http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ging-Yuek Robin Hsiung (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
윤영철,Ging-Yuek Robin Hsiung 대한치매학회 2015 Dementia and Neurocognitive Disorders Vol.14 No.4
Background and Purpose One of the most common genetic causes of frontotemporal dementia (FTD) is mutation in the progranulin(PGRN) gene. The aim of this study is to assess the early effects of the PGRN mutations on brain volumes by longitudinal voxel based morphometric(VBM) evaluation in asymptomatic mutation carriers. Methods We recruited 17 asymptomatic members of families with FTD caused by PGRN mutations; 7 mutation carriers (51.0±11.6 yr)and 10 non-carriers (55.2±6.0 yr, p=0.404). The MRI follow-up intervals of carriers and non-carriers were 788.6±103.8 and 922.0±225.1 days(p=0.124) respectively. We performed cross-sectional and longitudinal VBM analysis on both groups. Results At baseline, the carriers had lower white matter (WM) volumes in left frontal regions (p<0.001, uncorrected), but had no gray matter(GM) volume reduction. The carrier’s global GM (p=0.924) and WM volume (p=0.364) reduction rate were not different from the noncarrier’s. However, statistical parametric mapping T-maps showed differentially increased GM volume reductions in the bilateral parietal areasof carriers (p<0.001, uncorrected). Conclusions The findings from this study to examine WM and GM cross-sectional and longitudinal changes in PGRN mutation carrierssuggest that WM atrophic changes could precede both GM changes and symptom onset in FTD. Asymptomatic PGRN mutation carriershave measurably higher rates of regional GM atrophy than non-carriers even in the pre-dementia stages.
-
윤영철,김상윤,권오상,박태환,기백석,하삼열,Ging-Yuek Robin Hsiung 대한치매학회 2011 Dementia and Neurocognitive Disorders Vol.10 No.3
Background: Understanding the changes of brain volume due to normal aging in healthy adults may help us better appreciate the age-related changes in the brain associated with neurodegenerative diseases. The objectives of our current study are: 1) to evaluate the volumes of gray matter, white matter and cerebrospinal fluid in healthy adult with exclusion of white matter hyperintensity and 2) to identify their regional changes in which there have been controversies. Methods: We performed a cross-sectional analysis of magnetic resonance images from 108 normal Korean subjects (42-80 yr of age) using voxel-based morphometry. Results: Global volumes of each tissue revealed no change between 5th and 6th decade and their declines afterward. There were negative correlations between gray matter (3.04 cm3/yr) and white matter volume (2.31 cm3/yr) and increasing age, and a positive correlation between CSF volume (5.56 cm3/yr) and increasing age. Gray matter, white matter and CSF volume normalized with total intracranial volume demonstrated changes at 0.21%/yr, 0.16%/yr and 0.36%/yr respectively. Gray matter volume was reduced in the frontal, parietal and temporal lobes with increasing age, but not in the medial temporal lobes or posterior cingulate. White matter losses occurred in the anterior corpus callosum, frontal and other periventricular areas. Conclusions: These findings provide essential information on the rates and regional patterns of age-related changes in brain volume for a healthy Asian population, which can serve as a baseline for comparison with other pathologic conditions.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
