9 g (∼1 drink), 15–29.9 g (∼2 drinks), or ⩾30 g (⩾2 drinks) versus 0 g per day were 0.88, 0.83, and 0.78 (95% CI: 0.49–1.25), respectively. The lower risk among drinkers (∼half drink per day) appeared to be stronger for obese women, but no significant interaction by body mass index was found.</P><P><B>Conclusions:</B></P><P>This study provides prospective evidence for an inverse association between light alcohol intake (∼half drink per day) in the long term and endometrial cancer risk, but above that level no significant association was found.</P>
Resting heart rate as a prognostic factor for mortality in patients with breast cancer
Lee, D. H.,Park, S.,Lim, S. M.,Lee, M. K.,Giovannucci, E. L.,Kim, J. H.,Kim, S. I.,Jeon, J. Y. Springer Science + Business Media 2016 Breast cancer research and treatment Vol.159 No.2
<P>Although elevated resting heart rate (RHR) has been shown to be associated with mortality in the general population and patients with certain diseases, no study has examined this association in patients with breast cancer. A total of 4786 patients with stage I-III breast cancer were retrospectively selected from the Severance hospital breast cancer registry in Seoul, Korea. RHR was measured at baseline and the mean follow-up time for all patients was 5.0 +/- 2.5 years. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression models. After adjustment for prognostic factors, patients in the highest quintile of RHR (aeyen85 beat per minute (bpm)) had a significantly higher risk of all-cause mortality (HR: 1.57; 95 %CI 1.05-2.35), breast cancer-specific mortality (HR: 1.69; 95 %CI 1.07-2.68), and cancer recurrence (HR: 1.49; 95 %CI 0.99-2.25), compared to those in the lowest quintile (aecurrency sign67 bpm). Moreover, every 10 bpm increase in RHR was associated with 15, 22, and 6 % increased risk of all-cause mortality, breast cancer-specific mortality, and cancer recurrence, respectively. However, the association between RHR and cancer recurrence was not statistically significant (p = 0.26). Elevated RHR was associated with an increased risk of mortality in patients with breast cancer. The findings from this study suggest that RHR may be used as a prognostic factor for patients with breast cancer in clinical settings.</P>