http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Gianni Mistrello (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
IgE Cross-Reactivity between Humulus japonicus and Humulus lupulus
정경용,이종선,Gianni Mistrello,박경희,박중원 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.7
Purpose: Japanese hop (Humulus japonicus) is a major cause of weed pollinosis in East Asia. However, supplies of commercialallergen extract from this plant have not met clinical demand. The pollen of common hop (Humulus lupulus), a closely relatedspecies, may provide an alternative source if there is strong IgE cross-reactivity between these two species. We aimed to comparethe IgE cross-reactivity and allergenicity of common hop and Japanese hop pollen. Materials and Methods: Cross-reactivity was measured by inhibition ELISA. One- and two-dimensional (2D) gel analyses combinedwith IgE immunoblotting and mass spectrometry [liquid chromatography coupled to electrospray ionization tandem massspectrometry (LC-ESI-MS/MS)] were performed to detect IgE-reactive pollen components. Results: Up to 16.7% of IgE reactivity to Japanese hop was inhibited by common hop. A 12-kDa protein component of Japanese hoppollen that showed the most potent IgE reaction was absent from common hop. Six IgE-reactive components from Japanese hopwere detected by 2D gel electrophoresis and LC-ESI-MS/MS, but showed low Mascot scores, preventing positive identification. Conclusion: No significant IgE cross-reaction was observed for Japanese and common hop pollen allergens. Development of allergydiagnostic and immunotherapeutic reagents based on Japanese hop pollen are urgently needed.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
